INT121334

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.66
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
vesicle 2
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 7 99.84 Very High Very High Very High
cva 13 75.76 Quite High
Pyramidal cell 16 72.88 Quite High
depression 8 69.76 Quite High
cerebral cortex 6 65.28 Quite High
Pain 46 64.48 Quite High
ischemia 9 60.64 Quite High
guanethidine 1 57.68 Quite High
Analgesic 4 44.56 Quite Low
Neuritis 2 38.24 Quite Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 21 100.00 Very High Very High Very High
Injury 1077 99.96 Very High Very High Very High
Disease 77 99.54 Very High Very High Very High
Burns 330 99.20 Very High Very High Very High
Toxicity 45 97.88 Very High Very High Very High
Neurological Disease 3 95.12 Very High Very High Very High
Epilepsy 2 94.68 High High
Neurodegenerative Disease 15 88.32 High High
Body Weight 14 87.44 High High
Atherosclerosis 4 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nuclear receptor corepressor I has been suggested to play a role in Huntington’s disease because it is able to interact with huntingtin (41).
huntingtin Binding (interact) of associated with disease
1) Confidence 0.47 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.53 Pain Relevance 0
The protein encoded by the HD gene, htt (huntingtin), is normally a cytoplasmic protein closely associated with vesicle membranes and microtubules.
htt Binding (associated) of in vesicle
2) Confidence 0.36 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.77 Pain Relevance 0.14
The protein encoded by the HD gene, htt (huntingtin), is normally a cytoplasmic protein closely associated with vesicle membranes and microtubules.
huntingtin Binding (associated) of in vesicle
3) Confidence 0.36 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.77 Pain Relevance 0.14
This protective effect of trehalose was suggested to be mediated by its ability to act as a chemical chaperone through its binding to the polyQ-expanded mutant huntingtin and influencing its protein folding and aggregation.
huntingtin Binding (binding) of
4) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.39 Pain Relevance 0
Hexane extractions for HD
HD Binding (extractions) of
5) Confidence 0.07 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.09 Pain Relevance 0
Hexane extractions for HD
HD Binding (extractions) of
6) Confidence 0.07 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.30 Pain Relevance 0
This may imply that the cytotoxic effects of HD are mediated via interaction with cell surface components rather than intracellular targets.
HD Binding (interaction) of
7) Confidence 0.06 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.08 Pain Relevance 0.06
Alternatively, HD may also react directly with protein thiols to cause the inactivation of enzymes.
HD Binding (react) of
8) Confidence 0.04 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0
The fluids used in replacement fluid therapy for non-HD burns, which would likely be appropriate for use in HD injuries if fluid replacement is required, are described by Settle,80 Brisebois,81 and Thomas et al.82
HD Binding (use) of associated with burns and injury
9) Confidence 0.04 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 1.27 Pain Relevance 0
Thus, further investigations of the interaction of cell-surface molecules with HD may provide a new insight into the mechanisms of HD toxicity.


HD Binding (interaction) of associated with toxicity
10) Confidence 0.04 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.10 Pain Relevance 0.06
Adrenergic actions can also cause the abnormal lipid metabolism that is associated with CAD and IsHD by catecholamine-induced metabolic actions on lipid mobilization by activation of phospholipases.
IsHD Binding (associated) of associated with coronary artery disease and catecholamine
11) Confidence 0.01 Published 2004 Journal Am J Ther Section Abstract Doc Link 15356432 Disease Relevance 2.36 Pain Relevance 0.38

General Comments

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