INT121317

Context Info Confidence 0.07 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0

nucleus (Tgfb1, Xrcc1) intracellular (Xrcc1) enzyme binding (Tgfb1) cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)

Tgfb1 (Mus musculus) Xrcc1 (Mus musculus)

Pain Link Frequency Relevance Heat palliative 1 50.00

Disease Link Frequency Relevance Heat Reprotox - General 1 1 76.72 Prostate Cancer 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blockade of the EGFR with the tyrphostin AG1478 eliminates the up-regulation XRCC1 and ERCC1 by TGF alpha or irradiation.

TGF Positive_regulation (up-regulation) of XRCC1

1) Confidence 0.07 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15355899 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.