INT12133

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Context Info
Confidence 0.03
First Reported 1981
Last Reported 1992
Negated 0
Speculated 3
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.57
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
pituitary 6
plasma 2
pituitary gland 2
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 99.68 Very High Very High Very High
Morphine 2 95.96 Very High Very High Very High
Opioid 5 95.24 Very High Very High Very High
halothane 4 95.20 Very High Very High Very High
Intracerebroventricular 1 94.08 High High
Clonidine 8 90.68 High High
anesthesia 12 85.08 High High
antagonist 2 81.96 Quite High
Analgesic 2 78.40 Quite High
dexamethasone 2 72.16 Quite High
Disease Link Frequency Relevance Heat
Stress 6 99.84 Very High Very High Very High
Pain 2 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of several anesthetic drugs and artificial respiration on the release of pituitary beta-endorphin-like immunoreactivity (beta-END-LI) were examined in rats.
Spec (examined) Regulation (effects) of Localization (release) of beta-END in pituitary
1) Confidence 0.03 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6328533 Disease Relevance 0 Pain Relevance 0.34
Treatment with morphine (1 or 5 mg/kg), but not pancuronium (0.3 mg/kg), attenuated the plasma beta-END-LI response to mechanical ventilation, suggesting that a subconscious phenomenon, perhaps related to pain, was partially responsible for the profound release of pituitary beta-END-LI associated with artificial respiration.
Spec (partially) Regulation (responsible) of Localization (release) of beta-END in pituitary associated with pain and morphine
2) Confidence 0.02 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6328533 Disease Relevance 0.10 Pain Relevance 0.77
In the second series of experiments the release of beta-End from the IN-ME and pituitary gland was altered by stress.
Regulation (altered) of Localization (release) of beta-End in pituitary gland associated with stress
3) Confidence 0.01 Published 1992 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 1628696 Disease Relevance 0.47 Pain Relevance 0.42
Parallel measurements of plasma alpha-melanotropin-like immunoreactivity (alpha-MSH-LI) and beta-endorphin-like immunoreactivity (beta-END-LI) were used to examine the differential adrenergic control of beta-END secretion from the anterior lobe (AL) versus the intermediate lobe (IL) of the rat pituitary gland in vivo.
Spec (examine) Regulation (control) of Localization (secretion) of beta-END in plasma
4) Confidence 0.01 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6326157 Disease Relevance 0 Pain Relevance 0.10
These data suggest an alpha-adrenergic mechanism influences the release of pituitary beta-END in the rat.
Regulation (influences) of Localization (release) of pituitary beta-END in pituitary
5) Confidence 0.01 Published 1981 Journal Endocrinology Section Abstract Doc Link 6266807 Disease Relevance 0 Pain Relevance 0.61

General Comments

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