INT121337

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 12.91
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HEY1) protein binding transcription factor activity (HEY1) DNA binding (HEY1)
transcription factor binding (HEY1) cytoplasm (HEY1)
Anatomy Link Frequency
plasma 1
blood 1
HEY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 705 100.00 Very High Very High Very High
cytokine 163 95.24 Very High Very High Very High
Catecholamine 7 95.20 Very High Very High Very High
Inflammation 113 88.64 High High
imagery 28 87.44 High High
Etanercept 40 81.36 Quite High
Pain 12 74.24 Quite High
Bioavailability 3 63.68 Quite High
antagonist 17 62.96 Quite High
guanethidine 1 62.84 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 960 100.00 Very High Very High Very High
Rheumatoid Arthritis 715 100.00 Very High Very High Very High
Frailty 195 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 82 100.00 Very High Very High Very High
Natriuresis 43 100.00 Very High Very High Very High
Necrosis 13 100.00 Very High Very High Very High
Heart Rate Under Development 7 100.00 Very High Very High Very High
Shock 1 100.00 Very High Very High Very High
Myocardial Infarction 34 97.20 Very High Very High Very High
Coronary Heart Disease 91 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factors contributing to the decrease in CHF mortality include improved access to care, the introduction of effective therapies, and improved care of comorbid conditions [15].
Negative_regulation (decrease) of CHF associated with cv general 4 under development
1) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.32 Pain Relevance 0.05
Considering only TNF inhibitor treated patients, a 50% reduction in CHF hospitalizations was observed.
Negative_regulation (reduction) of CHF associated with cv general 4 under development
2) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.24 Pain Relevance 0.38
Risk factors, echocardiographic predictors, and biochemical markers associated with the development of CHF: relationship to RA
Negative_regulation (development) of CHF associated with cv general 4 under development and rheumatoid arthritis
3) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.06 Pain Relevance 0.46
This lack of decline in CHF incidence among men is largely attributable to advances in the management of acute myocardial infarction, diabetes, and hypertension that have led to an overall decrease in mortality rates from these disorders while adding to the incidence of CHF [23].
Negative_regulation (decline) of CHF associated with pressure and volume under development, diabetes mellitus, cv general 4 under development and myocardial infarction
4) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 1.14 Pain Relevance 0
The epidemiology of CHF in RA, and the limitations of the available data, are better appreciated in the context of estimates of CHF in the general population.
Negative_regulation (appreciated) of CHF associated with cv general 4 under development and rheumatoid arthritis
5) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 2.24 Pain Relevance 0.62
This report shows how prophylactic bretylium not only prevents arrhythmias but prevents myocardial necrosis, shock, CHF, maintains or restores normal contractility, and lowers mortality in AMI patients by inducing adrenergic blockade.
Negative_regulation (prevents) of CHF associated with heart rate under development, necrosis, shock and myocardial infarction
6) Confidence 0.10 Published 2004 Journal Am J Ther Section Abstract Doc Link 15356432 Disease Relevance 2.37 Pain Relevance 0.23
In detail, the lack of ACh/SNP differentiation for CHF in interval VI can be explained by the fact that the response to ACh is significantly decreased in CHF compared to HC (Fig. 7a) while the SNP response is not (Fig. 7b).
Negative_regulation (decreased) of CHF associated with frailty
7) Confidence 0.02 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 1.16 Pain Relevance 0.09
The endothelium plays a pivotal role in regulating blood flow by releasing relaxing and constricting factors, a role that has been shown to be impaired in CHF (Drexler et al., 1992; Vanhoutte, 1996; Morgan et al., 2004).
Negative_regulation (impaired) of CHF in blood associated with frailty
8) Confidence 0.02 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 0.56 Pain Relevance 0.03
Indeed, impaired endothelium-dependent vasodilatation and increased plasma concentration of a variety of neurohormones e.g. endothelin, angiotensin II, and natriuretic peptides in CHF, have been previously described (Vanhoutte, 1996).
Negative_regulation (impaired) of CHF in plasma associated with natriuresis, frailty and increased venous pressure under development
9) Confidence 0.02 Published 2008 Journal Microvasc Res Section Body Doc Link PMC2666799 Disease Relevance 0.81 Pain Relevance 0.03

General Comments

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