INT121496
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Up-regulated human telomerase reverse transcriptase expression was detectable and increased gradually with cancer development and was primarily observed at the borderline IPMN stage and then in more advanced histopathologies. | |||||||||||||||
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Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas. | |||||||||||||||
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We analyzed telomerase expression in 68 IPMN samples and assessed telomere length by quantitative fluorescence in situ hybridization in samples taken from 17 sequential IPMN patients that included 37 individual loci. | |||||||||||||||
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Lymphocytes and hyperplastic epithelial cells isolated from tissues with the histologic appearance of pancreatitis showed various expression levels of hTERT. | |||||||||||||||
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There were significant differences in hTERT expression among carcinoma cells, IPMN cells, and normal ductal cells isolated from pancreatic tissues by microdissection. | |||||||||||||||
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We found significant differences in hTERT expression among carcinoma-derived, intraductal papillary mucinous neoplasm (IPMN)-derived, and chronic pancreatitis-derived juice samples. | |||||||||||||||
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METHODS AND RESULTS: We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P53, PCNA, TERT, and XRCC1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation (ACS). | |||||||||||||||
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The observations in these families suggest that the penetrance of the TERT mutation is incomplete, though substantial (? | |||||||||||||||
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This is consistent with a recent report of a wide spectrum of familial liver disease in kindreds with telomerase mutations, including two TERT mutation families [26]. | |||||||||||||||
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Lymphocytes and hyperplastic epithelial cells isolated from tissues with the histologic appearance of pancreatitis showed various expression levels of hTERT. | |||||||||||||||
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In the initial decade of the training of TCs in Mozambique there was a clear opinion, above all among senior surgeons, that the introduction of TCs was only acceptable as a temporary solution to a critical problem of scarcity of human resources for health. | |||||||||||||||
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The appreciation from health workers that TCs contribute significantly to a cost reduction has been confirmed in a recent study, in which it was established that the cost-effectiveness of TCs in relation to medical doctors as far as caesarean section is concerned is approximately three times more favourable for TCs than for medical doctors. | |||||||||||||||
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This marked reduction in BrdU label within the stem cell compartment caused by expression of TERTci was comparable to the effect seen with wild-type TERT [3]. | |||||||||||||||
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Human telomerase reverse transcriptase (hTERT) gene expression, using reverse transcriptase-polymerase chain reaction, has been identified as a promising diagnostic marker in distinguishing benign from malignant tumors in materials obtained by FNA. | |||||||||||||||
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Expression of hTERT mRNA and protein was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively. | |||||||||||||||
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However, evaluation of telomere lengths of DNA samples of following generations of TERT mutations has shown a statistical trend toward further telomere shortening for three large kindreds. | |||||||||||||||
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We found that those with a TERT mutation (n? | |||||||||||||||
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Its action on telomeres solves the end-replication problem by counteracting the progressive shortening of the chromosome that occurs with each cell division. hTERT is highly expressed in germ cells, cells with proliferative potential and immortalized cancer cells[3], [4], [5]. | |||||||||||||||
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The human telomerase reverse transcriptase (hTERT) is nearly universally overexpressed in human cancer, contributes critically to oncogenesis, and is recognized by cytotoxic T cells that lyse tumors. | |||||||||||||||
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As expected, CD34, CD45 and TERT could not be detected on any examined time point [see Additional file 2].
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