INT121531

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 3.46
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DNMT3B) nucleus (DNMT3B) DNA binding (DNMT3B)
cytoplasm (DNMT3B)
Anatomy Link Frequency
TMJ 1
condyle 1
DNMT3B (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 293 99.66 Very High Very High Very High
Nicotine 3 99.22 Very High Very High Very High
antagonist 2 98.80 Very High Very High Very High
cannabis 52 90.08 High High
Ventral tegmentum 1 89.00 High High
Pyramidal cell 2 87.80 High High
gABA 6 83.68 Quite High
Cannabinoid 9 82.60 Quite High
GABAergic 18 78.76 Quite High
Hippocampus 1 77.52 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 298 99.66 Very High Very High Very High
Volume Depletion And Dehydration 36 96.44 Very High Very High Very High
Schizophrenia 106 93.04 High High
Cannabis Dependence 24 90.08 High High
Cognitive Disorder 18 81.52 Quite High
Pressure Volume 2 Under Development 12 80.80 Quite High
Disease 32 71.64 Quite High
Pain 56 68.00 Quite High
Rheumatoid Arthritis 152 62.28 Quite High
Alcohol Addiction 1 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Open reduction for ICF can restore the anatomic position for both the condyle and TMJ soft tissues with few complications, which can yield better functional and radiologic results.


Negative_regulation (reduction) of ICF in condyle
1) Confidence 0.36 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19615581 Disease Relevance 0 Pain Relevance 0
At the beginning of each focus group, the procedure of the session was explained, and the concept of the ICF was presented in lay terms to all participants.
Negative_regulation (presented) of ICF
2) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779412 Disease Relevance 0.05 Pain Relevance 0
As the ICF has been developed in a worldwide, comprehensive consensus process over the past few years and was endorsed by the WHA as a member of the WHO Family of International Classifications, it is likely to become the generally accepted framework to describe functioning and health.
Negative_regulation (endorsed) of ICF
3) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779412 Disease Relevance 0.19 Pain Relevance 0.06
CONCLUSION: A formal consensus process integrating evidence and expert opinion based on the ICF framework and classification led to the definition of ICF Core Sets for chronic widespread pain.
Negative_regulation (definition) of ICF
4) Confidence 0.34 Published 2004 Journal J Rehabil Med Section Body Doc Link 15370750 Disease Relevance 0 Pain Relevance 0
CONCLUSION: A formal consensus process integrating evidence and expert opinion based on the ICF framework and classification led to the definition of ICF Core Sets for low back pain.
Negative_regulation (definition) of ICF
5) Confidence 0.33 Published 2004 Journal J Rehabil Med Section Body Doc Link 15370751 Disease Relevance 0 Pain Relevance 0
This problem applies partly to the ICF classification and partly to the reduction of ICF categories in the present Comprehensive ICF Core Set.
Negative_regulation (reduction) of ICF
6) Confidence 0.25 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.39 Pain Relevance 0.39
The candidate item sets to be used as an item bank in CAT was designed to be applicable to patients with a spectrum of LBP problems and to represent the ICF components of disability [7] and the ICF core set for LBP [25].
Negative_regulation (represent) of ICF associated with backache
7) Confidence 0.23 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651163 Disease Relevance 0.64 Pain Relevance 0.50
Likewise, atropine, a cholinergic antagonist, has been found to enhance ICF (Liepert et al. 2001), while NMDA antagonists and chronic nicotine exposure have been associated with an ICF reduction (Lang et al. 2008; Schwenkreis et al. 1999; Ziemann et al. 1998).
Negative_regulation (reduction) of ICF associated with nicotine and antagonist
8) Confidence 0.22 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.24 Pain Relevance 0.77
This problem applies partly to the ICF classification and partly to the reduction of ICF categories in the present Comprehensive ICF Core Set.
Negative_regulation (reduction) of ICF
9) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.40 Pain Relevance 0.40
The present results also indicate that some important problems covered by the ICF classification disappear in the reduction of categories for the Comprehensive ICF Core Set for LBP.
Negative_regulation (reduction) of ICF associated with backache
10) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.70 Pain Relevance 0.48
Thus, in the development of a Comprehensive ICF Core Set for LBP one should address to which extent the most important problems reported by the patients are represented.
Negative_regulation (development) of ICF associated with backache
11) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.45 Pain Relevance 0.45
Open reduction for ICF can restore the anatomic position for both the condyle and TMJ soft tissues with few complications, which can yield better functional and radiologic results.


Negative_regulation (reduction) of ICF in TMJ
12) Confidence 0.12 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19615581 Disease Relevance 0 Pain Relevance 0
The sleeping period is associated with a progressive decrease in the ECF volume that is concomitant to the decrease in the ICF volume.
Negative_regulation (decrease) of ICF
13) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0 Pain Relevance 0
The ICF volume is simultaneously reduced by 5% (Figure 7C) to buffer the increase in ECF [Na+].
Negative_regulation (reduced) of ICF
14) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0.22 Pain Relevance 0
The reduction in the ICF compartment reaches 3% of its initial volume in a short interval, causing intracellular dehydration.
Negative_regulation (reduction) of ICF associated with volume depletion and dehydration
15) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0.18 Pain Relevance 0

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