INT1215

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1976
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 4.60
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nociceptors 2
plasma 1
fibroblasts 1
PGE (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 3 99.98 Very High Very High Very High
cINOD 42 98.84 Very High Very High Very High
COX-2 inhibitor 3 98.84 Very High Very High Very High
adenocard 2 93.44 High High
local anesthetic 8 90.56 High High
cytokine 2 86.08 High High
Inflammation 47 85.64 High High
Hyperalgesia 4 84.16 Quite High
anesthesia 6 72.16 Quite High
cva 3 68.72 Quite High
Disease Link Frequency Relevance Heat
Fever 8 100.00 Very High Very High Very High
Schizophrenia 8 99.62 Very High Very High Very High
Infection 4 99.12 Very High Very High Very High
Injury 42 96.04 Very High Very High Very High
Pressure And Volume Under Development 2 94.32 High High
Cancer 49 91.80 High High
Intestinal Cancer 3 90.80 High High
Neurosis 2 90.72 High High
Ulcers 63 90.04 High High
Peptic Ulcer 24 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, we have shown that Cox-2 expression is dependent on TLR4 and that, in the absence of TLR4, levels of PGE 2 are greatly reduced.
Negative_regulation (reduced) of PGE
1) Confidence 0.47 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.99 Pain Relevance 0.08
CONCLUSION: The lack of an analgesic effect for dexamethasone while reducing both PGE(2) and TxB(2) at the site of injury in comparison to ketorolac analgesia accompanied by greater reductions in levels of these prostanoids suggests that glucocorticoids at this dose do not suppress PGE(2) release sufficiently to attenuate peripheral sensitization of nociceptors after tissue injury.


Negative_regulation (suppress) of PGE in nociceptors
2) Confidence 0.37 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12966473 Disease Relevance 0.05 Pain Relevance 0
Subsequent administration of ketorolac significantly reduced pain while decreasing both PGE(2) and TxB(2) levels at the surgical site.
Negative_regulation (decreasing) of PGE
3) Confidence 0.37 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12966473 Disease Relevance 0.13 Pain Relevance 0
Administration of dexamethasone suppressed PGE(2) levels in samples collected at pain onset in comparison to placebo and significantly suppressed TxB(2) at the surgical site but without any effect on pain report.
Negative_regulation (suppressed) of PGE
4) Confidence 0.37 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12966473 Disease Relevance 0.15 Pain Relevance 0
CONCLUSION: The lack of an analgesic effect for dexamethasone while reducing both PGE(2) and TxB(2) at the site of injury in comparison to ketorolac analgesia accompanied by greater reductions in levels of these prostanoids suggests that glucocorticoids at this dose do not suppress PGE(2) release sufficiently to attenuate peripheral sensitization of nociceptors after tissue injury.


Negative_regulation (reducing) of PGE in nociceptors
5) Confidence 0.37 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12966473 Disease Relevance 0.12 Pain Relevance 0
We conclude that bupivacaine inhibited PGE(2)EP(1) receptor signaling at clinically relevant concentrations.
Negative_regulation (inhibited) of PGE
6) Confidence 0.28 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11524330 Disease Relevance 0 Pain Relevance 0.22
Bupivacaine, after incubation for 10 min, inhibited concentration-dependent PGE(2)EP(1) receptor functioning (half-maximal inhibitory effect concentration, 3.06 +/- 1.26 x 10(-6) M).
Negative_regulation (inhibited) of PGE
7) Confidence 0.28 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11524330 Disease Relevance 0.24 Pain Relevance 0.38
Deletion of mPGES-1 also depressed urinary PGE-M, whereas it augmented excretion of PGD(2) and PGI(2) metabolites, reflecting rediversion of the accumulated PGH(2) substrate in the double knockouts.
Negative_regulation (depressed) of PGE-M
8) Confidence 0.25 Published 2008 Journal Circulation Section Body Doc Link 18285567 Disease Relevance 0.22 Pain Relevance 0
Results demonstrate that vedaprofen had no effect on blood plasma concentration of PG-metabolite but significantly inhibited both, PGF and PGE concentrations in seminal plasma.
Negative_regulation (inhibited) of PGE in plasma
9) Confidence 0.21 Published 2005 Journal Theriogenology Section Abstract Doc Link 15955550 Disease Relevance 0.16 Pain Relevance 0
In endotoxin treated animals paracetamol reduced the fever reaction and both PGE and cyclic AMP levels.
Negative_regulation (reduced) of PGE associated with paracetamol and fever
10) Confidence 0.21 Published 1976 Journal Pflugers Arch. Section Abstract Doc Link 177944 Disease Relevance 0.36 Pain Relevance 0.18
We hypothesize that blocking PGE(2) with NS-398, a selective COX-2 inhibitor, will modulate this response and improve outcome.
Negative_regulation (blocking) of PGE associated with cox-2 inhibitor
11) Confidence 0.21 Published 2001 Journal J. Surg. Res. Section Abstract Doc Link 11368536 Disease Relevance 0.59 Pain Relevance 0.33
Ulceration also reduced (71%) the mucosal PGE, compared to that in normal mice.
Negative_regulation (reduced) of PGE
12) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.15 Pain Relevance 0
The NSAIDs exert both their therapeutic and toxic effects mainly by decreasing the levels of circulating PGE at the gastric mucosa via inhibition of the COX isozymes.
Negative_regulation (decreasing) of PGE associated with cinod
13) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.31 Pain Relevance 0.17
The serum PGE level was decreased (70%) on the 3rd day of ulceration, compared to that in normal mice (Figure 7).
Negative_regulation (decreased) of PGE
14) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.06 Pain Relevance 0
The two hypotheses--PGE deficiency and PGE excess--are not compatible because of the bell shape dose response curve with PG's in certain biological systems.
Negative_regulation (deficiency) of PGE
15) Confidence 0.11 Published 1982 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6287532 Disease Relevance 0.42 Pain Relevance 0.10
Clinical observations and experimental findings are rendered which have raised the possibility that schizophrenia may be related to PGE deficiency and/or excess. 2.
Negative_regulation (deficiency) of PGE associated with schizophrenia
16) Confidence 0.11 Published 1982 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6287532 Disease Relevance 0.38 Pain Relevance 0.06
Administration of 30 mg ketorolac tromethamine produced parallel decreases in pain, PGE(2) levels, and TxB(2) levels at the surgical site.
Negative_regulation (decreases) of PGE
17) Confidence 0.10 Published 2002 Journal Clin. Pharmacol. Ther. Section Body Doc Link 12189364 Disease Relevance 0.12 Pain Relevance 0
The analgesic effects of 1 mg ketorolac tromethamine without a reduction in PGE(2) at the site of injury suggests an additional central site for NSAID analgesia.


Negative_regulation (reduction) of PGE
18) Confidence 0.10 Published 2002 Journal Clin. Pharmacol. Ther. Section Body Doc Link 12189364 Disease Relevance 0 Pain Relevance 0
RESULTS: At experimental sides, total amount of GCF PGE(2), P substances(SP), IL-6 and GM-CSF levels was significantly elevated compared with that before activation.
Negative_regulation (amount) of PGE
19) Confidence 0.03 Published 2003 Journal Shanghai Kou Qiang Yi Xue Section Body Doc Link 14966604 Disease Relevance 0.08 Pain Relevance 0
These results show that there is a significant decrease in PGE(2) levels of synovial fibroblasts undergoing mechanical strain.
Negative_regulation (decrease) of PGE in fibroblasts
20) Confidence 0.02 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12796883 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox