INT12138

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Context Info
Confidence 0.27
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.71
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) extracellular space (Ins1) extracellular region (Ins1)
transferase activity, transferring acyl groups (Chat) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
cholinergic neurons 1
Ins1 (Rattus norvegicus)
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 8 98.72 Very High Very High Very High
tetrodotoxin 8 97.68 Very High Very High Very High
GABAergic 2 72.80 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 8 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of acetylcholinesterase-positive neurons was not reduced by insulin, suggesting that insulin acts by down-regulating ChAT rather than by killing cholinergic neurons.
insulin Negative_regulation (down-regulating) of ChAT in cholinergic neurons
1) Confidence 0.27 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1629717 Disease Relevance 0.33 Pain Relevance 0.50
Insulin treatment reversibly reduced ChAT activity in cultures plated at densities of greater than 4,000 cells/mm2, and the extent of this reduction increased with increasing cell density.
Insulin Negative_regulation (reduced) of ChAT
2) Confidence 0.23 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1629717 Disease Relevance 0.38 Pain Relevance 0.51

General Comments

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