INT121419

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.98
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
paw 2
bladder 2
nervous system 2
spinal 1
immune system 1
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 138 100.00 Very High Very High Very High
Endocannabinoid 137 100.00 Very High Very High Very High
Cannabinoid receptor 95 100.00 Very High Very High Very High
Spinal cord 79 99.28 Very High Very High Very High
calcitonin gene related peptide 16 98.24 Very High Very High Very High
Pain 119 97.92 Very High Very High Very High
Multiple sclerosis 10 97.60 Very High Very High Very High
Thalamus 89 97.44 Very High Very High Very High
Dorsal horn 38 97.28 Very High Very High Very High
Perioperative pain 63 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 157 97.92 Very High Very High Very High
Demyelinating Disease 10 97.60 Very High Very High Very High
Post Operative Pain 66 96.68 Very High Very High Very High
Neuropathic Pain 149 96.36 Very High Very High Very High
INFLAMMATION 73 95.52 Very High Very High Very High
Overactive Bladder 50 92.48 High High
Nociception 60 89.56 High High
Urological Neuroanatomy 23 88.76 High High
Hypersensitivity 53 85.16 High High
Nervous System Injury 13 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of the description of supraspinal localization of CB2 receptors and the well-accepted role of structures such as the thalamus (Guilbaud et al., 1990; Bordi & Quartaroli, 2000) contributing to neuropathic states, we hypothesized that supraspinal CB2 receptors in the thalamus might contribute to inhibitory effects of these ligands in neuropathic states; this would have important implications for the future clinical use of this class of compounds.
Localization (localization) of CB2 in thalamus associated with neuropathic pain and thalamus
1) Confidence 0.80 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.51 Pain Relevance 0.47
We have localized cannabinoid receptor 2 protein in rat and mouse somatic sensory nervous system, using an antibody that recognizes mouse cannabinoid receptor 2.
Localization (localized) of cannabinoid receptor 2 protein in nervous system associated with cannabinoid receptor
2) Confidence 0.69 Published 2005 Journal Neuroscience Section Abstract Doc Link 16084654 Disease Relevance 0.21 Pain Relevance 0.45
We first characterized the concentration of ECBs and localization of CB1 and CB2 receptors in the spinal cord following paw incision.
Localization (localization) of CB2 in paw associated with endocannabinoid and spinal cord
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2878341 Disease Relevance 0.84 Pain Relevance 1.14
In order to characterize the targets of the endocannabinoid system following paw incision, we evaluated the relative staining of spinal CB1 and CB2 receptors over time and examined their cellular localization.
Spec (examined) Localization (localization) of CB2 in spinal associated with endocannabinoid
4) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.25 Pain Relevance 0.28
In the current study, we first characterized tissue concentrations of ECBs and the overall expression and cellular localization of CB1 and CB2 receptors in the spinal cord following paw incision.
Localization (localization) of CB2 in paw associated with endocannabinoid and spinal cord
5) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 1.05 Pain Relevance 1.09
In addition, several genes that might modulate the release of eicosanoids, such as BCL6 [20], BTK [21] and CNR2 [22], were also reduced 4 days post-CFA injection.
Localization (release) of CNR2
6) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.23 Pain Relevance 0.16
The localization of CB2 receptor with nerves argues for a role of CB2 in bladder afferent signals which can be best demonstrated by cystometric studies.
Localization (localization) of CB2 in bladder
7) Confidence 0.52 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.22 Pain Relevance 0.21
Co-localization of CB2 receptor antibody stain with the stain for CGRP, TRPV1, and vesicular acetylcholine transporter (VAChT) protein specific for cholinergic nerves further confirmed the expression of CB2 receptor by bladder afferents.
Localization (localization) of CB2 in bladder associated with calcitonin gene related peptide
8) Confidence 0.49 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.22 Pain Relevance 0.17
The endocannabinoid system includes: (1) at least two families of lipid signaling molecules, the N-acyl ethanolamines (e.g., anandamide) and the monoacylglycerols (e.g., 2-arachidonoyl glycerol); (2) multiple enzymes involved in the biosynthesis and degradation of these lipids, including the integral membrane enzyme fatty acid amide hydrolase; and (3) two G-protein coupled receptors, CB1 and CB2, which are primarily localized to the nervous system and immune system, respectively.
Localization (localized) of CB2 in immune system associated with endocannabinoid
9) Confidence 0.34 Published 2004 Journal J. Neurobiol. Section Abstract Doc Link 15362158 Disease Relevance 0.24 Pain Relevance 0.56
The endocannabinoid system includes: (1) at least two families of lipid signaling molecules, the N-acyl ethanolamines (e.g., anandamide) and the monoacylglycerols (e.g., 2-arachidonoyl glycerol); (2) multiple enzymes involved in the biosynthesis and degradation of these lipids, including the integral membrane enzyme fatty acid amide hydrolase; and (3) two G-protein coupled receptors, CB1 and CB2, which are primarily localized to the nervous system and immune system, respectively.
Localization (localized) of CB2 in nervous system associated with endocannabinoid
10) Confidence 0.12 Published 2004 Journal J. Neurobiol. Section Abstract Doc Link 15362158 Disease Relevance 0.24 Pain Relevance 0.56
This might be exploited clinically by using CB1, CB2 or CB1/CB2 agonists, or inhibitors of the membrane transport or catabolism of endocannabinoids that are released in increased amounts, at least in animal models of pain and multiple sclerosis.
Localization (released) of CB2 associated with pain, endocannabinoid, multiple sclerosis and agonist
11) Confidence 0.10 Published 2006 Journal Int J Obes (Lond) Section Abstract Doc Link 16570099 Disease Relevance 0.48 Pain Relevance 1.03
This might be exploited clinically by using CB1, CB2 or CB1/CB2 agonists, or inhibitors of the membrane transport or catabolism of endocannabinoids that are released in increased amounts, at least in animal models of pain and multiple sclerosis.
Localization (released) of CB2 associated with pain, endocannabinoid, multiple sclerosis and agonist
12) Confidence 0.05 Published 2006 Journal Int J Obes (Lond) Section Abstract Doc Link 16570099 Disease Relevance 0.48 Pain Relevance 1.03

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