INT121457

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2004
Negated 0
Speculated 1
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.91
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KNG1, Trpv1) cytosol (Trpv1) extracellular space (KNG1)
extracellular region (KNG1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
dorsal root ganglion 1
afferent neurons 1
KNG1 (Homo sapiens)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 8 100.00 Very High Very High Very High
Inflammation 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
qutenza 2 99.66 Very High Very High Very High
Nerve growth factor 2 97.52 Very High Very High Very High
dorsal root ganglion 2 96.32 Very High Very High Very High
Inflammatory mediators 2 95.76 Very High Very High Very High
Hyperalgesia 2 93.44 High High
b2 receptor 4 77.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Ganglion Cysts 2 95.84 Very High Very High Very High
Hyperalgesia 2 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we investigated whether bradykinin, which is a pain-producing inflammatory mediator, sensitizes vanilloid receptor 1 by inducing the activation of cyclooxygenases, phospholipase C and phospholipase A2 in rat dorsal root ganglion cells.
bradykinin Spec (whether) Positive_regulation (sensitizes) of vanilloid receptor 1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, pain, inflammation and bradykinin
1) Confidence 0.16 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363973 Disease Relevance 0.48 Pain Relevance 0.64
Sensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neurons.
bradykinin Positive_regulation (induced) of vanilloid receptor 1 in afferent neurons associated with qutenza and bradykinin
2) Confidence 0.15 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15363973 Disease Relevance 0.43 Pain Relevance 0.69

General Comments

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