INT12135

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 34.13
Pain Relevance 12.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 50
coronary artery 2
blood 2
endothelial cells 2
macrophages 1
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
5HT 166 100.00 Very High Very High Very High
antagonist 42 100.00 Very High Very High Very High
gABA 9 100.00 Very High Very High Very High
Serotonin 14 99.96 Very High Very High Very High
Angina 67 99.88 Very High Very High Very High
aspirin 546 99.84 Very High Very High Very High
agonist 118 99.82 Very High Very High Very High
Pain 20 99.44 Very High Very High Very High
Hippocampus 68 99.40 Very High Very High Very High
substance P 2 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 183 100.00 Very High Very High Very High
Stress 101 99.92 Very High Very High Very High
Cv General 3 Under Development 91 99.88 Very High Very High Very High
Disorder Of Lipid Metabolism 162 99.50 Very High Very High Very High
Increased Venous Pressure Under Development 61 99.32 Very High Very High Very High
Thrombosis 145 99.28 Very High Very High Very High
Schizophrenia 80 99.20 Very High Very High Very High
Acute Coronary Syndrome 99 99.16 Very High Very High Very High
Acute Liver Failure 8 99.16 Very High Very High Very High
Hemorrhage 131 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PMP express most of the platelet membrane proteins, therefore likely including MT-1 MMP, which was notable in the study [51].
Gene_expression (express) of platelet in platelet
1) Confidence 0.75 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.56 Pain Relevance 0.16
CONCLUSIONS: Increased expression of platelet genes in patients with migraine and CM suggests similar underlying pathophysiology.
Gene_expression (expression) of platelet in platelet
2) Confidence 0.75 Published 2004 Journal Headache Section Body Doc Link 15546262 Disease Relevance 0 Pain Relevance 0
There was no significantly different in platelet GP IIb/IIIa expression after the antiplatelet therapy in patients with unstable angina.


