INT121422

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.24
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BIRC3) intracellular (BIRC3) cytoplasm (BIRC3)
Anatomy Link Frequency
MALT 2
BIRC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 11 99.44 Very High Very High Very High
cytokine 6 86.88 High High
Inflammation 5 78.60 Quite High
COX-2 inhibitor 2 74.64 Quite High
cINOD 4 72.80 Quite High
abdominal pain 3 68.72 Quite High
chemokine 5 45.40 Quite Low
Central nervous system 14 35.72 Quite Low
headache 2 27.28 Quite Low
rheumatoid arthritis 1 20.16 Low Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 180 99.88 Very High Very High Very High
Apoptosis 31 99.42 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 97.40 Very High Very High Very High
Cancer 73 90.96 High High
Pressure And Volume Under Development 2 81.96 Quite High
Genetic Translocation 1 80.76 Quite High
Ascariasis 2 79.48 Quite High
INFLAMMATION 7 78.60 Quite High
Chromosome Aberrations 3 78.40 Quite High
Pathologic Constriction 2 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue.
Gene_expression (Expression) of API2
1) Confidence 0.75 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15363040 Disease Relevance 1.05 Pain Relevance 0.07
Intestinal MALT lymphomas with API2-MALT1 expression have distinctive forms of infiltration compared with those without translocation.
Gene_expression (expression) of API2 in MALT associated with lymphatic system cancer
2) Confidence 0.75 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15363040 Disease Relevance 0.98 Pain Relevance 0.06
3) but remained unknown in the remaining 18 cases. t(14;18)/IGH-BCL2, t(14;18)/IGH-MALT1, and t(1;14)/BCL10-IGH were not detected in any case. t(11;18)/API2-MALT1 was detected in none of the cases, except for one case of DLBCL with MALT lymphoma, which showed positive signals only in MALT lymphoma cells.
Neg (not) Gene_expression (detected) of API2 in MALT associated with lymphatic system cancer and diffuse large b-cell lymphoma
3) Confidence 0.65 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.38 Pain Relevance 0
Finally the activation near the LIP/AIP boundary can be seen at levels ?
Gene_expression (boundary) of AIP
4) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789404 Disease Relevance 0.06 Pain Relevance 0
Aspirin, however, had no effect on expressions of Bcl-2, XIAP, and HIAP-1 in YD-8 cells.
Gene_expression (expressions) of HIAP-1 associated with aspirin
5) Confidence 0.40 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.63
portion of API2, an inhibitor of apoptosis located at 11q21 leading to production of API2-MALT1 fusion transcript [22].
Gene_expression (production) of API2 associated with apoptosis
6) Confidence 0.16 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 1.14 Pain Relevance 0.04
Akt also blocks cytochrome C release from the mitochondria through the regulation of Bcl-2 [31] and regulates expression of cIAP-1 [32].
Gene_expression (expression) of cIAP-1
7) Confidence 0.11 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 1.00 Pain Relevance 0.16

General Comments

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