INT1214

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Context Info
Confidence 0.72
First Reported 1976
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 70
Total Number 73
Disease Relevance 29.07
Pain Relevance 16.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
POA 3
joints 2
macrophages 1
PGE 1
CSF 1
PGE (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 37 100.00 Very High Very High Very High
Clonidine 25 99.92 Very High Very High Very High
bradykinin 13 99.86 Very High Very High Very High
antagonist 42 99.72 Very High Very High Very High
diclofenac 7 99.54 Very High Very High Very High
aspirin 31 99.52 Very High Very High Very High
Inflammation 565 99.20 Very High Very High Very High
carpal tunnel syndrome 12 99.04 Very High Very High Very High
agonist 31 99.00 Very High Very High Very High
Neuropathic pain 13 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 633 100.00 Very High Very High Very High
Injury 56 99.72 Very High Very High Very High
Sprains And Strains 19 99.30 Very High Very High Very High
Chronic Renal Insufficiency 1 99.20 Very High Very High Very High
Rhinitis 10 99.12 Very High Very High Very High
Carpal Tunnel Syndrome 14 99.04 Very High Very High Very High
Reprotox - General 1 3 99.02 Very High Very High Very High
Neuropathic Pain 27 98.96 Very High Very High Very High
Colitis 402 98.84 Very High Very High Very High
Inflammatory Bowel Disease 74 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since expression of both Cox-2 and PGE 2 is increased in the intestinal mucosa of patients with UC, as well as in CAC, Cox-2 induced PGE 2 may be a causal player in complex pathways linking chronic inflammation to the development of CAC [22-26].
Gene_expression (expression) of PGE associated with inflammatory bowel disease, inflammation and cancer
1) Confidence 0.72 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.02 Pain Relevance 0.30
In rat paws of acute (carrageenan-induced) and chronic (adjuvant-induced) arthritis models, significant up-regulation of mPGES-1 RNA and protein expression was observed, compared with other PGE synthases, and was also associated with elevated PGE2 levels [9,12,13].
Gene_expression (synthases) of PGE associated with arthritis
2) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174970 Disease Relevance 0.68 Pain Relevance 0.21
TRPV1 is a non-selective cation channel, gated by capsaicin, noxious heat (>45°C), acidic pH (<5.3), and regulated by a variety of inflammatory agents, including protons, bradykinin, ATP, PGE2, 12-lipoxygenase products, protease-activated receptor-2, anandamide, CCL3 and NGF.
Gene_expression (products) of PGE associated with nerve growth factor, inflammation, qutenza and bradykinin
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.80 Pain Relevance 1.29
But we do not know if PGE 2 production is necessary and sufficient to promote tumorigenesis in the absence of TLR4.
Gene_expression (production) of PGE
4) Confidence 0.62 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 1.04 Pain Relevance 0.08
We have previously shown that TLR4-mediated signaling is responsible for mucosal Cox-2 expression and PGE 2 synthesis in the setting of intestinal inflammation [27].
Gene_expression (expression) of PGE associated with inflammation
5) Confidence 0.62 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.97 Pain Relevance 0.25
Recently, enhanced expression of COX-1 and COX-2 mRNA was demonstrated in inflamed muscle tissue from patients with myositis, suggesting a role for them in this disease.13 Three terminal PGE synthases (PGES) catalyse the formation of PGE2 from PGH2 Microsomal PGE synthase 1 (mPGES-1) is strongly induced by proinflammatory stimuli in various cells and preferentially couples with COX-2 contributing to significant PGE2 release.14–16 Cytosolic PGES (cPGES) and mPGES-2 are constitutively expressed and likely to function in the basal production of PGE217 18 Studies of mPGES-1 –/– knock-out mice have demonstrated a critical role for mPGES-1 in the development of pain, fever and inflammation.19 20 mPGES-1 is upregulated in a range of inflammatory diseases and considered a new target for therapeutic strategies to control induced PGE2 synthesis.21–23 However, the expression of mPGES-1 in muscle tissue from patients with myositis has not been studied.
Gene_expression (expressed) of PGE in muscle tissue associated with targeted disruption, pain, inflammation, fever, disease and myositis
6) Confidence 0.58 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 1.35 Pain Relevance 0.34
To investigate the expression of microsomal prostaglandin E (PGE) synthase 1 (mPGES-1) and cyclooxygenase (COX) in muscle biopsies from patients with polymyositis or dermatomyositis before and after conventional immunosuppressive treatment.


