INT121308

Context Info Confidence 0.50 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 0.60 Pain Relevance 0

nucleus (Xrcc1) intracellular (Xrcc1)

Xrcc1 (Mus musculus)

Pain Link Frequency Relevance Heat palliative 1 50.00 Kinase C 5 5.00 cytokine 2 5.00 bDMF 2 5.00 anesthesia 2 5.00 adenocard 2 5.00 cINOD 1 5.00 Taxol 1 5.00

Disease Link Frequency Relevance Heat Infection 8 98.04 Hypoxia 3 85.16 Reprotox - General 1 40 79.44 Adhesions 2 58.72 Hypersensitivity 6 58.24 Prostate Cancer 1 50.00 Apoptosis 57 45.44 Cancer 21 42.88 Hyperplasia 5 41.68 Metastasis 6 31.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Figure 1B shows the expression of XRCC1 protein in the control (scramble) and XRCC1-knockdown (XKD) shRNA replicating cells.

Positive_regulation (shows) of Gene_expression (expression) of XRCC1

1) Confidence 0.50 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.15 Pain Relevance 0

Figure 1B shows the expression of XRCC1 protein in the control (scramble) and XRCC1-knockdown (XKD) shRNA replicating cells.

Positive_regulation (shows) of Gene_expression (expression) of XRCC1

2) Confidence 0.50 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2528184 Disease Relevance 0.16 Pain Relevance 0

Irradiation during this refractory period does not increase the expression of XRCC1 or ERCC1.

Positive_regulation (increase) of Gene_expression (expression) of XRCC1

3) Confidence 0.45 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.07 Pain Relevance 0

Radiation exposed DU145 cells had increased production of DNA repair proteins, XRCC1 and ERCC1 by ERK related mechanisms [42].

Positive_regulation (increased) of Gene_expression (production) of XRCC1

4) Confidence 0.16 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.22 Pain Relevance 0

General Comments

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