INT121464

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprm1, Dnm2) signal transduction (Oprm1) cytoskeleton (Dnm2)
nucleus (Dnm2) GTPase activity (Dnm2) protein complex (Dnm2)
Oprm1 (Mus musculus)
Dnm2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 14 100.00 Very High Very High Very High
MU agonist 3 96.40 Very High Very High Very High
antagonist 6 94.88 High High
mu opioid receptor 3 94.32 High High
Opioid 2 91.52 High High
Morphine 2 86.72 High High
agonist 3 86.08 High High
Immobilon 5 84.32 Quite High
Spinal cord 2 77.36 Quite High
narcan 3 65.28 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mu-opioid receptor up-regulation has been associated with decreases in the trafficking protein dynamin-2, whereas mu-opioid receptor down-regulation produces an increase in dynamin-2 abundance.
Negative_regulation (down-regulation) of mu-opioid receptor Positive_regulation (increase) of dynamin-2 associated with opioid receptor
1) Confidence 0.34 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.26

General Comments

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