INT121372

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 14.78
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
macrophage 4
bile 4
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 30 99.98 Very High Very High Very High
rheumatoid arthritis 88 99.96 Very High Very High Very High
aspirin 30 99.36 Very High Very High Very High
spinal inflammation 12 99.28 Very High Very High Very High
Inflammatory response 36 97.92 Very High Very High Very High
cytokine 103 97.84 Very High Very High Very High
Inflammatory marker 23 95.80 Very High Very High Very High
Inflammation 155 95.36 Very High Very High Very High
Arthritis 30 84.40 Quite High
Inflammatory mediators 28 84.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 137 100.00 Very High Very High Very High
Malignant Neoplastic Disease 12 100.00 Very High Very High Very High
Rheumatoid Arthritis 88 99.96 Very High Very High Very High
Colorectal Cancer 95 99.84 Very High Very High Very High
Skin Cancer 54 99.84 Very High Very High Very High
Low Back Pain 15 99.28 Very High Very High Very High
Infection 15 99.28 Very High Very High Very High
Disease 50 99.04 Very High Very High Very High
Sepsis 10 98.72 Very High Very High Very High
Systemic Inflammatory Response Syndrome 10 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas bile acids induce MIF expression in ESCC cells, aspirin and NS398 significantly inhibit MIF expression, even in the presence of bile acids, via a COX-independent mechanism.
Positive_regulation (induce) of Gene_expression (expression) of MIF in bile associated with aspirin, bile and skin cancer
1) Confidence 0.60 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.75 Pain Relevance 0.39
In conclusion, MIF expression is increased in ESCC.
Positive_regulation (increased) of Gene_expression (expression) of MIF associated with skin cancer
2) Confidence 0.60 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.76 Pain Relevance 0.43
Of note is the significant increase in MIF levels occurring in the midsecretory phase in women with endometriosis as compared with controls, particularly in infertile patients, as well as in the late secretory phase preceding menstruation.
Positive_regulation (increase) of Gene_expression (levels) of MIF
3) Confidence 0.50 Published 2006 Journal Fertil. Steril. Section Body Doc Link 16616746 Disease Relevance 0.08 Pain Relevance 0
Western blotting was used for the detection of MIF protein expression, and reverse transcription-polymerase chain reaction (RT-PCR) for MIF mRNA expression.
Positive_regulation (used) of Gene_expression (expression) of MIF mRNA
4) Confidence 0.43 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.78 Pain Relevance 0.25
On the other hand, aspirin and NS398 significantly decreased MIF protein and mRNA expression, and completely blocked bile acid-induced MIF synthesis in the presence or absence of prostaglandin E(2).
Positive_regulation (acid-induced) of Gene_expression (synthesis) of MIF in bile associated with aspirin and bile
5) Confidence 0.43 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.88 Pain Relevance 0.43
Western blotting demonstrated that levels of MIF protein were increased in tumors versus non-malignant tissues, with the expression ratio of MIF over beta-actin of 0.93 +/- 0.21 and 0.57 +/- 0.08, respectively (P = 0.012).
Positive_regulation (increased) of Gene_expression (levels) of MIF protein associated with malignant neoplastic disease and cancer
6) Confidence 0.43 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.93 Pain Relevance 0.36
Western blotting demonstrated that levels of MIF protein were increased in tumors versus non-malignant tissues, with the expression ratio of MIF over beta-actin of 0.93 +/- 0.21 and 0.57 +/- 0.08, respectively (P = 0.012).
Positive_regulation (increased) of Gene_expression (expression) of MIF associated with malignant neoplastic disease and cancer
7) Confidence 0.43 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.94 Pain Relevance 0.40
We think that this group belongs to an initial stage of development of neoplasia, because it presents fewer alterations than the second group, and because the behavior of some genes related with the beginning of tumor development such as genes related with DNA repairment, apoptosis, TNF, Fas-L route, checkpoint, remodeling, and maintenance of extracellular matrix, were underexpressed or lost their expression while other genes were overexpressed, such as human macrophage migration inhibitory factor and some cyclin-dependent kinases and cytoskeletal proteins.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of migration inhibitory factor in macrophage associated with cancer and apoptosis
8) Confidence 0.37 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.19 Pain Relevance 0
We have therefore studied whether serum MIF levels are elevated in patients with AS and whether the levels correlate with oxidative stress markers and disease activity parameters.
Spec (whether) Positive_regulation (elevated) of Spec (whether) Gene_expression (levels) of serum MIF associated with stress, spinal inflammation and disease
9) Confidence 0.32 Published 2010 Journal Mod Rheumatol Section Abstract Doc Link 19787418 Disease Relevance 2.11 Pain Relevance 0.99
The gene expression level of macrophage migration inhibitory factor (MIF) is elevated in CRC tissues, suggesting the use of the protein as a potential biomarker for CRC.
Positive_regulation (elevated) of Gene_expression (expression) of MIF in macrophage associated with colorectal cancer
10) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.74 Pain Relevance 0
In RA, MIF is overexpressed in serum and synovial tissue in correlation with disease activity.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MIF associated with rheumatoid arthritis and disease
11) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.06 Pain Relevance 0.65
However, higher levels of MIF 3 hours after CPB and IL-6 10 hours after CPB were related to the need to use high doses of vasopressors within the first 24 hours after surgery (p = 0.017 and p = 0.05, respectively).
Positive_regulation (after) of Gene_expression (hours) of MIF
12) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.41 Pain Relevance 0.04
However, higher levels of MIF 3 hours after CPB and IL-6 10 hours after CPB were related to the need to use high doses of vasopressors within the first 24 hours after surgery (p = 0.017 and p = 0.05, respectively).
Positive_regulation (levels) of Gene_expression (hours) of MIF
13) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.41 Pain Relevance 0.06
Present data showed that circulating levels of MIF, IL-6, and MCP-1 increased significantly in response to cardiovascular surgery with CPB, and that maximum levels of MIF occurred before those of IL-6 and MCP-1.
Positive_regulation (increased) of Gene_expression (levels) of MIF
14) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.53 Pain Relevance 0.26
Present data showed that circulating levels of MIF, IL-6, and MCP-1 increased significantly in response to cardiovascular surgery with CPB, and that maximum levels of MIF occurred before those of IL-6 and MCP-1.
Positive_regulation (circulating) of Gene_expression (levels) of MIF
15) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.53 Pain Relevance 0.26
However, higher levels of MIF 3 hours after CPB and IL-6 10 hours after CPB were related to the need to use high doses of vasopressors within the first 24 hours after surgery (p = 0.017 and p = 0.05, respectively).
Positive_regulation (after) of Gene_expression (hours) of MIF
16) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1550915 Disease Relevance 0.41 Pain Relevance 0.04
Recently, two reports showed that MIF production was increased during H. pylori infection.14,15 However, to our knowledge, no report in the literature has examined the effect of treatment on MIF levels in H. pylori-infected patients.
Positive_regulation (increased) of Gene_expression (production) of MIF associated with infection
17) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2933123 Disease Relevance 1.04 Pain Relevance 0.17
The serum MIF and TNF-alpha levels of the DPN and DPNP groups were all significantly higher than those of the DM group (P < 0.05 or P < 0.001), while there were not significant differences in the serum MIF and TNF-alpha levels between the DPN and DPNP groups (both P > 0.05).
Positive_regulation (serum) of Gene_expression (levels) of MIF
18) Confidence 0.12 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 19567096 Disease Relevance 0.23 Pain Relevance 0

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