INT121307

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 12.69
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ercc1) chromosome organization (Ercc1) nucleus (Ercc1)
cytoplasm (Ercc1)
Anatomy Link Frequency
biliary tract 3
Ercc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 132 99.20 Very High Very High Very High
palliative 24 94.96 High High
Kinase C 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Cancer 220 99.62 Very High Very High Very High
Cancer 569 99.52 Very High Very High Very High
Bile Duct Neoplasms 121 99.46 Very High Very High Very High
Recurrence 297 99.38 Very High Very High Very High
Klatskin's Tumor 308 99.08 Very High Very High Very High
Gallbladder Neoplasms 66 98.60 Very High Very High Very High
Adenocarcinoma 13 94.80 High High
Reprotox - General 1 41 94.16 High High
Metastasis 72 92.88 High High
Disease 79 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, ERCC1 expression was mostly negative in 74 cases (65.5%).
Gene_expression (expression) of ERCC1
1) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.98 Pain Relevance 0
Additionally, we examined the expression of TP and ERCC1 associated with the response to 5-FU and cisplatin chemotherapy [15].
Spec (examined) Gene_expression (expression) of ERCC1
2) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.29 Pain Relevance 0
Expression of phospho-extracellular signal-regulated kinase (ERK)1/2 and phospho-epidermal growth factor receptor (EGFR) and the DNA repair proteins XRCC1 and ERCC1 were determined by Western analyses.
Gene_expression (Expression) of ERCC1
3) Confidence 0.69 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.09 Pain Relevance 0
Irradiation during this refractory period does not increase the expression of XRCC1 or ERCC1.
Gene_expression (expression) of ERCC1
4) Confidence 0.69 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.07 Pain Relevance 0
No significant differences were found in the expression of p53, cyclin D1, survivin, and ERCC1 between GB cancer and BDC.
Gene_expression (expression) of ERCC1 associated with klatskin's tumor and cancer
5) Confidence 0.63 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.26 Pain Relevance 0
Overexpression of the excision repair cross-complementation group 1 (ERCC1) gene, which is crucial in the repair of cisplatin-induced DNA adducts, has been reported to negatively influence to effectiveness of cisplatin-based chemotherapy [4].
Gene_expression (Overexpression) of ERCC1
6) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.89 Pain Relevance 0.21
The expression of p53, cyclin D1, survivin, TP, and ERCC1 did not independently predict poor outcome in univariate analysis.
Gene_expression (expression) of ERCC1
7) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.64 Pain Relevance 0
This study aims to compare the clinico-pathological characteristics and prognostic factors of GB and bile duct cancers, and also investigate the expression and clinical significance of TP and ERCC1, including several cell-cycle regulatory proteins in biliary tract cancers.


Spec (investigate) Gene_expression (expression) of ERCC1 in biliary tract associated with bile and biliary cancer
8) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.96 Pain Relevance 0.25
Among the 66 patients who received adjuvant treatment, there was no significant difference in TTR and OS associated with TP and ERCC1 expression (p = 0.212, 0.322 for TP; p = 0.591, 0.794 for ERCC1).


Gene_expression (expression) of ERCC1 associated with recurrence
9) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.45 Pain Relevance 0
The immunohistochemical staining patterns of p53, cyclin D1, survivin, thymidine phosphorylase, and ERCC1 showed no prognostic significance in biliary tract cancers.


Gene_expression (patterns) of ERCC1 in biliary tract associated with biliary cancer
10) Confidence 0.56 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 1.25 Pain Relevance 0.26
The goal of this study was to investigate anatomical site-related similarities and differences in biliary tract cancers and to assess the expression and clinical significance of functional proteins such as p53, cyclin D1, survivin, thymidine phosphorylase, and ERCC1.


Gene_expression (expression) of ERCC1 in biliary tract associated with biliary cancer
11) Confidence 0.56 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 0.71 Pain Relevance 0.19
The level of protein expression of p53, cyclin D1, survivin, thymidine phosphorylase, and ERCC1 was assessed by immunohistochemistry.


Gene_expression (expression) of ERCC1
12) Confidence 0.56 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 0.95 Pain Relevance 0.25
Overexpression of the excision repair cross-complementation group 1 (ERCC1) gene, which is crucial in the repair of cisplatin-induced DNA adducts, has been reported to negatively influence to effectiveness of cisplatin-based chemotherapy [4].
Gene_expression (Overexpression) of cross-complementation group 1
13) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.89 Pain Relevance 0.21
Radiation exposed DU145 cells had increased production of DNA repair proteins, XRCC1 and ERCC1 by ERK related mechanisms [42].
Gene_expression (production) of ERCC1
14) Confidence 0.24 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.27 Pain Relevance 0

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