INT121496

Context Info Confidence 0.78 First Reported 2004 Last Reported 2010 Negated 2 Speculated 3 Reported most in Body Documents 107 Total Number 111 Disease Relevance 45.60 Pain Relevance 7.42

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT) RNA binding (TERT) chromosome (TERT) nucleolus (TERT)

Anatomy Link Frequency telomere 12 myoblast 6 hepatocytes 4 extracellular matrix 3 mononuclear cells 2 TERT (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 140 99.70 cINOD 39 98.44 metalloproteinase 65 98.30 Chronic pancreatitis 17 96.56 Kinase C 1659 96.24 fibrosis 426 94.96 Inflammation 691 93.92 Somatostatin 10 86.32 Enkephalin 15 85.76 Central nervous system 35 85.72

Disease Link Frequency Relevance Heat Repression 140 99.92 Chronic Hepatitis 3 99.82 Cancer 1176 99.72 Carcinoma 38 99.72 Pancreatitis 21 99.68 Liver Disease 30 99.64 Viral Infection 14 99.64 Reprotox - General 1 104 99.58 Generaliased Trisomy 2 99.12 Keloid Scars 1344 98.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Up-regulated human telomerase reverse transcriptase expression was detectable and increased gradually with cancer development and was primarily observed at the borderline IPMN stage and then in more advanced histopathologies.

Gene_expression (expression) of telomerase reverse transcriptase associated with cancer

1) Confidence 0.78 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.23 Pain Relevance 0.08

Telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas.

Gene_expression (expression) of telomerase in Telomere associated with cancer

2) Confidence 0.78 Published 2008 Journal J. Gastrointest. Surg. Section Title Doc Link 17960465 Disease Relevance 1.12 Pain Relevance 0.07

We analyzed telomerase expression in 68 IPMN samples and assessed telomere length by quantitative fluorescence in situ hybridization in samples taken from 17 sequential IPMN patients that included 37 individual loci.

Spec (analyzed) Gene_expression (expression) of telomerase in telomere associated with cancer

3) Confidence 0.78 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.19 Pain Relevance 0.08

Lymphocytes and hyperplastic epithelial cells isolated from tissues with the histologic appearance of pancreatitis showed various expression levels of hTERT.

Gene_expression (expression) of hTERT in epithelial cells associated with pancreatitis and hyperplasia

4) Confidence 0.76 Published 2006 Journal Clin. Cancer Res. Section Abstract Doc Link 16609017 Disease Relevance 1.37 Pain Relevance 0.24

There were significant differences in hTERT expression among carcinoma cells, IPMN cells, and normal ductal cells isolated from pancreatic tissues by microdissection.

Gene_expression (expression) of hTERT associated with cancer and carcinoma

5) Confidence 0.76 Published 2006 Journal Clin. Cancer Res. Section Abstract Doc Link 16609017 Disease Relevance 1.45 Pain Relevance 0.24

We found significant differences in hTERT expression among carcinoma-derived, intraductal papillary mucinous neoplasm (IPMN)-derived, and chronic pancreatitis-derived juice samples.

Gene_expression (expression) of hTERT associated with cancer, carcinoma and chronic pancreatitis

6) Confidence 0.76 Published 2006 Journal Clin. Cancer Res. Section Abstract Doc Link 16609017 Disease Relevance 1.15 Pain Relevance 0.18

METHODS AND RESULTS: We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P53, PCNA, TERT, and XRCC1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation (ACS).

Spec (analyzed) Gene_expression (expression) of TERT in plaques

7) Confidence 0.75 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.19 Pain Relevance 0

The observations in these families suggest that the penetrance of the TERT mutation is incomplete, though substantial (?

Gene_expression (mutation) of TERT

8) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 1.23 Pain Relevance 0.09

This is consistent with a recent report of a wide spectrum of familial liver disease in kindreds with telomerase mutations, including two TERT mutation families [26].

Gene_expression (mutations) of telomerase in liver associated with liver disease

9) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 1.67 Pain Relevance 0.17

Lymphocytes and hyperplastic epithelial cells isolated from tissues with the histologic appearance of pancreatitis showed various expression levels of hTERT.

Gene_expression (levels) of hTERT in epithelial cells associated with pancreatitis and hyperplasia

10) Confidence 0.59 Published 2006 Journal Clin. Cancer Res. Section Abstract Doc Link 16609017 Disease Relevance 1.36 Pain Relevance 0.24

In the initial decade of the training of TCs in Mozambique there was a clear opinion, above all among senior surgeons, that the introduction of TCs was only acceptable as a temporary solution to a critical problem of scarcity of human resources for health.

Gene_expression (introduction) of TCs

11) Confidence 0.59 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.07 Pain Relevance 0

The appreciation from health workers that TCs contribute significantly to a cost reduction has been confirmed in a recent study, in which it was established that the cost-effectiveness of TCs in relation to medical doctors as far as caesarean section is concerned is approximately three times more favourable for TCs than for medical doctors.

Gene_expression (effectiveness) of TCs

12) Confidence 0.59 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.15 Pain Relevance 0

This marked reduction in BrdU label within the stem cell compartment caused by expression of TERTci was comparable to the effect seen with wild-type TERT [3].

Gene_expression (expression) of TERT in stem cell

13) Confidence 0.58 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.32 Pain Relevance 0

Human telomerase reverse transcriptase (hTERT) gene expression, using reverse transcriptase-polymerase chain reaction, has been identified as a promising diagnostic marker in distinguishing benign from malignant tumors in materials obtained by FNA.

Gene_expression (expression) of telomerase reverse transcriptase associated with malignant neoplastic disease

14) Confidence 0.58 Published 2005 Journal Cytojournal Section Body Doc Link PMC1184092 Disease Relevance 1.22 Pain Relevance 0

Expression of hTERT mRNA and protein was detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, respectively.

Gene_expression (Expression) of hTERT

15) Confidence 0.56 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.08 Pain Relevance 0

However, evaluation of telomere lengths of DNA samples of following generations of TERT mutations has shown a statistical trend toward further telomere shortening for three large kindreds.

Gene_expression (generations) of TERT in telomere

16) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 0.69 Pain Relevance 0.05

We found that those with a TERT mutation (n?

Gene_expression (mutation) of TERT

17) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 1.28 Pain Relevance 0.12

Its action on telomeres solves the end-replication problem by counteracting the progressive shortening of the chromosome that occurs with each cell division. hTERT is highly expressed in germ cells, cells with proliferative potential and immortalized cancer cells[3], [4], [5].

Gene_expression (expressed) of hTERT in germ cells associated with cancer

18) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 0.54 Pain Relevance 0.03

The human telomerase reverse transcriptase (hTERT) is nearly universally overexpressed in human cancer, contributes critically to oncogenesis, and is recognized by cytotoxic T cells that lyse tumors.

Gene_expression (overexpressed) of telomerase reverse transcriptase in cytotoxic T cells associated with cancer

19) Confidence 0.54 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974999 Disease Relevance 0.63 Pain Relevance 0

As expected, CD34, CD45 and TERT could not be detected on any examined time point [see Additional file 2].

Neg (not) Gene_expression (detected) of TERT

20) Confidence 0.52 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0

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