INT12156

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 43
Total Number 44
Disease Relevance 17.75
Pain Relevance 12.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MET) signal transduction (MET) plasma membrane (MET)
Anatomy Link Frequency
HGF 5
hepatocyte 4
plasma 2
brain 2
PFC 2
MET (Homo sapiens)
MET - F4M (1) MET - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 61 100.00 Very High Very High Very High
substance P 60 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
monoamine 5 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
Catechol-O-methyltransferase 121 99.70 Very High Very High Very High
opiate 9 99.68 Very High Very High Very High
Hippocampus 10 99.60 Very High Very High Very High
Endogenous opioid 9 99.40 Very High Very High Very High
Dopamine 34 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 99.96 Very High Very High Very High
Epilepsy 8 99.74 Very High Very High Very High
Osteoarthritis 2 99.72 Very High Very High Very High
Myocardial Infarction 5 99.68 Very High Very High Very High
Fibrosis 18 99.64 Very High Very High Very High
Muscular Atrophy 13 99.52 Very High Very High Very High
Dog Diseases 2 99.28 Very High Very High Very High
Basal Ganglia Disease 1 99.24 Very High Very High Very High
Cancer 712 99.22 Very High Very High Very High
Endometriosis 138 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with > 80% decrease in caudate nucleus DA content, there was a three-fold increase in both Met-enk and SP levels in GPM.
Positive_regulation (increase) of Met in caudate nucleus associated with dopamine and substance p
1) Confidence 0.67 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 7504224 Disease Relevance 0.43 Pain Relevance 0.67
RESULTS: Twenty percent of the operated infants showed elevated Met-Hb levels (median of maximal levels: 6%; range: 2.2-18%) at admission on the PICU.
Positive_regulation (elevated) of Met
2) Confidence 0.67 Published 2008 Journal Paediatr Anaesth Section Body Doc Link 18184243 Disease Relevance 0.08 Pain Relevance 0
Expression of cathepsin L resulted in highly increased cellular levels of (Met)enkephalin, resulting from the conversion of PE to enkephalin-containing intermediates of 23, 18-19, 8-9, and 4.5 kDa that were similar to those present in vivo.
Positive_regulation (increased) of Met associated with enkephalin
3) Confidence 0.67 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 0.80
The accumulation of amino acids, monoamines and D-Ala2-Met-enkephalinamide (Enk) was visualized by autoradiography in astroglial primary cultures from different well-defined brain areas.
Positive_regulation (accumulation) of Met (A2M) in brain associated with monoamine
4) Confidence 0.67 Published 1983 Journal Brain Res. Section Abstract Doc Link 6140983 Disease Relevance 0 Pain Relevance 0.35
Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP.
Positive_regulation (elevated) of Met associated with enkephalin
5) Confidence 0.49 Published 1995 Journal J. Biol. Chem. Section Title Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.48
The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced after i.c.v. administration.
Positive_regulation (restricting) of Met (F4M) in respiratory associated with agonist, enkephalin and opiate
6) Confidence 0.49 Published 1982 Journal Life Sci. Section Abstract Doc Link 6819420 Disease Relevance 0 Pain Relevance 0.68
Brain enkephalin receptors were studied in post-mortem brain samples of 27 patients with Parkinson's disease and of 26 control subjects without extrapyramidal disorders by the radioligand-binding technique using 3H-leu-enkephalin, 3H-met-enkephalin and 3H-naloxone.
Positive_regulation (using) of met in Brain associated with narcan, basal ganglia disease, enkephalin and disease
7) Confidence 0.49 Published 1983 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 6321647 Disease Relevance 0.33 Pain Relevance 0.78
Plasma levels of the endogenous opioid peptides beta-endorphin and [Met]enkephalin were estimated in 10 osteoarthritic patients during treatment with a sustained-release indomethacin preparation (Osmosin).
Positive_regulation (estimated) of Met in Plasma associated with endogenous opioid, enkephalin and osteoarthritis
8) Confidence 0.49 Published 1985 Journal Br. J. Rheumatol. Section Abstract Doc Link 3156655 Disease Relevance 0.43 Pain Relevance 0.56
In the 6 patients with the longest tolerance times for forearm ischemic pain (all in group A) and in the 5 having the shortest tolerance times (all in group B), plasma levels of beta endorphin, met-enkephalin, noradrenaline and adrenaline were similar during both the basal state and the induction of forearm ischemic pain.
