INT12131

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Context Info
Confidence 0.77
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 9.42
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (POR) oxidoreductase activity (POR) endoplasmic reticulum (POR)
enzyme binding (POR)
Anatomy Link Frequency
liver 5
1A2 3
plasma 1
CPA 1
heart 1
POR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 97 99.78 Very High Very High Very High
ketamine 5 99.60 Very High Very High Very High
cytokine 23 99.08 Very High Very High Very High
ischemia 36 96.96 Very High Very High Very High
lidocaine 5 96.96 Very High Very High Very High
Paracetamol 11 94.64 High High
Dismenorea 1 86.44 High High
opiate 1 85.28 High High
Morphine 1 85.00 Quite High
Inflammatory response 26 76.00 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 32 99.98 Very High Very High Very High
Glioma 18 99.86 Very High Very High Very High
INFLAMMATION 137 99.78 Very High Very High Very High
Cancer 75 99.56 Very High Very High Very High
Critical Illness 20 99.38 Very High Very High Very High
Severe Combined Immunodeficiency 3 97.88 Very High Very High Very High
Myocardial Infarction 55 97.60 Very High Very High Very High
Necrosis 8 97.52 Very High Very High Very High
Coronary Artery Disease 109 97.44 Very High Very High Very High
Cardiovascular Disease 16 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three human cytochrome P450s, 3A4, 2C9 and 1A2, were each co-expressed with NADPH-P450 reductase in Escherichia coli and used in the preparative synthesis of drug metabolites.
Gene_expression (expressed) of NADPH-P450 reductase in 1A2
1) Confidence 0.77 Published 2005 Journal J. Ind. Microbiol. Biotechnol. Section Abstract Doc Link 15739102 Disease Relevance 0 Pain Relevance 0
Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.
Gene_expression (synthesis) of NADPH-P450 reductase in 1A2
2) Confidence 0.77 Published 2005 Journal J. Ind. Microbiol. Biotechnol. Section Title Doc Link 15739102 Disease Relevance 0.06 Pain Relevance 0.11
Immediate CPR was successful but she was hemodynamically unstable and signs of right heart strain was obvious.
Gene_expression (successful) of CPR in heart associated with sprains and strains
3) Confidence 0.65 Published 2009 Journal Middle East J Anesthesiol Section Abstract Doc Link 19583089 Disease Relevance 0.77 Pain Relevance 0.23
METHODS: Urinary C-peptide (CPR) excretion and fasting plasma glucagon levels in patients with pancreatic diabetes owing to calcific pancreatitis (19 cases) and owing to noncalcific pancreatitis (14 cases) were studied in comparison with those in patients with insulin-dependent diabetes mellitus (IDDM, 23 cases), noninsulin-dependent diabetes (NIDDM, 18 cases), and in healthy controls (11 cases).
Gene_expression (excretion) of CPR in plasma
4) Confidence 0.65 Published 1996 Journal Int. J. Pancreatol. Section Body Doc Link 9013277 Disease Relevance 0.26 Pain Relevance 0
Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.
Gene_expression (expressed) of NADPH-P450 reductase in 1A2
5) Confidence 0.60 Published 2005 Journal J. Ind. Microbiol. Biotechnol. Section Title Doc Link 15739102 Disease Relevance 0.06 Pain Relevance 0.11
When these liver microsomes were incubated with different concentrations of etomidate, dose-dependent inhibition of ketamine N-demethylation, a cytochrome P-450-dependent enzymatic process, was produced.
Gene_expression (produced) of cytochrome P-450-dependent in liver associated with ketamine
6) Confidence 0.49 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3377236 Disease Relevance 0 Pain Relevance 0.12
The data are consistent with the generation of cytochrome P-450-dependent reactive metabolites which subsequently can be detoxified by glutathione.
Gene_expression (generation) of cytochrome P-450-dependent
7) Confidence 0.44 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3385648 Disease Relevance 0.48 Pain Relevance 0.32
A review of the literature revealed only eight case reports of using BIS monitoring during CPR published in the last 6 years, but none described BIS monitoring in only one patient undergoing double cardiac resuscitation within a few days.


