INT121481

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.70
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
hip 2
superior 1
St13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 20 99.98 Very High Very High Very High
Hippocampus 6 97.20 Very High Very High Very High
Neurotransmitter 4 96.84 Very High Very High Very High
alcohol 3 91.60 High High
tetrodotoxin 2 86.28 High High
antagonist 2 65.00 Quite High
Nucleus accumbens 2 58.72 Quite High
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 105 100.00 Very High Very High Very High
Disease 3 100.00 Very High Very High Very High
Lifespan 2 98.04 Very High Very High Very High
Schizophrenia 4 97.58 Very High Very High Very High
Cognitive Disorder 8 97.24 Very High Very High Very High
Aging 2 94.92 High High
Nicotine Addiction 3 89.92 High High
Obesity 1 87.84 High High
Osteoporosis 7 73.04 Quite High
Hip Fractures 31 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic factors may play an important role in the etiology of hip fracture, as also environmental factors.
Localization (etiology) of hip in hip associated with frailty
1) Confidence 0.54 Published 2011 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC3004072 Disease Relevance 0.92 Pain Relevance 0.05
The National Institute for Health and Clinical Excellence (NICE) recommended in 2002 that hip resurfacing should be considered as an option for patients with advanced hip disease who are likely to live longer than the expected lifespan of a conventional joint prosthesis [30].
Localization (disease) of hip in hip associated with lifespan and disease
2) Confidence 0.26 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2528048 Disease Relevance 0.29 Pain Relevance 0
These differences may contribute, at least in part, to the superior ability of clozapine, compared to haloperidol, to improve cognition in schizophrenia. 5-HT(1A) agonism is important to the ability of clozapine and perhaps other atypical APDs to increase DA, but not ACh, release in the vHIP, as well as the mPFC.
Localization (release) of vHIP in superior associated with cognitive disorder, dopamine and schizophrenia
3) Confidence 0.19 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.25 Pain Relevance 0.53
In conclusion, clozapine increases ACh and DA release in the vHIP and mPFC, whereas haloperidol has minimal effects on the release of these two neurotransmitters in either region.
Localization (release) of vHIP associated with neurotransmitter and dopamine
4) Confidence 0.19 Published 2004 Journal Brain Res. Section Abstract Doc Link 15364019 Disease Relevance 0.23 Pain Relevance 0.72

General Comments

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