Positive_regulation (similar) of met in forearm associated with pain, noradrenaline, tolerance and enkephalin
9) Confidence 0.49 Published 1986 Journal Am. J. Cardiol. Section Abstract Doc Link 2945417 Disease Relevance 0.96 Pain Relevance 1.24
In addition, these compounds inhibited the f-Met-Leu-Phe (FMLP)-induced MPO release from PMN.
Positive_regulation (-induced) of Met in PMN associated with urological neuroanatomy
10) Confidence 0.49 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.44 Pain Relevance 0.49
Sauna-induced hyperthermia resulted in an increase of plasma beta-EP and ACTH, but appeared to have no significant effect on circulating Met-enk.
Positive_regulation (circulating) of Met in plasma associated with fever
11) Confidence 0.49 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 2155166 Disease Relevance 0.36 Pain Relevance 0.17
Nerves displaying immunoreactivity (ir) for the proenkephalin (PRO-ENK) derivatives met-enkephalin (ME), leuenkephalin (LE), octapeptide, and heptapeptide (ordered in decreasing frequency) were present in the dorsolateral stroma of human prostate.
Positive_regulation (derivatives) of met in Nerves associated with enkephalin
12) Confidence 0.49 Published 1989 Journal Prostate Section Abstract Doc Link 2734247 Disease Relevance 0 Pain Relevance 0.37
In PMNLs obtained from healthy aged male subjects, Met-enk induced in all of the applied concentrations an increased cAMP level and no change in cGMP level, with subsequent decrease of cytotoxicity, i.e. an impaired negative coupling of naloxone sensitive opiate receptors was detected with aging.
Positive_regulation (induced) of Met associated with aging, narcan and opiate
13) Confidence 0.49 Published 1987 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2826349 Disease Relevance 0.09 Pain Relevance 0.42
activation loop or in the ATP-binding pocket and cause ligand-independent MET
Positive_regulation (cause) of MET
14) Confidence 0.46 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.40 Pain Relevance 0
The local amine anesthetic tetracaine added to a suspension of guinea pig or human neutrophilic granulocytes inhibited their random migration in Boyden chambers, but increased their chemotactic migration towards the chemotactic tripeptide f-Met-Leu-Phe, complement-activated normal guinea pig serum, and the eosinophil chemotactic factor ECF.
Positive_regulation (increased) of Met in eosinophil
15) Confidence 0.45 Published 1983 Journal Immunobiology Section Abstract Doc Link 6885104 Disease Relevance 0 Pain Relevance 0.07
In this study, PTP was examined during elevation of cellular [Met]enkephalin by forskolin, a direct activator of adenylate cyclase that produces cAMP.
Spec (examined) Positive_regulation (elevation) of Met associated with enkephalin
16) Confidence 0.45 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7768928 Disease Relevance 0 Pain Relevance 0.48
These results indicate increased levels of (Met)enkephalin within secretory vesicles of the regulated secretory pathway.
Positive_regulation (increased) of Met in vesicles associated with enkephalin
17) Confidence 0.45 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17244622 Disease Relevance 0 Pain Relevance 1.03
In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptide Met-enkephalin-Arg6-Gly7-Leu8 in the mesencephalon and striatum, while the level of the prodynorphin-derived peptide alpha-neoendorphin was increased in the striatum and hippocampus.
Positive_regulation (elevated) of Met in hippocampus associated with epilepsy, hippocampus and enkephalin
18) Confidence 0.45 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630600 Disease Relevance 0.72 Pain Relevance 0.39
Further analyses revealed that the main effect for COMTval158met genotype was driven by the three post Remifentanil provocations (T3–T5), which demonstrated a consistent effect for COMTval158met with no interaction with T.
Positive_regulation (effect) of COMTval158met associated with ultiva
19) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695541 Disease Relevance 0.59 Pain Relevance 0.89
This indicates the ability of hepatocytes to proliferate after c-MET activation in more chronic stages while cirrhotic samples do not complete the cell-cycle of which the cause remains to be elucidated.
Positive_regulation (activation) of c-MET in hepatocytes associated with cirrhosis
20) Confidence 0.34 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.59 Pain Relevance 0.03

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