INT12132

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Context Info
Confidence 0.31
First Reported 1992
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.96
Pain Relevance 0.27

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mitochondrion (POR) oxidoreductase activity (POR) endoplasmic reticulum (POR)
enzyme binding (POR)
Anatomy Link Frequency
liver 6
CPA 2
POR (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 4 96.96 Very High Very High Very High
Glutamate 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 24 99.98 Very High Very High Very High
Glioma 18 99.86 Very High Very High Very High
Cancer 59 99.56 Very High Very High Very High
Severe Combined Immunodeficiency 3 97.88 Very High Very High Very High
Colon Cancer 16 90.12 High High
Apoptosis 5 53.28 Quite High
Suicidal Behaviour 7 50.00 Quite Low
Pancreatic Cancer 1 34.00 Quite Low
Hypoxia 3 9.68 Low Low
Cold Sores 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In microsomes from the basic strain expressing P450 NF25, 10% of the starting P450 NF25 was transformed into this metabolite complex, whereas more than 80% of the starting P450 NF25 led to complex formation in microsomes from the strain overexpressing yeast NADPH-P450 reductase.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NADPH-P450 reductase associated with sprains and strains
1) Confidence 0.31 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.34 Pain Relevance 0
Even higher turnovers (15-fold, 20-fold and 50-fold rate increases) were obtained using P450 NF25-containing microsomes from the yeast just overexpressing yeast NADPH-P450 reductase in the presence of externally added, purified rabbit liver cytochrome b5.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NADPH-P450 reductase in liver
2) Confidence 0.31 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.34 Pain Relevance 0.09
The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes. 9-fold, 8-fold, and 30-fold rate increases were found respectively for nifedipine 1,4-oxidation, lidocaine N-deethylation and testosterone 6 beta-hydroxylation between P450 NF25-containing yeast microsomes from the basic strain and from the strain that both overexpresses yeast NADPH-P450 reductase and expresses human cytochrome b5.
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of NADPH-P450 reductase in liver associated with sprains and strains and lidocaine
3) Confidence 0.31 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.27 Pain Relevance 0.10
The availability of recently developed host cells that simultaneously overexpress yeast NADPH-P450 reductase and/or express human liver cytochrome b5, obtained through stable integration of the corresponding coding sequences into the yeast genome, led to biotechnological systems with much higher activities of yeast-expressed P450 NF25 and with much better ability to form P450 NF25-iron-metabolite complexes. 9-fold, 8-fold, and 30-fold rate increases were found respectively for nifedipine 1,4-oxidation, lidocaine N-deethylation and testosterone 6 beta-hydroxylation between P450 NF25-containing yeast microsomes from the basic strain and from the strain that both overexpresses yeast NADPH-P450 reductase and expresses human cytochrome b5.
Positive_regulation (overexpress) of Gene_expression (overexpress) of NADPH-P450 reductase in liver associated with sprains and strains and lidocaine
4) Confidence 0.31 Published 1992 Journal Eur. J. Biochem. Section Abstract Doc Link 1628642 Disease Relevance 0.16 Pain Relevance 0.08
mm3 sc tumors from 9L glioma cells transduced with CYP2B6 and NADHP450 reductase with CPA (140?
Positive_regulation (with) of Gene_expression (transduced) of NADHP450 reductase in CPA associated with cancer and glioma
5) Confidence 0.03 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.85 Pain Relevance 0

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