INT121493

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 55
Total Number 62
Disease Relevance 73.43
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
skin 3
epithelium 2
macrophages 1
nephron 1
Tongue 1
XRCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 125 99.80 Very High Very High Very High
Crohn's disease 9 97.28 Very High Very High Very High
backache 14 97.20 Very High Very High Very High
Angina 10 93.24 High High
Central nervous system 28 93.12 High High
cva 33 92.16 High High
Pain 88 90.12 High High
COX-2 inhibitor 48 85.60 High High
metalloproteinase 11 85.04 High High
Analgesic 17 82.76 Quite High
Disease Link Frequency Relevance Heat
Renal Cancer 2598 100.00 Very High Very High Very High
Cancer 2021 100.00 Very High Very High Very High
Disease 684 100.00 Very High Very High Very High
Carcinoma 532 100.00 Very High Very High Very High
Renal Cell Carcinoma 113 100.00 Very High Very High Very High
Pheochromocytoma 44 100.00 Very High Very High Very High
Metastasis 616 99.70 Very High Very High Very High
Recurrence 99 99.68 Very High Very High Very High
Fever 18 99.64 Very High Very High Very High
Nicotine Addiction 50 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report a case of a young man who developed an aggressive Xp11 translocation RCC.
Gene_expression (aggressive) of RCC associated with renal cancer
1) Confidence 0.65 Published 2009 Journal Int. J. Urol. Section Abstract Doc Link 19298350 Disease Relevance 0.97 Pain Relevance 0.10
METHODS AND RESULTS: We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P53, PCNA, TERT, and XRCC1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation (ACS).
Spec (analyzed) Gene_expression (expression) of XRCC1 in plaques
2) Confidence 0.62 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.19 Pain Relevance 0
Caregivers were asked about the impact of these symptoms on the RCC patient's daily life, to describe the physical and emotional symptoms that bothered the RCC patient the most before and after treatment, and the changes that they noticed in signs, symptoms, and functioning once treatment began.


Gene_expression (patient) of RCC associated with renal cancer
3) Confidence 0.51 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1929060 Disease Relevance 0.63 Pain Relevance 0
While these questionnaires were designed to assess HRQL among cancer patients, these measures are not specific to RCC or kidney cancer overall.
Gene_expression (overall) of RCC in kidney associated with cancer and renal cancer
4) Confidence 0.51 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1929060 Disease Relevance 1.54 Pain Relevance 0
Tongue metastasis as an initial presentation of RCC is extremely rare and we found only three cases published in the literature so far, reported in 1987, 1994 and 1996 (Table 2).
Gene_expression (presentation) of RCC in Tongue associated with renal cancer and metastasis
5) Confidence 0.40 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2495001 Disease Relevance 1.51 Pain Relevance 0.10
It is known that RCC has a 1–5% recurrence
Gene_expression (has) of RCC associated with renal cancer and recurrence
6) Confidence 0.39 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2467459 Disease Relevance 1.11 Pain Relevance 0
The expression product of XRCC1 is essential in repairing DNA defects caused by ionizing radiation and alkylating agents.
Gene_expression (expression) of XRCC1
7) Confidence 0.39 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.07 Pain Relevance 0
Most

of the cases of RCC are sporadic; however there are some defined types of RCC

Gene_expression (types) of RCC associated with renal cancer
8) Confidence 0.39 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.45 Pain Relevance 0.49
But

smoking is not only important in the genesis of RCC, and prognostic nomograms

Gene_expression (genesis) of RCC associated with nicotine addiction and renal cancer
9) Confidence 0.39 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.32 Pain Relevance 0
It has been reported that the coding regions of the ATM gene has a reduced nucleotide diversity in human and chimpanzee as compared to other genes such as ABCB1, BRCA1/2, PTGS2 and XRCC1, in particular the last 2650 bp of gene containing among other the PI3K domain [26].
Gene_expression (/) of XRCC1
10) Confidence 0.38 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 0.56 Pain Relevance 0
The lesion was treated without biopsy, because the MRI features suggested metastatic RCC.
Gene_expression (suggested) of RCC associated with renal cancer and imagery
11) Confidence 0.37 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976113 Disease Relevance 1.68 Pain Relevance 0.10
also important to state that RCC is found incidentally in 1.5% of the autopsies [13].


Gene_expression (found) of RCC associated with renal cancer
12) Confidence 0.35 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.07 Pain Relevance 0
to sixty percent of the patients with VHL disease present an RCC.
Gene_expression (present) of RCC associated with renal cancer and disease
13) Confidence 0.35 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.99 Pain Relevance 0.09
Our study also found that As exposure has a profound negative impact on DNA repair, decreasing positive expression for XRCC1, MGMT, and hMSH2 mRNA with the increasing severity of skin lesion in arsenicosis patients (Table 3).
Gene_expression (expression) of XRCC1 in skin
14) Confidence 0.34 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.12 Pain Relevance 0
Cells with XRCC1 deletion were found to be sensitive to ionization radiation and had a high SCE ratio (Zheng 1999).
Gene_expression (deletion) of XRCC1
15) Confidence 0.34 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.12 Pain Relevance 0
In the current case, metastatic RCC to the skeletal muscle was found by chance during a regular checkup for metastasis using CT on the abdominal cavity.
Gene_expression (found) of RCC in cavity associated with renal cancer and metastasis
16) Confidence 0.33 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976113 Disease Relevance 1.51 Pain Relevance 0.16
In addition to these eleven genes, 83 others were identified by Lenburg et al. as differentially expressed in RCC.
Gene_expression (expressed) of RCC associated with renal cancer
17) Confidence 0.27 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.08 Pain Relevance 0.03
Genes that have been identified as having noteworthy differential gene expression in four or more RCC studies (Young et al. 2001; Boer et al. 2001; Takahashi et al. 2001; Gieseg et al. 2002; Lenburg et al. 2003) are indicated with **.
Gene_expression (expression) of RCC associated with renal cancer
18) Confidence 0.27 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.99 Pain Relevance 0
Expressions of O-6-methylguanine DNA methyltransferase (MGMT), X-ray repair complementing defective repair in Chinese hamster cells 1(XRCC1), and mismatch repair gene (hMSH2) mRNA (Table 3) were analyzed by in situ hybridization in 61 skin tissue samples.
Spec (analyzed) Gene_expression (Expressions) of XRCC1 in skin
19) Confidence 0.26 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0 Pain Relevance 0
In other manuscript, incidental RCC
Gene_expression (incidental) of RCC associated with carcinoma
20) Confidence 0.22 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.44 Pain Relevance 0

General Comments

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