INT121375

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.85
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MIF) cell proliferation (MIF) extracellular space (MIF)
extracellular region (MIF) cytoplasm (MIF)
Anatomy Link Frequency
bile 2
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 99.30 Very High Very High Very High
Bile 15 99.00 Very High Very High Very High
Inflammation 21 94.12 High High
cINOD 3 75.00 Quite High
corticosteroid 2 66.32 Quite High
cytokine 18 54.36 Quite High
Arthritis 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 27 99.40 Very High Very High Very High
INFLAMMATION 22 94.12 High High
Purpura 6 93.84 High High
Disease 4 92.80 High High
Skin Diseases 4 92.04 High High
Malignant Neoplastic Disease 3 89.00 High High
Cancer 7 88.88 High High
Increased Venous Pressure Under Development 3 48.80 Quite Low
Toxicity 1 41.08 Quite Low
Hypertension 1 40.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enzyme-linked immunosorbent assay (ELISA) and RT-PCR were used to detect the expression of the MIF protein and mRNA, respectively, in the supernatant and cultured cells.
Transcription (expression) of MIF protein
1) Confidence 0.62 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.81 Pain Relevance 0.30
On the other hand, aspirin and NS398 significantly decreased MIF protein and mRNA expression, and completely blocked bile acid-induced MIF synthesis in the presence or absence of prostaglandin E(2).
Transcription (expression) of MIF protein in bile associated with aspirin and bile
2) Confidence 0.62 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.89 Pain Relevance 0.43
The aim of this study was to determine the macrophage migration inhibitory factor (MIF) protein and mRNA expression in esophageal squamous cell carcinoma (ESCC), and the effect of bile acids, aspirin and a selective cyclooxygenase-2 (COX-2) inhibitor, NS398, on MIF expression in ESCC cells in vitro.
Transcription (expression) of MIF in bile associated with aspirin, bile and skin cancer
3) Confidence 0.46 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15358635 Disease Relevance 0.59 Pain Relevance 0.24
In the present study, we have demonstrated that KBG treatment significantly suppressed the protein and mRNA levels of MIF, IL-6, IL-8, and TNF-?
Transcription (levels) of MIF
4) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3021874 Disease Relevance 0.55 Pain Relevance 0.13

General Comments

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