INT121416

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 6
Speculated 11
Reported most in Abstract
Documents 101
Total Number 119
Disease Relevance 52.70
Pain Relevance 47.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
neurons 29
sensory neurons 12
nerve 3
primary sensory neurons 3
intestine 2
Trpm8 (Mus musculus)
Trpm8 - Y745H (5)
Pain Link Frequency Relevance Heat
nociceptor 1233 100.00 Very High Very High Very High
TRP channel 429 100.00 Very High Very High Very High
member 8 20 100.00 Very High Very High Very High
dorsal root ganglion 460 99.84 Very High Very High Very High
agonist 480 99.82 Very High Very High Very High
allodynia 844 99.70 Very High Very High Very High
Analgesic 75 99.64 Very High Very High Very High
Pain 1444 99.56 Very High Very High Very High
Cold hyperalgesia 100 99.56 Very High Very High Very High
qutenza 349 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 641 100.00 Very High Very High Very High
Ganglion Cysts 1564 99.80 Very High Very High Very High
Nervous System Injury 656 99.80 Very High Very High Very High
Neuropathic Pain 1979 99.70 Very High Very High Very High
Hypersensitivity 611 99.68 Very High Very High Very High
Pain 1399 99.56 Very High Very High Very High
Hyperalgesia 574 99.56 Very High Very High Very High
Injury 1536 99.52 Very High Very High Very High
INFLAMMATION 452 99.16 Very High Very High Very High
Targeted Disruption 551 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents.
Gene_expression (expression) of TRPM8 associated with allodynia
1) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.52 Pain Relevance 0.50
An injection of oxaliplatin increased the expression level of TRPM8 mRNA at day 3 after injection and the expression was decreased to the near-normal level on days 10 and 25.
Gene_expression (expression) of TRPM8 mRNA
2) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.46 Pain Relevance 0.53
The expression of TRPM8 mRNA in dorsal root ganglion was determined by the RT-PCR method.
Gene_expression (expression) of TRPM8 mRNA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.52 Pain Relevance 0.47
We show that TRPM8 expression functionally associates with cold sensitivity in cultured DRGs, and provide the first glimpses of the unique anatomical architecture of cold fibers in vivo.
Gene_expression (expression) of TRPM8
4) Confidence 0.78 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18199758 Disease Relevance 0.39 Pain Relevance 0.20
Visualizing cold spots: TRPM8-expressing sensory neurons and their projections.
Gene_expression (expressing) of TRPM8 in sensory neurons associated with qutenza
5) Confidence 0.78 Published 2008 Journal J. Neurosci. Section Title Doc Link 18199758 Disease Relevance 0.57 Pain Relevance 0.36
The anatomical and functional properties of TRPM8-expressing fibers have not been not comprehensively investigated.
Gene_expression (expressing) of TRPM8
6) Confidence 0.78 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18199758 Disease Relevance 0.49 Pain Relevance 0.22
In contrast, neurons activated by lower temperatures have a lower expression of TRPM8 and a prominent I(KD).
Gene_expression (expression) of TRPM8 in neurons
7) Confidence 0.77 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19279249 Disease Relevance 0 Pain Relevance 0.36
Neurons responding to small temperature changes have high functional expression of TRPM8 (transient receptor potential cation channel, subfamily M, member 8) and low expression of I(KD).
Gene_expression (expression) of TRPM8 in Neurons associated with member 8
8) Confidence 0.77 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19279249 Disease Relevance 0 Pain Relevance 0.33
The finding from experiments in genetically modified mice that menthol-induced cold hypersensitivity was not obviously influenced by TRPM8 expression but was dependent on TRPA1 expression was initially surprising.
Gene_expression (expression) of TRPM8 associated with hypersensitivity
9) Confidence 0.77 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.37 Pain Relevance 0.15
Cold-sensitive neurons were present before the expression or functional responses of TRPM8 or TRPA1.
Gene_expression (expression) of TRPM8 in neurons
10) Confidence 0.77 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17344381 Disease Relevance 0.25 Pain Relevance 0.62
RT-PCR analysis revealed the expression of TRPA1 and TRPV1, but not TRPM8, throughout the mouse intestine.
Gene_expression (expression) of TRPM8 in intestine
11) Confidence 0.75 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.57
These results suggest that TRPA1, but not TRPM8, are functionally expressed in the enteric nervous system throughout the mouse intestine on neurons that may also co-express TRPV1, yet the contractile responses to TRPA1 activation differ depending on their location along the intestine.
Neg (not) Gene_expression (expressed) of TRPM8 in intestine
12) Confidence 0.75 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.54
TRPA1, TRPM8, and TRPV1 expressions were examined by reverse transcription-polymerase chain reaction (RT-PCR).
Gene_expression (expressions) of TRPM8
13) Confidence 0.75 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.30
Trpm8, the gene for a cold and menthol receptor, was mostly expressed in small neuronal profiles in naive and operated animals.
Gene_expression (expressed) of Trpm8 in neuronal
14) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.21 Pain Relevance 0.42
For Trpa1 (and Trpm8) we also examined gene expression in the L4DRG.
Spec (examined) Gene_expression (expression) of Trpm8
15) Confidence 0.74 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.12 Pain Relevance 0.35
Expression of both TRPV1 and TRPM8 was demonstrated in the TG [13].
Gene_expression (Expression) of TRPM8
16) Confidence 0.73 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.24 Pain Relevance 0.21
It is plausible that menthol and/or curry odors stimulate the trigeminal nerve system, although the present study found unreduced expression of TRPM8 or early recovery of TRPV1 in the ORNs.
Gene_expression (expression) of TRPM8 in trigeminal nerve associated with fifth nerve
17) Confidence 0.73 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.12 Pain Relevance 0.21
In contrast, expression of TRPM8 was only minimally affected even in the pathological condition, while TRPV1 and TRPV2 showed early recovery after methimazole treatment.



Gene_expression (expression) of TRPM8
18) Confidence 0.73 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.07
The other interesting results were that expression of TRPM8 was not reduced following methimazole treatment.
Gene_expression (expression) of TRPM8
19) Confidence 0.73 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.76 Pain Relevance 0.04
The present study showed that TRPM8 was expressed mainly in the ORNs.
Gene_expression (expressed) of TRPM8
20) Confidence 0.73 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.03

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