INT121311

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.23
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ercc1) chromosome organization (Ercc1) nucleus (Ercc1)
cytoplasm (Ercc1)
Ercc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 12 84.52 Quite High
palliative 3 58.24 Quite High
Kinase C 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Cancer 20 90.84 High High
Hypoxia 3 85.16 High High
Immunotherapy Of Cancer 3 81.88 Quite High
Reprotox - General 1 40 79.44 Quite High
Bile Duct Neoplasms 11 78.40 Quite High
Disease 9 77.32 Quite High
Cancer 69 69.56 Quite High
Adhesions 2 58.72 Quite High
Klatskin's Tumor 28 53.84 Quite High
Prostate Cancer 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Irradiation during this refractory period does not increase the expression of XRCC1 or ERCC1.
Positive_regulation (increase) of Gene_expression (expression) of ERCC1
1) Confidence 0.62 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.07 Pain Relevance 0
Overexpression of the excision repair cross-complementation group 1 (ERCC1) gene, which is crucial in the repair of cisplatin-induced DNA adducts, has been reported to negatively influence to effectiveness of cisplatin-based chemotherapy [4].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ERCC1
2) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.89 Pain Relevance 0.21
Radiation exposed DU145 cells had increased production of DNA repair proteins, XRCC1 and ERCC1 by ERK related mechanisms [42].
Positive_regulation (increased) of Gene_expression (production) of ERCC1
3) Confidence 0.21 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.27 Pain Relevance 0

General Comments

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