Gene_expression (published) of CPR
8) Confidence 0.37 Published 2008 Journal Int J Emerg Med Section Body Doc Link PMC2657270 Disease Relevance 0.39 Pain Relevance 0
The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes. 9-fold, 8-fold, and 30-fold rate increases were found respectively for nifedipine 1,4-oxidation, lidocaine N-deethylation and testosterone 6 beta-hydroxylation between P450 NF25-containing yeast microsomes from the basic strain and from the strain that both overexpresses yeast NADPH-P450 reductase and expresses human cytochrome b5.
Gene_expression (overexpress) of NADPH-P450 reductase in liver associated with sprains and strains and lidocaine
9) Confidence 0.34 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.16 Pain Relevance 0.08
The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes. 9-fold, 8-fold, and 30-fold rate increases were found respectively for nifedipine 1,4-oxidation, lidocaine N-deethylation and testosterone 6 beta-hydroxylation between P450 NF25-containing yeast microsomes from the basic strain and from the strain that both overexpresses yeast NADPH-P450 reductase and expresses human cytochrome b5.
Gene_expression (overexpresses) of NADPH-P450 reductase in liver associated with sprains and strains and lidocaine
10) Confidence 0.34 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.27 Pain Relevance 0.10
Even higher turnovers (15-fold, 20-fold and 50-fold rate increases) were obtained using P450 NF25-containing microsomes from the yeast just overexpressing yeast NADPH-P450 reductase in the presence of externally added, purified rabbit liver cytochrome b5.
Gene_expression (overexpressing) of NADPH-P450 reductase in liver
11) Confidence 0.34 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.34 Pain Relevance 0.09
In microsomes from the basic strain expressing P450 NF25, 10% of the starting P450 NF25 was transformed into this metabolite complex, whereas more than 80% of the starting P450 NF25 led to complex formation in microsomes from the strain overexpressing yeast NADPH-P450 reductase.
Gene_expression (overexpressing) of NADPH-P450 reductase associated with sprains and strains
12) Confidence 0.34 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.34 Pain Relevance 0
Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.
Gene_expression (coexpressing) of NADPH-cytochrome P450 reductase in liver
13) Confidence 0.34 Published 1992 Journal Eur. J. Biochem. Section Title Doc Link 1628642 Disease Relevance 0.11 Pain Relevance 0.06
Detection of CECs by flow-cytometry analysis and correlation with duration of CPR
Gene_expression (duration) of CPR
14) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.66 Pain Relevance 0
In this study we could also demonstrate a significant positive correlation between the CEC count and the duration of CPR.
Gene_expression (duration) of CPR
15) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.28 Pain Relevance 0.05
However, we have to state that this positive correlation is largely due to a small number of patients with a long duration of CPR with CEC values outside the data cloud.
Gene_expression (duration) of CPR
16) Confidence 0.04 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.90 Pain Relevance 0.16
mm3 sc tumors from 9L glioma cells transduced with CYP2B6 and NADHP450 reductase with CPA (140?
Gene_expression (transduced) of NADHP450 reductase in CPA associated with cancer and glioma
17) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.85 Pain Relevance 0
As result of chronic inflammation, numerous markers such as CPR (C-reactive protein), cytokines (interleukin-6 and 18, tumor necrosis factor ?)
Gene_expression (markers) of CPR associated with necrosis, inflammation, cancer and cytokine
18) Confidence 0.04 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.70 Pain Relevance 0.34
Molecular cloning and functional heterologous expression of two alleles encoding (S)-N-methylcoclaurine 3'-hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent mono-oxygenase of benzylisoquinoline alkaloid biosynthesis.
Gene_expression (expression) of cytochrome P-450-dependent
19) Confidence 0.03 Published 1998 Journal Plant J. Section Title Doc Link 9681018 Disease Relevance 0 Pain Relevance 0.17
Moreover, in critically ill patients, who did not undergo CPR, CEC counts were only slightly elevated (comparable with the levels of the CAD group; data not shown).
Gene_expression (counts) of CPR associated with coronary artery disease and critical illness
20) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 1.80 Pain Relevance 0.23

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