INT121370

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 17.79
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
Macrophage 3
granulocyte 1
colon 1
B lymphocytes 1
melanocytes 1
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 828 100.00 Very High Very High Very High
cytokine 856 99.96 Very High Very High Very High
rheumatoid arthritis 109 99.68 Very High Very High Very High
antagonist 12 99.44 Very High Very High Very High
spinal inflammation 15 99.28 Very High Very High Very High
Arthritis 181 98.36 Very High Very High Very High
Inflammatory response 67 97.04 Very High Very High Very High
aspirin 10 96.48 Very High Very High Very High
Inflammatory marker 13 94.92 High High
chemokine 24 93.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 917 100.00 Very High Very High Very High
Colorectal Cancer 190 99.84 Very High Very High Very High
Cancer 163 99.84 Very High Very High Very High
Rheumatoid Arthritis 110 99.68 Very High Very High Very High
Hypoxia 115 99.60 Very High Very High Very High
Malaria 1050 99.52 Very High Very High Very High
Skin Cancer 20 99.48 Very High Very High Very High
Low Back Pain 18 99.28 Very High Very High Very High
Sprains And Strains 23 99.16 Very High Very High Very High
Colon Cancer 18 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, MIF levels seemed to be particularly elevated in women with endometriosis who were infertile and who suffered from pelvic pain.
Positive_regulation (elevated) of MIF
1) Confidence 0.70 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616746 Disease Relevance 0.07 Pain Relevance 0
It has been suggested, that a multitude of autoimmune/inflammatory/neoplastic disease states might benefit from therapeutic measures, targeting MIF.
Spec (might) Positive_regulation (targeting) of MIF associated with inflammation and cancer
2) Confidence 0.49 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19275614 Disease Relevance 0.53 Pain Relevance 0.27
Of note is the significant increase in MIF levels occurring in the midsecretory phase in women with endometriosis as compared with controls, particularly in infertile patients, as well as in the late secretory phase preceding menstruation.
Positive_regulation (increase) of MIF
3) Confidence 0.47 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616746 Disease Relevance 0.08 Pain Relevance 0
The unique induction of MIF that takes place at low glucocorticoid concentrations, together with its ability to counter-regulate glucocorticoid immunosuppressive actions, implies a potentially important role of MIF in the control of the immune response.
Positive_regulation (induction) of MIF
4) Confidence 0.43 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128941 Disease Relevance 0.79 Pain Relevance 0.45
In vitro, both CD and GCD induced a dramatic increase in MIF protein and mRNA in ESCC cells.
Positive_regulation (increase) of MIF protein associated with skin cancer
5) Confidence 0.43 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.91 Pain Relevance 0.42
CONCLUSION(S): This study showed a significant increase in MIF concentrations in the intrauterine endometrial tissue of women with endometriosis, occurring at specific phases of the menstrual cycle, a relationship between MIF concentrations and disease stage, and a possible role for this factor in endometriosis-associated pain and infertility.


Positive_regulation (increase) of MIF
6) Confidence 0.41 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616746 Disease Relevance 0.06 Pain Relevance 0
Western blotting demonstrated that levels of MIF protein were increased in tumors versus non-malignant tissues, with the expression ratio of MIF over beta-actin of 0.93 +/- 0.21 and 0.57 +/- 0.08, respectively (P = 0.012).
Positive_regulation (increased) of MIF protein associated with malignant neoplastic disease and cancer
7) Confidence 0.40 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.92 Pain Relevance 0.36
We have therefore studied whether serum MIF levels are elevated in patients with AS and whether the levels correlate with oxidative stress markers and disease activity parameters.
Spec (whether) Positive_regulation (elevated) of serum MIF associated with stress, spinal inflammation and disease
8) Confidence 0.30 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 2.11 Pain Relevance 0.99
The gene expression level of macrophage migration inhibitory factor (MIF) is elevated in CRC tissues, suggesting the use of the protein as a potential biomarker for CRC.
Positive_regulation (elevated) of MIF in macrophage associated with colorectal cancer
9) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.65 Pain Relevance 0
In an analysis of serum samples of 129 patients with colon cancer and 53 healthy control subjects, the serum MIF level was found to be significantly increased in patients with CRC [78].
Positive_regulation (increased) of MIF in colon associated with colorectal cancer and colon cancer
10) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.57 Pain Relevance 0
Macrophage migration inhibitory factor
Positive_regulation (Macrophage) of migration inhibitory factor in Macrophage
11) Confidence 0.27 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128941 Disease Relevance 0.70 Pain Relevance 0.46
Higher MIF levels were detected 6 h post-CPB, and returned to preoperative levels 24 h after CPB.
Positive_regulation (detected) of MIF
12) Confidence 0.27 Published 2004 Journal Shock Section Abstract Doc Link 15545824 Disease Relevance 0.11 Pain Relevance 0.18
Martiney and co-workers [212] found that MIF was enhanced in a mouse malaria model, and that rMIF inhibited the formation of erythroid (BFU-E), multipotential (CFU-GEMM), and granulocyte-macrophage (CFU-GM) progenitor-derived colonies in vitro.
Positive_regulation (enhanced) of MIF in granulocyte associated with malaria
13) Confidence 0.25 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.03 Pain Relevance 0.26
Macrophage migration inhibitory factor
Positive_regulation (Macrophage) of migration inhibitory factor in Macrophage
14) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.78 Pain Relevance 0.56
As with HIF-1, both hypoxia [273] and TNF [42] upregulate MIF.
Positive_regulation (upregulate) of MIF associated with hypoxia
15) Confidence 0.18 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.57 Pain Relevance 0.20
As an indication of the broad relevance and complexity of these cytokines and their interactions, MIF is also induced in mammals by E. coli lipopolysaccharide [42], staphylococcus toxic shock toxin, and streptococcal pyrogenic toxin A [45].
Positive_regulation (induced) of MIF associated with septic shock and cytokine
16) Confidence 0.18 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.98 Pain Relevance 0.46
Although with the absence of some key molecules in the activation of immune responses to facilitate the virus transformation, the transformed B lymphocytes from the cynomolgus monkey expressed more immunoglobulin and ligand and receptor genes than in human blood and lymph nodes, in numbers as well as in abundances; A B-cell specific proliferation pathway including MIF, CD74 and CD44 was greatly enhanced after transformation.
Positive_regulation (enhanced) of MIF in B lymphocytes
17) Confidence 0.18 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.12 Pain Relevance 0
MIF, a pro-inflammatory mediator shown to be upregulated dramatically in a number of tissues in both severe falciparum malaria and sepsis [271], also accelerates glycolysis [272], so can be expected to contribute to the hypoglycaemia and hyperlactataemia of both diseases.
Positive_regulation (upregulated) of MIF associated with hypoglycemia, malaria, inflammation, disease and sepsis
18) Confidence 0.17 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.35 Pain Relevance 0.27
Patients who presented worse pulmonary performance (ratio of partial arterial oxygen tension (PaO2) to fraction of inspired oxygen (FiO2) less than 196) exhibited higher levels of MIF three hours after CPB (p < 0.001).
Positive_regulation (levels) of MIF
19) Confidence 0.17 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.25 Pain Relevance 0.04
More recently attention has focussed on another cytokine, MIF, downstream of TNF but also induced by agents other than TNF, as a cause of malarial dyserythropoiesis.
Positive_regulation (induced) of MIF associated with cytokine
20) Confidence 0.15 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.06 Pain Relevance 0.28

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