INT121304

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 2.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xrcc1) intracellular (Xrcc1)
Anatomy Link Frequency
neuronal 1
SH-SY5Y 1
Xrcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 2 50.00 Quite Low
bDMF 10 46.24 Quite Low
anesthesia 10 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 40 99.18 Very High Very High Very High
Rheumatoid Arthritis 110 98.26 Very High Very High Very High
Infection 40 97.64 Very High Very High Very High
Reprotox - General 1 41 94.16 High High
Targeted Disruption 12 92.96 High High
Stress 179 91.60 High High
Hypoxia 3 84.76 Quite High
Hypersensitivity 30 79.56 Quite High
Apoptosis 185 71.68 Quite High
Adhesions 2 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infected cells were selected on the basis of puromycin resistance and expression of XRCC1 was analyzed regularly.
Gene_expression (expression) of XRCC1
1) Confidence 0.77 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.27 Pain Relevance 0
We point out that the nondividing XKD cells were down-regulated significantly for XRCC1 protein expression and exhibited ?
Gene_expression (expression) of XRCC1
2) Confidence 0.77 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.28 Pain Relevance 0
Stable suppression of the XRCC1 protein was achieved using the targeting shRNA system, while the scramble-shRNA infected cells retained XRCC1 expression.
Gene_expression (expression) of XRCC1
3) Confidence 0.77 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.16 Pain Relevance 0
Finally, we note that Narciso et al. (33) recently reported down-regulation of XRCC1 in differentiated human skeletal muscle cells; however, analysis of expressional changes of several DNA damage response genes following RA-BDNF differentiation of SH-SY5Y neuroblastoma cells did not reveal down-regulation of XRCC1 protein expression (Kulkarni and Wilson, unpublished observations), suggesting a cell type-specific regulation of this gene product.
Gene_expression (expression) of XRCC1 in SH-SY5Y associated with neuroblastoma and rheumatoid arthritis
4) Confidence 0.77 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.41 Pain Relevance 0
Figure 1B shows the expression of XRCC1 protein in the control (scramble) and XRCC1-knockdown (XKD) shRNA replicating cells.
Gene_expression (expression) of XRCC1
5) Confidence 0.77 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.15 Pain Relevance 0
Resistant colonies were periodically checked for XRCC1 expression using standard western blotting procedures.
Gene_expression (expression) of XRCC1
6) Confidence 0.77 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.05 Pain Relevance 0
Irradiation during this refractory period does not increase the expression of XRCC1 or ERCC1.
Gene_expression (expression) of XRCC1
7) Confidence 0.70 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.07 Pain Relevance 0
Expression of phospho-extracellular signal-regulated kinase (ERK)1/2 and phospho-epidermal growth factor receptor (EGFR) and the DNA repair proteins XRCC1 and ERCC1 were determined by Western analyses.
Gene_expression (Expression) of XRCC1
8) Confidence 0.70 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.09 Pain Relevance 0
Figure 1B shows the expression of XRCC1 protein in the control (scramble) and XRCC1-knockdown (XKD) shRNA replicating cells.
Gene_expression (expression) of XRCC1
9) Confidence 0.67 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.16 Pain Relevance 0
Denoted is the position of XRCC1 protein and the Lamin AC loading control.
Gene_expression (position) of XRCC1
10) Confidence 0.67 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.39 Pain Relevance 0
Effect of XRCC1 deficiency on primary mouse and human neuronal cell survival
Gene_expression (deficiency) of XRCC1 in neuronal
11) Confidence 0.67 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.44 Pain Relevance 0
Shown is a representative western blot of XRCC1 protein expression in dividing XKD and control cells. ?
Gene_expression (expression) of XRCC1
12) Confidence 0.60 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.25 Pain Relevance 0
Radiation exposed DU145 cells had increased production of DNA repair proteins, XRCC1 and ERCC1 by ERK related mechanisms [42].
Gene_expression (production) of XRCC1
13) Confidence 0.25 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.22 Pain Relevance 0

General Comments

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