INT121494

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 64
Total Number 65
Disease Relevance 10.03
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
mononuclear cells 3
colon 2
somatic cells 1
liver 1
finger 1
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2632 99.84 Very High Very High Very High
Inflammation 108 99.60 Very High Very High Very High
agonist 224 99.00 Very High Very High Very High
Central nervous system 56 95.36 Very High Very High Very High
cINOD 61 76.60 Quite High
Angina 1 50.00 Quite Low
COX2 10 10.00 Low Low
aspirin 5 10.00 Low Low
cytokine 54 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 224 100.00 Very High Very High Very High
INFLAMMATION 180 99.60 Very High Very High Very High
Cancer 958 98.36 Very High Very High Very High
Hepatitis 74 96.76 Very High Very High Very High
Disorder Of Lipid Metabolism 56 96.56 Very High Very High Very High
Papillomavirus Infection 56 96.20 Very High Very High Very High
Targeted Disruption 114 96.08 Very High Very High Very High
Cervical Cancer 56 94.80 High High
Aging 232 89.92 High High
Reprotox - General 1 112 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression analysis showed that the proapoptotic genes (ie, BAX, CASP1, FAS, FAS L, FOS, NFkB2, P53, PCNA) were significantly more expressed (P<0.001) in ACS plaques, whereas the antiapoptotic genes (ie, MDM2, TERT, XRCC1) were more transcribed (P<0.001) in stable angina plaques.
Transcription (transcribed) of TERT in plaques
1) Confidence 0.69 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.12 Pain Relevance 0
CONCLUSION: NSAIDs inhibit telomerase activity at hTERT transcriptional, mRNA, and protein levels in colon carcinoma cells.
Transcription (transcriptional) of telomerase in colon
2) Confidence 0.52 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.05 Pain Relevance 0
CONCLUSION: NSAIDs inhibit telomerase activity at hTERT transcriptional, mRNA, and protein levels in colon carcinoma cells.
Transcription (transcriptional) of hTERT in colon
3) Confidence 0.52 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.05 Pain Relevance 0
, a profibrogenic growth factor released during liver inflammation, rapidly represses TERT transcription in normal and neoplastic cells on a mechanism depending on the intracellular signaling protein Smad3 [40].
Transcription (transcription) of TERT in liver associated with inflammation
4) Confidence 0.45 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.58 Pain Relevance 0.05
NSAIDs inhibited hTERT mRNA and protein expression through suppression of hTERT transcriptional activity.
Transcription (expression) of hTERT
5) Confidence 0.39 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.06 Pain Relevance 0
Expression of hTERT mRNA and protein was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively.
Transcription (Expression) of hTERT
6) Confidence 0.39 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.08 Pain Relevance 0
Expression of hTERT mRNA and protein was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively.
Transcription (detected) of hTERT
7) Confidence 0.39 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.08 Pain Relevance 0
silencing on hTERT gene transcription. hTERT mRNA expression was found to increase in PPAR?
Transcription (transcription) of hTERT
8) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.20
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Transcription (transcription) of hTERT associated with kinase c
9) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0.48
and hTERT transcription observed in this study suggests that PPAR?
Transcription (transcription) of hTERT
10) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0
in the regulation of the transcription of c-myc and hTERT genes.
Transcription (transcription) of hTERT
11) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.16 Pain Relevance 0.12
In order to determine whether or not c-myc mediates the Receptor Ck dependent down-regulation of hTERT gene transcription, normal human PBMCs cultured in medium containing 10% NHS were exposed to antibody against Receptor Ck along with 1 ?
Transcription (transcription) of hTERT
12) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
In order to assess the involvement of PKC in the Receptor Ck dependent regulation of the transcription of hTERT, c-myc and PPAR?
Transcription (transcription) of hTERT associated with kinase c
13) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0.29
and hTERT gene transcription, we used PPAR?
Transcription (transcription) of hTERT
14) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.18 Pain Relevance 0.12
However, the role of PKC in the transcription of hTERT gene has not been thoroughly investigated.
Transcription (transcription) of hTERT associated with kinase c
15) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.20 Pain Relevance 0.50
activation and hTERT gene transcription.
Transcription (transcription) of hTERT
16) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0.33
Hence, it was inferred that cyclin D and Bcl-2 might not play any role in the regulation of hTERT transcription in normal human PBMCs.


Transcription (transcription) of hTERT
17) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Transcription (transcription) of hTERT associated with kinase c
18) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0.47
Role of c-myc in Receptor Ck dependent regulation of hTERT gene transcription
Transcription (transcription) of hTERT
19) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Transcription (transcription) of hTERT in somatic cells associated with repression
20) Confidence 0.29 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.20

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