INT121495

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.11
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (XRCC1) nucleus (XRCC1) intracellular (XRCC1)
Anatomy Link Frequency
plaques 1
XRCC1 (Homo sapiens)
XRCC1 - R280H (1)
Pain Link Frequency Relevance Heat
alcohol 4 85.64 High High
palliative 1 51.44 Quite High
Angina 2 50.00 Quite Low
Pain 33 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 281 100.00 Very High Very High Very High
Carcinoma 78 100.00 Very High Very High Very High
Nasopharynx Cancer 103 99.24 Very High Very High Very High
Cancer 197 99.16 Very High Very High Very High
Metastasis 39 93.48 High High
Disease 77 92.88 High High
Nicotine Addiction 13 92.20 High High
Malignant Neoplastic Disease 18 89.44 High High
Hypoxia 6 78.20 Quite High
Obesity 13 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
was observed with polymorphism of the XRCC1 gene (Arg280His), polymorphism of
Transcription (polymorphism) of XRCC1 (R280H)
1) Confidence 0.49 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.77 Pain Relevance 0
Gene expression analysis showed that the proapoptotic genes (ie, BAX, CASP1, FAS, FAS L, FOS, NFkB2, P53, PCNA) were significantly more expressed (P<0.001) in ACS plaques, whereas the antiapoptotic genes (ie, MDM2, TERT, XRCC1) were more transcribed (P<0.001) in stable angina plaques.
Transcription (transcribed) of XRCC1 in plaques
2) Confidence 0.43 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.12 Pain Relevance 0
Three researchers independently reviewed the interview transcripts of RCC patients and caretakers to identify and summarize key themes, recurrent words, and specific health issues.
Transcription (transcripts) of RCC associated with renal cancer
3) Confidence 0.40 Published 2007 Journal Health Qual Life Outcomes Section Body Doc Link PMC1929060 Disease Relevance 0.62 Pain Relevance 0
study, an increased risk of RCC was found only among women with regular coffee
Transcription (risk) of RCC associated with renal cancer
4) Confidence 0.40 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.07 Pain Relevance 0.04
In this case the low positive rate of XRCC1 mRNA in the carcinoma group (27%) was significantly lower than that for the common pathological changes group (77%; p < 0.01).
Transcription (rate) of XRCC1 associated with carcinoma
5) Confidence 0.27 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.35 Pain Relevance 0
In other manuscript, incidental RCC
Transcription (manuscript) of RCC associated with carcinoma
6) Confidence 0.23 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2629071 Disease Relevance 1.45 Pain Relevance 0
Historical management options in RCC
Transcription (options) of RCC associated with renal cancer
7) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 1.73 Pain Relevance 0.05

General Comments

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