INT121336

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 10.88
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
skin 2
stem cell 1
body 1
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 10 90.96 High High
Pain 58 84.28 Quite High
cva 13 81.60 Quite High
Catecholamine 7 58.96 Quite High
palliative 3 44.56 Quite Low
Analgesic 5 29.04 Quite Low
guanethidine 1 25.00 Low Low
imagery 92 5.00 Very Low Very Low Very Low
Inflammation 60 5.00 Very Low Very Low Very Low
cINOD 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 84 100.00 Very High Very High Very High
Coronary Artery Disease 21 100.00 Very High Very High Very High
Injury 1070 99.96 Very High Very High Very High
Epstein-barr Virus 22 99.84 Very High Very High Very High
Heart Rate Under Development 15 99.54 Very High Very High Very High
Cytomegalovirus Infection 36 99.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 99.28 Very High Very High Very High
Pressure Volume 2 Under Development 15 99.14 Very High Very High Very High
Heart Disease 2 98.48 Very High Very High Very High
Neurodegenerative Disease 1 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene product huntingtin is widely distributed in both neurones and extraneuronal tissues.
Positive_regulation (distributed) of huntingtin
1) Confidence 0.45 Published 2004 Journal J Neural Transm Section Abstract Doc Link 15480847 Disease Relevance 0.52 Pain Relevance 0
In our opinion, the rapid onset of HD after HSCT (+105 day), the clinical and the histopathological characteristics are consistent with a rare presentation of HD as EBV-negative PTLD.
Positive_regulation (onset) of HD associated with cytomegalovirus infection, epstein-barr virus and disease
2) Confidence 0.12 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208867 Disease Relevance 2.19 Pain Relevance 0
In our opinion, the rapid onset of HD after HSCT (+105 day), the clinical and the histopathological characteristics are consistent with a rare presentation of HD as EBV-negative PTLD.
Positive_regulation (presentation) of HD associated with cytomegalovirus infection, epstein-barr virus and disease
3) Confidence 0.12 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1208867 Disease Relevance 2.01 Pain Relevance 0
The best agent will be the one that not only decontaminates HD sitting on the surface of the skin, but also is capable of fully penetrating the stratum corneum and neutralizing any unbound agent reservoir located there, unlike previous reactive therapies.68 Research is underway to develop an in vitro model for efficacy testing of advanced decontaminating agents capable of pulling HD out of the skin reservoir and neutralizing HD on the surface of the skin, to identify the most appropriate animal model for extrapolation of animal data to humans, and to conduct in vivo efficacy tests of candidate decontamination systems.


Positive_regulation (pulling) of HD in skin
4) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0.08
Glutathione is an intracellular scavenger of HD, which may be the cause of GSH depletion.
Positive_regulation (scavenger) of HD
5) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0
The best agent will be the one that not only decontaminates HD sitting on the surface of the skin, but also is capable of fully penetrating the stratum corneum and neutralizing any unbound agent reservoir located there, unlike previous reactive therapies.68 Research is underway to develop an in vitro model for efficacy testing of advanced decontaminating agents capable of pulling HD out of the skin reservoir and neutralizing HD on the surface of the skin, to identify the most appropriate animal model for extrapolation of animal data to humans, and to conduct in vivo efficacy tests of candidate decontamination systems.


Positive_regulation (neutralizing) of HD in skin
6) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0.08
Medical personnel are cautioned not to overhydrate the patient; hypervolemia and pulmonary edema can be iatrogenically induced in HD casualties.15,44 Fluid requirements in Iranian casualties during the Iran-Iraq war appeared to have been relatively independent of TBSA.44 The recommended infusion rates and formulas used to calculate total volume requirements for thermal burn patients, based on body weight and TBSA,80 should not be routinely applied in HD casualty management.
Positive_regulation (induced) of HD in body associated with heart rate under development, body weight, pressure volume 2 under development and burns
7) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 1.43 Pain Relevance 0
The exact fluid replacement requirements for cutaneous HD injuries should be based on patient status and considered on a case-by-case basis.
Positive_regulation (requirements) of HD associated with injury
8) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 1.24 Pain Relevance 0
The clinical study and review presented herein suggest that adrenergic hyperactivity alone without CAD can be a primary cause of IsHD.
Positive_regulation (cause) of IsHD associated with coronary artery disease and attention deficit hyperactivity disorder
9) Confidence 0.01 Published 2004 Journal Am J Ther Section Abstract Doc Link 15356432 Disease Relevance 2.91 Pain Relevance 0.44
Two retrospective analyses suggest that G-CSF treatment after allogeneic stem cell transplant may have a negative impact on outcome with increased risk of GvHD and reduced survival [10, 12].
Positive_regulation (increased) of GvHD in stem cell associated with disease
10) Confidence 0.01 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2710993 Disease Relevance 0.58 Pain Relevance 0

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