INT121399

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.20
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
lung 2
CHO 2
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 4 100.00 Very High Very High Very High
c fibre 4 96.40 Very High Very High Very High
Central nervous system 4 93.96 High High
antagonist 3 87.68 High High
qutenza 8 82.64 Quite High
agonist 3 81.68 Quite High
Neuropeptide 1 70.76 Quite High
antinociception 1 48.68 Quite Low
peptic ulcer disease 1 31.64 Quite Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 83 96.24 Very High Very High Very High
Nicotine Addiction 9 92.88 High High
Sudden Infant Death Syndrome 3 91.16 High High
Sleep Disorders 3 83.68 Quite High
Sprains And Strains 10 80.56 Quite High
Coronary Artery Disease 46 50.00 Quite Low
Asthma 1 49.52 Quite Low
Breast Cancer 2 33.96 Quite Low
Cardiovascular Disease 3 32.72 Quite Low
Disease 8 31.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When CCK was administered during gastric distension, it significantly enhanced NTS Fos expression in response to distension in Cap rats.
Positive_regulation (enhanced) of Gene_expression (expression) of NTS
1) Confidence 0.67 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15905220 Disease Relevance 0 Pain Relevance 0.54
Although all our NTS isolates were susceptible to ciprofloxacin, 19.4% (7 of 36 isolates) and 46.8% (30 of 64 isolates) of the human and livestock NTS isolates were resistant to nalidixic acid (MIC ?
Positive_regulation (resistant) of Gene_expression (isolates) of NTS
2) Confidence 0.41 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.15 Pain Relevance 0
NTS2-induced activation of ERK1/2 was not species-specific, because the same agonistic effects of NT and analogs were observed in CHO cells transfected with the human NTS2 receptor.
Positive_regulation (transfected) of Gene_expression (transfected) of NTS2 in CHO
3) Confidence 0.38 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15361549 Disease Relevance 0 Pain Relevance 0.07
Thus, an upregulation of the substance P system at NTS synapses could contribute to the increased NTS excitability and enhanced reflex responses to lung C-fiber stimulation, providing a potential mechanism to help explain the association of ETS exposure with respiratory symptoms and SIDS.



Positive_regulation (upregulation) of Gene_expression (synapses) of NTS in lung associated with c fibre, nicotine addiction, sudden infant death syndrome and substance p
4) Confidence 0.25 Published 2001 Journal Environ Health Perspect Section Abstract Doc Link PMC1240584 Disease Relevance 0.88 Pain Relevance 0.68
To evaluate the forecast results of ML-kNN comparing with traditional kNN, the following criteria [19] are used:

• Average_Precision evaluates the average fraction of syndrome labels ranked above a particular label which actually is in the label set as follows:

Positive_regulation (results) of Gene_expression (comparing) of kNN associated with syndrome
5) Confidence 0.07 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921356 Disease Relevance 0.16 Pain Relevance 0

General Comments

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