INT121380

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Context Info
Confidence 0.15
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Casr) oxidoreductase activity (Cyp3a11) endoplasmic reticulum (Cyp3a11)
plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
CAR 2
Casr (Mus musculus)
Cyp3a11 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 3 83.08 Quite High
Paracetamol 1 78.56 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 97.32 Very High Very High Very High
Hepatotoxicity 2 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparison of their responses to LCA treatment demonstrates that CAR predominantly mediates induction of the cytochrome p450 CYP3A11 and the multidrug resistance-associated protein 3 transporter, whereas PXR is the major regulator of the Na+-dependent organic anion transporter 2.
CAR Positive_regulation (mediates) of Positive_regulation (induction) of cytochrome p450 CYP3A11 in CAR
1) Confidence 0.15 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15358766 Disease Relevance 0.25 Pain Relevance 0.18

General Comments

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