INT121480

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 4.51
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
hip 9
spine 1
neurons 1
amygdala 1
knee 1
St13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 38 100.00 Very High Very High Very High
amygdala 3 99.76 Very High Very High Very High
Dopamine 10 99.32 Very High Very High Very High
Spinal cord 11 96.40 Very High Very High Very High
tetrodotoxin 2 91.68 High High
Neurotransmitter 2 90.44 High High
GABAergic 3 85.16 High High
spinal dorsal horn 17 76.96 Quite High
alcohol 13 76.72 Quite High
Osteoarthritis 12 73.32 Quite High
Disease Link Frequency Relevance Heat
Frailty 497 100.00 Very High Very High Very High
Hip Fractures 158 96.16 Very High Very High Very High
Endometriosis (extended) 9 90.64 High High
Hypercalcemia 24 83.76 Quite High
Body Weight 10 82.16 Quite High
Nicotine Addiction 13 78.48 Quite High
Cognitive Disorder 4 78.16 Quite High
Nociception 4 72.16 Quite High
Schizophrenia 2 70.16 Quite High
Aging 10 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the epidemiological data from Scandinavia indicates that although early studies (dating to the1950s) described an increase in hip fracture incidence, the rates appear to have fallen in the most recent periods.
Positive_regulation (increase) of hip in hip associated with frailty
1) Confidence 0.50 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.43 Pain Relevance 0
Studies from Malmo, Sweden, showed an exponential increase in hip fracture incidence from 1950 to 1985 in both men and women over age 50, increasing from an annual age-adjusted incidence of 150–390/100 000 in men and 300–830/100 000 in women.28 Increases were seen for both trochanteric and cervical fractures.
Positive_regulation (increase) of hip in hip associated with frailty
2) Confidence 0.36 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.58 Pain Relevance 0
A study by Koh et al. revealed that hip fracture rates from 1991 to 1998 (per 100 000) were 152 in men and 402 in women; this was respectively 1.5 and 5 times higher than corresponding rates in 1960s.5 Examined by ethnicity, since 1960, the main increase in hip fracture rates has been seen in Chinese and Malays, while the rates in the Indian ethnic group appear to have decreased.
Positive_regulation (increase) of hip in hip associated with frailty
3) Confidence 0.34 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.83 Pain Relevance 0.04
Another study from the US used the national hospital discharge survey (which covers 0.6% of all patient discharges) to analyze secular trends in the white population from 1970 to 1983.19 An overall increase of 9.3% in age- and sex-adjusted hip fracture incidence rates was observed over the 14-year period.
Spec (analyze) Positive_regulation (increase) of hip in hip associated with frailty
4) Confidence 0.34 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.49 Pain Relevance 0
Another study from Spain looked at hip fracture trends in northern Spain between 1988 and 2002 using clinical records from all hospitals in the region of Cantabria.44 Whilst the crude hip fracture incidence increased during this period, no significant changes were noticed following adjustment for age.
Positive_regulation (increased) of hip in hip associated with frailty
5) Confidence 0.34 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.67 Pain Relevance 0
Revision rates after hip resurfacing were increased especially in women.
Positive_regulation (increased) of hip in hip
6) Confidence 0.16 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2528048 Disease Relevance 0.06 Pain Relevance 0
The highest rates after hip replacement were seen in patients who had undergone hip resurfacing and the highest rates after knee replacement in patients who had a unicondylar prosthesis.
Positive_regulation (undergone) of hip in knee
7) Confidence 0.16 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2528048 Disease Relevance 0.16 Pain Relevance 0
Post hip replacement, the highest revision rate was in patients who had undergone hip resurfacing, especially women.
Positive_regulation (undergone) of hip in hip
8) Confidence 0.16 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2528048 Disease Relevance 0.17 Pain Relevance 0.04
Haloperidol produced a slight increase in ACh release in the vHIP at 1 mg/kg, and DA release in the mPFC at 0.1 mg/kg.
Positive_regulation (increase) of vHIP associated with dopamine
9) Confidence 0.13 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.33 Pain Relevance 0.74
In hippocampal (HIP) neurons, GlyRs are thought to be primarily the homopentamer of ?
Positive_regulation (neurons) of HIP in neurons
10) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.14 Pain Relevance 0.42
The region-specific mRNA expression of TRPC4 and 5 mRNA throughout the brain was concentrated in areas of the corticolimbic system, such as the PFC, orbitofrontal cortex, LS, HIP, and amygdala.
Positive_regulation (concentrated) of HIP in amygdala associated with hippocampus and amygdala
11) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.17
After 1 year, ibandronate therapy produced significant and dose-dependent increases in lumbar spine and hip BMD and decreases in biochemical markers of bone turnover.
Positive_regulation (increases) of hip in hip
12) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684081 Disease Relevance 0.22 Pain Relevance 0
Similarly, total hip BMD increased by 2.2%, 2.9%, and 0.6%, in the corresponding groups, respectively.
Positive_regulation (increased) of hip in hip
13) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684081 Disease Relevance 0.22 Pain Relevance 0
After 1 year, ibandronate therapy produced significant and dose-dependent increases in lumbar spine and hip BMD and decreases in biochemical markers of bone turnover.
Positive_regulation (increases) of hip in spine
14) Confidence 0.01 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684081 Disease Relevance 0.22 Pain Relevance 0

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