INT121338

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.41
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTUS1) Golgi apparatus (MTUS1) plasma membrane (MTUS1)
cytoskeleton (MTUS1) nucleus (MTUS1) microtubule organizing center (MTUS1)
Anatomy Link Frequency
plasma 1
MTUS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 17 99.72 Very High Very High Very High
headache 1 64.00 Quite High
addiction 1 49.52 Quite Low
fibrosis 1 22.08 Low Low
cytokine 42 5.00 Very Low Very Low Very Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 24 5.00 Very Low Very Low Very Low
Potency 18 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 250 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Renal Disease 3 99.98 Very High Very High Very High
Muscle Disease 2 99.98 Very High Very High Very High
Cold Sores 367 99.58 Very High Very High Very High
Muscle Weakness 1 96.88 Very High Very High Very High
Myalgia 1 96.20 Very High Very High Very High
Infection 214 96.08 Very High Very High Very High
Cytochrome-c Oxidase Deficiency 1 87.48 High High
Lactic Acidosis 1 85.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WT1 is a tumor-suppressor gene that encodes a protein, which mediates transcriptional repression and interacts with p53 protein [18], product of another tumor suppressor gene, TP53, frequently deleted or mutated in many human tumors.
tumor-suppressor gene Binding (interacts) of associated with cancer and repression
1) Confidence 0.07 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.45 Pain Relevance 0
Pure myopathy associated with a novel mitochondrial tRNA gene mutation.
mitochondrial tRNA gene Binding (associated) of associated with pain and muscle disease
2) Confidence 0.06 Published 2006 Journal Neurology Section Title Doc Link 16476954 Disease Relevance 0.47 Pain Relevance 0.10
For those viruses that fuse with cell membranes at the cell surface, like HPIV, HeV, and NiV, the receptor-binding protein binds to cellular surface receptors, brings the viral envelope in proximity to the plasma membrane, and activates the viral F protein to undergo the required conformational changes leading to fusion.
receptor-binding protein Binding (binds) of in plasma
3) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2965769 Disease Relevance 0.78 Pain Relevance 0
Each step, from the interaction of the receptor-binding protein with its receptor and the subsequent triggering of the fusion protein, to the conformational changes in the fusion protein that lead to fusion readiness, and the refolding of the fusion protein that drives membrane merger, are potential targets for antiviral compounds.
receptor-binding protein Binding (interaction) of
4) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2965769 Disease Relevance 0.06 Pain Relevance 0
Entry of HSV into cells involves interactions between the viral receptor-binding protein gD and the gD receptors.
viral receptor-binding protein gD Binding (interactions) of associated with cold sores
5) Confidence 0.01 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.62 Pain Relevance 0
Our data however indicate that uncleaved F0 – only upon receptor engagement of the receptor binding protein, HN — undergoes conformational changes sufficient to expose the HRN domain to inhibitors.
receptor binding protein Binding (engagement) of
6) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2965769 Disease Relevance 0 Pain Relevance 0
Progressive nephropathy associated with mitochondrial tRNA gene mutation.
mitochondrial tRNA gene Binding (associated) of associated with renal disease
7) Confidence 0.00 Published 2004 Journal Clin. Nephrol. Section Title Doc Link 15356973 Disease Relevance 1.04 Pain Relevance 0.06

General Comments

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