INT121302

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.91
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1)
extracellular space (Tgfb1) extracellular region (Tgfb1) cell death (Tgfb1)
Anatomy Link Frequency
apoptotic cells 2
Tgfb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 100.00 Very High Very High Very High
Inflammation 10 99.64 Very High Very High Very High
Arthritis 4 90.64 High High
metalloproteinase 31 84.00 Quite High
cytokine 15 52.68 Quite High
palliative 4 50.00 Quite Low
rheumatoid arthritis 7 35.44 Quite Low
Osteoarthritis 4 33.12 Quite Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 100.00 Very High Very High Very High
Apoptosis 24 99.20 Very High Very High Very High
Arthritis 4 90.64 High High
Rheumatic Diseases 4 88.80 High High
Disease 1 77.64 Quite High
Autoimmune Disease 1 74.20 Quite High
Pathologic Processes 2 73.28 Quite High
Cancer 1 68.48 Quite High
Reprotox - General 1 4 61.40 Quite High
Prostate Cancer 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During this period, additional irradiation fails to induce XRCC1, ERCC1, or additional TGF alpha release.


Positive_regulation (induce) of Localization (release) of TGF
1) Confidence 0.07 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0 Pain Relevance 0
Irradiation of DU145 xenografts also results in the activation of ERK1/2, release of TGF alpha, and a similar refractory period.
Positive_regulation (results) of Localization (release) of TGF
2) Confidence 0.07 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.06 Pain Relevance 0
Ionizing irradiation also results in the release of TGF alpha for patients undergoing radiation therapy for hormone-refractory prostate cancer.
Positive_regulation (results) of Localization (release) of TGF
3) Confidence 0.07 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.06 Pain Relevance 0
Irradiation of DU145 xenografts also results in the activation of ERK1/2, release of TGF alpha, and a similar refractory period.
Positive_regulation (activation) of Localization (release) of TGF
4) Confidence 0.07 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.06 Pain Relevance 0
The ingestion of apoptotic cells by inflammatory macrophages also promotes the synthesis and release of anti-inflammatory mediators such as TGF-b1 and IL-10 [14-16].
Positive_regulation (promotes) of Localization (release) of TGF-b1 in apoptotic cells associated with inflammatory mediators, inflammation and apoptosis
5) Confidence 0.01 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2988746 Disease Relevance 1.73 Pain Relevance 0.67

General Comments

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