INT12150

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Context Info
Confidence 0.55
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 1.91
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGKV1-5)
Anatomy Link Frequency
neurons 5
neuronal 2
gray matter 1
radius 1
tendons 1
IGKV1-5 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 38 98.34 Very High Very High Very High
antagonist 5 93.08 High High
tetrodotoxin 6 91.20 High High
Thalamus 3 68.08 Quite High
Buprenorphine 1 65.96 Quite High
analgesia 1 64.32 Quite High
addiction 16 61.44 Quite High
Central nervous system 25 55.40 Quite High
isoflurane 1 55.16 Quite High
halothane 5 53.20 Quite High
Disease Link Frequency Relevance Heat
Uterine Fibroids 120 98.88 Very High Very High Very High
Cognitive Disorder 13 98.16 Very High Very High Very High
Hypertension 12 97.36 Very High Very High Very High
Heart Rate Under Development 1 86.00 High High
Ganglion Cysts 11 83.08 Quite High
Optic Nerve Injuries 35 77.04 Quite High
Tendinopathy 2 65.56 Quite High
Adhesions 3 47.12 Quite Low
Injury 14 39.92 Quite Low
Ocular Hypertension 71 38.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, an absence of V1 activity to global form in Glass patterns was also noted using fMRI, where such anatomical considerations are not pertinent (unpublished observations).
Negative_regulation (absence) of V1
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0
Eighty percent of the sites recorded in the retinotopically corresponding region of MT during inactivation of V1 were found to be visually responsive.
Negative_regulation (inactivation) of V1
2) Confidence 0.43 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0
It was found that, during inactivation of V1, the preferred direction changed for most neurons but remained close to the preferred direction or to its opposite in the control situation.
Negative_regulation (inactivation) of V1 in neurons
3) Confidence 0.43 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0
Another possible reason for the lack of V1 activity relates to its anatomical structure, and the nature of magnetic fields.
Negative_regulation (lack) of V1 in anatomical structure
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0
An absence of V1 activity to global form was noted by both Braddick et al. [2] and Wilkinson et al. [11].
Negative_regulation (absence) of V1
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2974635 Disease Relevance 0 Pain Relevance 0
Response selectivity of neurons in area MT of the macaque monkey during reversible inactivation of area V1.
Negative_regulation (inactivation) of V1 in neurons associated with anesthesia
6) Confidence 0.38 Published 1992 Journal J. Neurophysiol. Section Title Doc Link 1629756 Disease Relevance 0 Pain Relevance 0.10
These authors also tested the effect of a reversible block of area V1 on the visual responses of a small number of neurons in area MT and showed that most of these cells remain visually responsive.
Negative_regulation (block) of V1 in neurons
7) Confidence 0.38 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0
During inactivation of V1, the average tuning curve of neurons became broader mostly because of strong reductions in the response to directions close to the preferred and nonpreferred.
Negative_regulation (inactivation) of V1 in neurons
8) Confidence 0.38 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1629756 Disease Relevance 0 Pain Relevance 0.09
Nevertheless, studies in which single- or multi-unit activity was recorded in the minutes following transient inactivation of V1 by cooling report that >95% of V2, V3 sites stop responding entirely to the visual stimulus [1], [3], [25].
Negative_regulation (inactivation) of V1
9) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
The loss of V1 gray matter was clearly detectable in the MR anatomical images (0.5 mm3 resolution anatomical Mdeft scan [34], [35]; Figure 1C), so that the lesioned area could be selected independently of functional activity as an ROI for further analysis.
Negative_regulation (loss) of V1 in gray matter
10) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Each of V1, V2 and V3 mRNA showed significant decreases in expression in painful and ruptured tendons, but V0 was not significantly changed.
Negative_regulation (decreases) of V1 in tendons
11) Confidence 0.11 Published 2004 Journal Rheumatology (Oxford) Section Body Doc Link 15138331 Disease Relevance 0.07 Pain Relevance 0
8m and greater, variant V1 was down-regulated (0·71 ± 0·13; P < 0·05) in leiomyomas.
Negative_regulation (down-regulated) of V1 associated with uterine fibroids
12) Confidence 0.09 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.66 Pain Relevance 0
As discussed below, our findings make it unlikely that the binding of local features relevant for scene segmentation takes place in V1, which is probably accomplished in higher areas.


Negative_regulation (accomplished) of V1
13) Confidence 0.04 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2882822 Disease Relevance 0 Pain Relevance 0
The combined blockage of V1 and alpha receptors, also caused a higher decrease in the MAP of hypertensive group than, of normotensive group, not depending on the order of the injections (p < 0.01).
Negative_regulation (blockage) of V1 associated with hypertension
14) Confidence 0.04 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10789696 Disease Relevance 0.93 Pain Relevance 0.23
Area V1 was blocked such that it could be gently flattened tangentially between two glass slides before being frozen on dry ice and stored at ?
Negative_regulation (blocked) of V1
15) Confidence 0.04 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773743 Disease Relevance 0.08 Pain Relevance 0.33
We conclude that V1 blockade did not have any important role in the cardiovascular response to acute hypoxemia in the llama fetus, in contrast with lowland fetuses.
Negative_regulation (blockade) of V1
16) Confidence 0.03 Published 2000 Journal High Alt. Med. Biol. Section Abstract Doc Link 11254227 Disease Relevance 0 Pain Relevance 0.13
In V1, as a consequence of visual deprivation, the population of neurons responsive to the intact eye increases [18,22].
Negative_regulation (deprivation) of V1 in neurons
17) Confidence 0.02 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0.08 Pain Relevance 0.18
Levitt and Lund (2002; median SI: 0.33) and Cavanaugh et al. (2002; mean SI: 0.38) reported weaker average suppression in V1.
Negative_regulation (suppression) of V1
18) Confidence 0.01 Published 2009 Journal Journal of Neurophysiology Section Body Doc Link PMC2775374 Disease Relevance 0 Pain Relevance 0.09
In both V1 and V2, as the inner radius of the annular grating was decreased—i.e., as more of the far surround region was stimulated (read the x-axes in Fig. 7 from right to left)—the cell's response was suppressed.
Negative_regulation (decreased) of V1 in radius
19) Confidence 0.01 Published 2009 Journal Journal of Neurophysiology Section Body Doc Link PMC2775374 Disease Relevance 0 Pain Relevance 0
Consistent with Sceniak et al. (2001), surround suppression in V1, measured with either method, was significantly stronger in the upper layers (4B and above).
Negative_regulation (suppression) of V1 in upper
20) Confidence 0.01 Published 2009 Journal Journal of Neurophysiology Section Body Doc Link PMC2775374 Disease Relevance 0 Pain Relevance 0

General Comments

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