Spec (investigate) Gene_expression (expression) of PGE in muscle associated with dermatomyositis and polymyositis
7) Confidence 0.58 Published 2008 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2582339 Disease Relevance 0.58 Pain Relevance 0.03
Expression of PGES and COX
Gene_expression (Expression) of PGE
8) Confidence 0.58 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2582339 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Intravenous infusion of PGE produces analgesia associated with elevation of skin temperature in patients with PHN.


Gene_expression (infusion) of PGE in PGE
9) Confidence 0.58 Published 2010 Journal Pain Med Section Body Doc Link 20345617 Disease Relevance 0.11 Pain Relevance 0
Another group of mice received high dose PGE 2 (200 ?
Gene_expression (received) of PGE
10) Confidence 0.54 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.30 Pain Relevance 0
The mechanism whereby mifepristone provokes enhanced uterine contractility and sensitivity to prostaglandins, with a reduction in abortion times, does not appear to be through endogenous production of PGE or PGF.
Gene_expression (production) of PGE in uterine associated with reprotox - general 1
11) Confidence 0.52 Published 1990 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2198918 Disease Relevance 0.32 Pain Relevance 0.07
RESULTS: PGE(2) was detectable in the first postoperative sample, decreased over the next hour and then increased coincident with the onset of postoperative pain.
Gene_expression (detectable) of PGE
12) Confidence 0.52 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12966473 Disease Relevance 0.16 Pain Relevance 0
We have previously shown that TLR4-mediated signaling is responsible for mucosal Cox-2 expression and PGE 2 synthesis in the setting of intestinal inflammation [27].
Gene_expression (synthesis) of PGE associated with inflammation
13) Confidence 0.48 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.96 Pain Relevance 0.25
We have previously found that TLR4-deficient (TLR4-/-) mice demonstrate decreased expression of mucosal PGE 2 and are protected against colitis-associated neoplasia.
Gene_expression (expression) of PGE associated with colitis and cancer
14) Confidence 0.48 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2912804 Disease Relevance 0.56 Pain Relevance 0
Levels of PGE-M, which had been elevated in four patients prior to therapy, returned to normal.
Gene_expression (Levels) of PGE-M
15) Confidence 0.46 Published 1999 Journal Bone Section Abstract Doc Link 10574582 Disease Relevance 0.99 Pain Relevance 0.68
Interestingly, COX-2 and its metabolite, the presumably proinflammatory PGE(2), are present in the joints during resolution, and blocking COX-2 activity and PGE(2) production within this period perpetuated, instead of attenuated, inflammation.
Gene_expression (production) of PGE in joints associated with inflammation
16) Confidence 0.45 Published 2010 Journal J. Immunol. Section Abstract Doc Link 20435922 Disease Relevance 0.72 Pain Relevance 0.44
Our results demonstrated that paeonol inhibited LPS induced expression of NO, PGE(2) and IL-6.
Gene_expression (expression) of PGE
17) Confidence 0.42 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222121 Disease Relevance 0.42 Pain Relevance 0.46
In Xenopus laevis oocytes, recombinant expressed PGE(2)EP(1) receptors were functional (half maximal effect concentration, 2.09 +/- 0.98 x 10(-6) M).
Gene_expression (expressed) of PGE in oocytes
18) Confidence 0.39 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11524330 Disease Relevance 0.26 Pain Relevance 0.41
PGE2 is produced from arachidonic acid via PGH2 by at least three PGE synthases (PGES), cytosolic PGES (cPGES), and membrane-associated PGES (mPGES)-1 and -2.
Gene_expression (produced) of PGE
19) Confidence 0.39 Published 2004 Journal Neuroreport Section Abstract Doc Link 15194860 Disease Relevance 0.82 Pain Relevance 0.68
Functional coupling of the inducible enzymes COX-2 and mPGES-1 has been proposed for increased production of PGE(2) in different cell types.
Gene_expression (production) of PGE
20) Confidence 0.38 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.45 Pain Relevance 0.18

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