INT121561

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 1.20

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transport (Sdhb) mitochondrion (Sdhb) oxidoreductase activity (Sdhb)
Anatomy Link Frequency
brain 2
Sdhb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 44 100.00 Very High Very High Very High
Dopamine 2 98.88 Very High Very High Very High
anesthesia 2 67.00 Quite High
Disease Link Frequency Relevance Heat
Immunization 14 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the attenuation of the reinforcing effect of nicotine after immunization with IP18-KLH, shown previously, is indeed associated with an altered distribution of nicotine.
Negative_regulation (attenuation) of IP18-KLH Binding (immunization) of associated with nicotine and immunization
1) Confidence 0.41 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15375641 Disease Relevance 0.51 Pain Relevance 0.76
We have previously shown that active immunization with the nicotine immunoconjugate IP18-KLH attenuates the reinforcing effects of nicotine, i.e., suppresses the nicotine-induced brain dopamine release and prevents reinstatement of the nicotine-seeking behavior in rats.
Negative_regulation (suppresses) of IP18-KLH Binding (immunization) of in brain associated with dopamine, nicotine and immunization
2) Confidence 0.36 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15375641 Disease Relevance 0.23 Pain Relevance 0.44

General Comments

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