INT121469

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2004
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde3a) signal transduction (Pde3a)
Pde3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 80 90.72 High High
dexamethasone 24 60.24 Quite High
cytokine 16 42.32 Quite Low
chemokine 2 41.20 Quite Low
Potency 4 26.80 Quite Low
anesthesia 1 25.00 Low Low
Inflammatory mediators 2 14.40 Low Low
Restless leg syndrome 2 7.04 Low Low
Disease Link Frequency Relevance Heat
Disease 10 93.92 High High
INFLAMMATION 82 90.72 High High
Adhesions 2 74.72 Quite High
Asthma 26 74.52 Quite High
Pulmonary Disease 2 59.12 Quite High
Cardiovascular Disease 2 55.36 Quite High
Reprotox - General 2 4 53.20 Quite High
Increased Venous Pressure Under Development 2 7.04 Low Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore conclude that PDE3 inhibition by milrinone augments insulin secretion in vivo in mice after oral but not after intravenous glucose, which may be explained by enhanced response to the cAMP-dependent insulinotropic action of endogenously released GLP-1.
PDE3 Neg (inhibition) Binding (inhibition) of
1) Confidence 0.23 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15364011 Disease Relevance 0 Pain Relevance 0
Our study used a combination of separate PDE 3 and PDE 4 inhibitor and not a dual/mixed compound which posses both PDE 3 and PDE 4 inhibitory potential.
PDE 3 Neg (not) Binding (combination) of
2) Confidence 0.18 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.96 Pain Relevance 0.29
To date, however, very little is known regarding the potential interaction between selective inhibitors of PDE 3, PDE 4 and PDE 5.
PDE 3 Binding (interaction) of
3) Confidence 0.18 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.46 Pain Relevance 0.15

General Comments

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