Neg (no) Gene_expression (expression) of platelet in platelet
3) Confidence 0.75 Published 2005 Journal Pol. Merkur. Lekarski Section Body Doc Link 15859538 Disease Relevance 0.06 Pain Relevance 0
However, there was a highly significant increase of platelet activity as assessed by conventional aggregometry (P=.0003), Ultegra analyzer readings (P=.03), and expression of GPIIb/IIIa (P=.02), P-selectin (P=.03), and platelet endothelial cell adhesion molecule-1 (P=.001) after withdrawal from NSAIDs and COX-2 inhibitors.
Spec (analyzer) Gene_expression (expression) of platelet in platelet
4) Confidence 0.75 Published 2006 Journal Am. J. Med. Section Body Doc Link 16887419 Disease Relevance 0 Pain Relevance 0
In addition, the association of platelet P-selectin expression and automated red cell exchange was independent of other laboratory factors (hematocrit level, hemoglobin S level, platelet count, and nitric oxide level).
Gene_expression (expression) of platelet in platelet
5) Confidence 0.75 Published 2007 Journal Ther Apher Dial Section Abstract Doc Link 17661830 Disease Relevance 0.19 Pain Relevance 0.08
However, the association of platelet P-selectin expression and automated red cell exchange procedures in these patients is not well known.
Gene_expression (expression) of platelet in platelet
6) Confidence 0.75 Published 2007 Journal Ther Apher Dial Section Abstract Doc Link 17661830 Disease Relevance 0.25 Pain Relevance 0.05
We assessed prostanoid metabolite excretion (PGE-M, TXB(2), 6-keto-PGF(1alpha), 11-dehydro-TXB(2), 2,3-dinor-TXB(2), and dinor-6-keto-PGF(1alpha)), the expression of platelet activation markers (CD62P, PAC-1, fibrinogen), platelet-leukocyte formation, the endogenous thrombin potential, platelet cAMP content and plasma thrombomodulin level.
Gene_expression (expression) of platelet in leukocyte
7) Confidence 0.75 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0
None of the coxibs exerted significant effects on the expression of platelet activation markers, cAMP generation, platelet-leukocyte formation, or on thrombomodulin plasma levels.
Gene_expression (expression) of platelet in platelet
8) Confidence 0.75 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0
HDL inhibit agonist-induced production of platelet-activating factor (PAF), a bioactive phospholipid that stimulates cell adhesion, platelet aggregation, and vascular permeability in endothelial cells (Sugatani et al 1996).
Gene_expression (production) of platelet in endothelial cells associated with agonist, adhesions and disorder of lipid metabolism
9) Confidence 0.75 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.27 Pain Relevance 0.05
Because of the relatively weak antiplatelet effects of aspirin, agonists such as thrombin, collagen, and serotonin can induce the functional expression of the platelet GP IIb/IIIa receptor.
Gene_expression (expression) of platelet in platelet associated with aspirin, agonist and serotonin
10) Confidence 0.75 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.49 Pain Relevance 0.29
There is a non-linear relationship between inhibition of platelet TXA2 generation and inhibition of TXA2-dependent platelet aggregation.
Gene_expression (generation) of platelet in platelet
11) Confidence 0.75 Published 2004 Journal Thromb J Section Body Doc Link PMC331420 Disease Relevance 0.12 Pain Relevance 0.41
For the first time we find that increased platelet P2Y12 receptor protein expression is a component of clopidogrel resistance.
Gene_expression (expression) of platelet in platelet
12) Confidence 0.75 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.15 Pain Relevance 0.20
Diabetes was associated with an increase in plaque area and complexity in the aorta, in association with a significant increase in aortic AT-1 receptor expression, cellular proliferation, collagen content, and macrophage-positive and alpha-smooth muscle actin-positive cell infiltration, as well as an increased expression of platelet-derived growth factor-B (PDGF-B), monocyte chemoattractant protein-1 (MCP-1), and vascular cell adhesion molecule-1 (VCAM-1).
Gene_expression (expression) of platelet in smooth muscle associated with diabetes mellitus, adhesions and hyperplasia
13) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.82 Pain Relevance 0.06
Nowadays, blockade of the most important and highly expressed platelet receptor, the fibrinogen-binding integrin receptor GPIIb/IIIa (or ???
Gene_expression (expressed) of platelet in platelet
14) Confidence 0.75 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.36 Pain Relevance 0.07
However, when BDNF level was determined in platelets, it was found that platelet BDNF levels were lower in both nonsuicidal and suicidal depressed patients compared with healthy controls, whereas no significant differences were noted between nonsuicidal and suicidal depressed patients.188 Interestingly, Dawood et al189 used direct internal jugular vein blood sampling methods to circumvent the issue of whether BDNF is released from other sources than the brain and they examined the relationship between brain BDNF production and suicide risk in untreated patients with depression.
Gene_expression (levels) of platelet in blood associated with suicidal behaviour and depression
15) Confidence 0.75 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.19 Pain Relevance 0.14
Oral bacteria including Streptococcus sanguis and P. gingivalis have been shown to result in the expression of platelet aggregation proteins that may play a role in the formation of atheromas and thrombi possibly contributing to vascular disease (Herzberg and Meyer 1996, 1998; Sharma et al 2000; Pham et al 2002).
Gene_expression (expression) of platelet in platelet associated with atherosclerosis and increased venous pressure under development
16) Confidence 0.75 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626915 Disease Relevance 1.12 Pain Relevance 0.22
Platelets express platelet-specific antigens and HLA class I antigens.
Gene_expression (express) of platelet in platelet
17) Confidence 0.75 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.76 Pain Relevance 0
Main outcome measures Main outcome measures were (1) H pylori serology using ELISA kit for immunoglobulin G antibody to H pylori and (2) whole blood flow cytometric analysis of resting platelet P-selectin expression and fibrinogen binding as measures of platelet activation.
Gene_expression (expression) of platelet in blood associated with ulcers
18) Confidence 0.75 Published 2004 Journal J. Vasc. Surg. Section Abstract Doc Link 14981449 Disease Relevance 0.97 Pain Relevance 0.31
The expression of platelet receptors was determined by using the following monoclonal antibodies: CD31 (PECAM-1), CD41 (GPIIb), CD42b (GPIb), CD51/CD61 (vitronectin receptor), CD62p (P-selectin), CD63 (LIMP or LAMP-3), CD107a (LAMP-1), CD151 (PETA-3), and PAC-1 for fibrinogen-platelet binding determination (PharMingen, San Diego, CA).
Gene_expression (expression) of platelet in platelet
19) Confidence 0.75 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.09 Pain Relevance 0
Platelet activating factor (PAF) is known to produce a wide variety of hemodynamic effects.
Gene_expression (produce) of Platelet in Platelet
20) Confidence 0.75 Published 1997 Journal J Smooth Muscle Res Section Abstract Doc Link 9533823 Disease Relevance 0 Pain Relevance 0.26

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