INT12148

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 3.13
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGKV1-5)
Anatomy Link Frequency
neuronal 2
neurons 2
cortex 2
radial 1
radius 1
IGKV1-5 (Homo sapiens)
Pain Link Frequency Relevance Heat
glial activation 4 100.00 Very High Very High Very High
medulla 11 99.36 Very High Very High Very High
magnetoencephalography 51 96.34 Very High Very High Very High
addiction 15 94.24 High High
Central nervous system 44 89.64 High High
Deafferentation 8 87.28 High High
Inflammation 6 86.76 High High
imagery 17 82.48 Quite High
cytokine 2 77.44 Quite High
Transcranial magnetic stimulation 36 71.24 Quite High
Disease Link Frequency Relevance Heat
Optic Nerve Injuries 70 99.84 Very High Very High Very High
Ocular Hypertension 142 98.48 Very High Very High Very High
Hypertension 12 96.92 Very High Very High Very High
Death 6 95.56 Very High Very High Very High
INFLAMMATION 6 86.76 High High
Heart Rate Under Development 2 83.20 Quite High
Nociception 6 79.04 Quite High
Disease 8 73.44 Quite High
Cognitive Disorder 27 73.28 Quite High
Injury 27 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies reported an increase in V1 activity to global form [50]–[52], while others still reported a decrease in activity [53], [54].
Positive_regulation (increase) of V1
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0
Eighty percent of the sites recorded in the retinotopically corresponding region of MT during inactivation of V1 were found to be visually responsive.
Positive_regulation (inactivation) of V1
2) Confidence 0.50 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0
It was found that, during inactivation of V1, the preferred direction changed for most neurons but remained close to the preferred direction or to its opposite in the control situation.
Positive_regulation (inactivation) of V1 in neurons
3) Confidence 0.50 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0
During inactivation of V1, the average tuning curve of neurons became broader mostly because of strong reductions in the response to directions close to the preferred and nonpreferred.
Positive_regulation (inactivation) of V1 in neurons
4) Confidence 0.44 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0.09
Glass patterns were viewed eccentrically in an attempt to confine any V1 activity to one quadrant of retinotopic cortex, thereby minimizing the occurrence of self-cancelling magnetic fields that may arise because of the cruciform architecture of primary visual areas.
Positive_regulation (confine) of V1 in cortex
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0
We conclude: (i) visual area V3a is involved in the analysis of global form; (ii) the neural signature for perception of structure, as assessed using MEG, is a reduction in 10–20 Hz oscillatory power; (iii) different neural processes may underlie the perception of horizontal as opposed to radial or rotational structure; and (iv) area V1 is not strongly activated by global form in Glass patterns.



Neg (not) Positive_regulation (activated) of V1 in radial associated with magnetoencephalography
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0.05
Contralateral brainstem activity is more pronounced by stimulation of V1 as compared to V3.
Positive_regulation (stimulation) of V1 in brainstem associated with medulla
7) Confidence 0.35 Published 2010 Journal J. Neurol. Section Abstract Doc Link 19756824 Disease Relevance 0.18 Pain Relevance 0.23
Contralateral activation was more frequent during stimulation of the V1 than of the V3 region.
Positive_regulation (stimulation) of V1
8) Confidence 0.35 Published 2010 Journal J. Neurol. Section Abstract Doc Link 19756824 Disease Relevance 0.22 Pain Relevance 0.23
As expected, strong activation of non-lesioned parts of V1 was preserved throughout the course of our experiments, whereas inside the lesioned V1 area coherence remained consistently at noise levels (?
Positive_regulation (activation) of V1
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Moreover, there is evidence from EBS studies in animals that the electrical stimulation of V1 produces a change of activity in neural structures that are known to be connected with the V1 (e.g., areas V2, V3, and MT) (Tolias et al., 2005).
Positive_regulation (stimulation) of V1 in neural
10) Confidence 0.25 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2889679 Disease Relevance 0.07 Pain Relevance 0
As expected, prior to lesioning the entire central sectors of areas V1, V2, and V3 were strongly activated by the retinotopic stimulus.
Positive_regulation (activated) of V1
11) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Although our data strongly argue that areas V2 and V3 are capable of contributing to V1 independent visual processing, the specific pathways that mediate the V1-independent responses in these areas remain unclear.
Positive_regulation (mediate) of V1
12) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Flow of visual information in the absence of V1
Positive_regulation (absence) of V1
13) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
During the pre-lesion experiments visual stimulation with an expanding ring paradigm resulted in strong and reliable activation of the entire visual cortex (areas V1, V2, V3, V4, V5/MT) with single voxel coherence levels >0.7 and z-scores usually reaching values of >15 (Figure 2A).
Positive_regulation (activation) of V1 in cortex
14) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0.06 Pain Relevance 0
The extent of the V1 lesion (Figure S1) and its effect on the activation of the LPZs in areas V2, V3 and on the activation of the non-lesioned part of V1 was assessed in each subsequent experiment, starting one month post lesion.
Positive_regulation (activation) of V1
15) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Thompson et al. [27] demonstrated a double dissociation for coherent motion perception following rTMS stimulation of V1 and V5/MT, suggesting competing percepts from different visual areas.
Positive_regulation (stimulation) of V1
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.03
Thus to the extent that rTMS influences neuronal activity, we might expect the accuracy or speed of decisions about stimulus orientation to be affected by stimulation of V1.
Positive_regulation (stimulation) of V1 in neuronal
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860988 Disease Relevance 0 Pain Relevance 0.04
We conclude that the increase in V1 and alpha pressor activities contributes to the subtotal nephrectomy-saline hypertension and the augmentation of alpha pressor activity by vasopressin may participate in this contribution.
Positive_regulation (increase) of V1 associated with hypertension
18) Confidence 0.06 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10789696 Disease Relevance 0.76 Pain Relevance 0.09
Another possibility is that the LFP reflects not only activity generated within V1 but also the synaptic activity of reentrant inputs from higher visual areas.


Positive_regulation (generated) of V1
19) Confidence 0.06 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
This test also confirmed that GFAP and MAC-1 positive cells were from separate populations in V1 of ONT brains (p<0.05; Figure 6A).


Positive_regulation (populations) of V1 in brains associated with optic nerve injuries
20) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.75 Pain Relevance 0

General Comments

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