INT121379

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Context Info
Confidence 0.66
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.92
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 8
livers 1
thyroid 1
osteoblasts 1
nerve 1
Casr (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 7 99.48 Very High Very High Very High
Bile 98 99.08 Very High Very High Very High
Osteoarthritis 2 99.08 Very High Very High Very High
fibrosis 1 99.04 Very High Very High Very High
agonist 14 98.40 Very High Very High Very High
transcutaneous nerve stimulation 4 98.38 Very High Very High Very High
Paracetamol 9 97.48 Very High Very High Very High
anesthesia 32 82.08 Quite High
Inflammation 23 75.12 Quite High
withdrawal 2 45.44 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 7 99.48 Very High Very High Very High
Osteoarthritis 2 99.08 Very High Very High Very High
Cystic Fibrosis 1 99.04 Very High Very High Very High
Toxicity 5 96.60 Very High Very High Very High
Aging 20 96.32 Very High Very High Very High
Repression 9 94.72 High High
Hypercalcemia 4 91.04 High High
Lifespan 4 87.72 High High
Disease 19 86.24 High High
Hepatotoxicity 9 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAR translocation into the nucleus of PRIP null livers resulted in the induction of CAR target genes such as CYP2B10, necessary for the conversion of acetaminophen to its hepatotoxic intermediate metabolite, N-acetyl-p-benzoquinone imine.
Positive_regulation (induction) of CAR in livers associated with paracetamol
1) Confidence 0.66 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16828057 Disease Relevance 0.08 Pain Relevance 0.18
The increased basal level of CAR and its downstream target genes in GF animals was associated with significant effects on xenobiotic metabolism as assessed by challenge with pentobarbital.
Positive_regulation (increased) of CAR in CAR
2) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.23
In support of this idea, DN1, a fragment of ASC-2 encompassing the first LXXLL motif, suppressed CAR transactivation, and coexpressed ASC-2 but not other LXXLL-type coactivators such as thyroid hormone receptor-associated protein 220 reversed this repression.
Positive_regulation (transactivation) of CAR in thyroid associated with repression
3) Confidence 0.44 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0.39 Pain Relevance 0.25
In this report, we demonstrate that ASC-2 also serves as a coactivator of the xenobiotic nuclear receptor constitutive androstane receptor (CAR).
Positive_regulation (coactivator) of CAR in CAR
4) Confidence 0.44 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15764585 Disease Relevance 0 Pain Relevance 0.05
PURPOSE: To determine whether transcutaneous electrical nerve stimulation (TENS) and focal knee joint cooling will affect the quadriceps central activation ratio (CAR) in patients with tibiofemoral osteoarthritis.
Spec (whether) Positive_regulation (activation) of CAR in nerve associated with transcutaneous nerve stimulation and osteoarthritis
5) Confidence 0.41 Published 2009 Journal Med Sci Sports Exerc Section Abstract Doc Link 19461552 Disease Relevance 0.10 Pain Relevance 0.22
CONCLUSIONS: Both TENS and focal knee joint cooling increased the quadriceps CAR immediately after application in participants with tibiofemoral osteoarthritis.


Positive_regulation (increased) of CAR in CAR
6) Confidence 0.39 Published 2009 Journal Med Sci Sports Exerc Section Body Doc Link 19461552 Disease Relevance 0 Pain Relevance 0
A. 98, 3375-3380), pharmacologic activation of CAR induces multiple LCA detoxifying enzymes and provides strong protection against LCA toxicity.
Positive_regulation (activation) of CAR in CAR associated with toxicity
7) Confidence 0.38 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15358766 Disease Relevance 0.26 Pain Relevance 0.17
This report elegantly provided an explanation as to how an activation of xenobiotic metabolism regulators like CAR and PXR induce Insig-1 by CAR and PXR which may explain the negative effects of some drugs on hepatic lipid levels [14].
Positive_regulation (activation) of CAR in CAR
8) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.13
Our results point to a constitutively higher expression of CAR in the absence of the intestinal microbiota in GF mice, likely because of the elevated levels of the CAR activators bilirubin, bile acids and steroid hormones, the relative contributions of these are so far unknown.
Positive_regulation (elevated) of CAR in CAR associated with bile
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.25
To summarize, the lack of intestinal bacteria in GF mice leads to excess amounts and accumulation of CAR-ligands such as bilirubin, bile acids and steroid hormones.
Positive_regulation (accumulation) of CAR in bile associated with bile
10) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.51 Pain Relevance 0.09
In addition to inhibiting FoxO1 activity, drug-activated SXR and CAR were also shown to inhibit HNF4?
Positive_regulation (activated) of CAR in CAR
11) Confidence 0.12 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.08 Pain Relevance 0
and CAR activation [Sarkar et al., 2007].


Positive_regulation (activation) of CAR in CAR
12) Confidence 0.10 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.25 Pain Relevance 0.06
Loss-of-function variants in the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-sensing receptor (CASR) genes also increase the risk of CP.
Positive_regulation (increase) of calcium-sensing receptor associated with fibrosis, cystic fibrosis and chronic pancreatitis
13) Confidence 0.08 Published 2009 Journal Annu Rev Genomics Hum Genet Section Abstract Doc Link 19453252 Disease Relevance 0.84 Pain Relevance 0.66
It has been demonstrated in vitro that strontium ranelate is an agonist of the CaR and is able to stimulate the replication of osteoblasts through the activation of CaR [36].
Positive_regulation (activation) of CaR in osteoblasts associated with agonist
14) Confidence 0.06 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2744775 Disease Relevance 0.42 Pain Relevance 0.05

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