INT12157

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 14.54
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
leukocyte 7
neutrophil 3
cartilage 1
striatum 1
Schwann cells 1
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 19 100.00 Very High Very High Very High
ischemia 10 100.00 Very High Very High Very High
lidocaine 5 98.24 Very High Very High Very High
Angina 9 98.16 Very High Very High Very High
local anesthetic 3 98.04 Very High Very High Very High
Neuritis 1 97.48 Very High Very High Very High
Inflammation 152 97.24 Very High Very High Very High
cytokine 117 97.00 Very High Very High Very High
Hippocampus 4 94.36 High High
Spinal cord 3 93.68 High High
Disease Link Frequency Relevance Heat
Adhesions 249 100.00 Very High Very High Very High
Coronary Artery Disease 13 100.00 Very High Very High Very High
Common Cold 8 99.76 Very High Very High Very High
Epilepsy 8 99.74 Very High Very High Very High
Necrosis 15 99.56 Very High Very High Very High
Cancer 15 99.38 Very High Very High Very High
Cardiovascular Disease 23 99.28 Very High Very High Very High
Brain Injury 288 99.10 Very High Very High Very High
Syndrome 7 98.84 Very High Very High Very High
Cv General 3 Under Development 11 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the increase in preproenkephalin mRNA is apparently not enough to yield a measurable increase in the proenkephalin-derived peptide met5-enkephalin-Arg6-Gly7-Leu8, the levels of which showed no significant change during the 14-day inflammatory period.
Positive_regulation (increase) of Leu8 associated with inflammation and enkephalin
1) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 2900057 Disease Relevance 0.47 Pain Relevance 1.06
Results of this study show that leukocytes from TBI patients resuscitated with NS display rapid induction of constitutively expressed CD62L and activation of CD11b with translocation to the cell membrane from intracellular secretory granules [31].
Positive_regulation (induction) of CD62L in leukocytes associated with brain injury
2) Confidence 0.61 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.01 Pain Relevance 0.15
Furthermore, the current results showing reduced surface expression of CD62L in HSD-treated patients, accompanied by corresponding increases in sL-selectin and better patient outcome, are in accordance with our previous findings in shock patients [14], and supports the theory that sL-selectin shedding represents an endogenous regulatory mechanism to limit leukocyte-mediated injury [79].


Positive_regulation (increases) of sL-selectin in leukocyte associated with injury and shock
3) Confidence 0.53 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.98 Pain Relevance 0.18
We investigated the induction of adhesion molecules such as L-selectin, E-selectin, ICAM-1, VCAM-1 and Mac-1 on Schwann cells by proinflammatory cytokines.
Spec (investigated) Positive_regulation (nduction ) of L-selectin in Schwann cells associated with adhesions and cytokine
4) Confidence 0.48 Published 1999 Journal J. Neurol. Sci. Section Abstract Doc Link 10561528 Disease Relevance 0.56 Pain Relevance 0.32
In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptide Met-enkephalin-Arg6-Gly7-Leu8 in the mesencephalon and striatum, while the level of the prodynorphin-derived peptide alpha-neoendorphin was increased in the striatum and hippocampus.
Positive_regulation (elevated) of Leu8 in hippocampus associated with epilepsy, hippocampus and enkephalin
5) Confidence 0.45 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630600 Disease Relevance 0.73 Pain Relevance 0.44
[Met] enkephalin, [Leu] enkephalin and the related heptapeptide [Met] enkephalin-Arg6-Phe7 and octapeptide [Met] enkephalin-Arg6-Gly7-Leu8 are derived from proenkephalin.
Positive_regulation (derived) of Leu8 associated with enkephalin
6) Confidence 0.45 Published 1988 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 3059981 Disease Relevance 0 Pain Relevance 0.97
The cationic local anesthetic lidocaine inhibited not only FMLP-induced O2- release in neutrophils but also FMLP-induced CD11b upregulation and LAM-1 downregulation on neutrophils in a dose-dependent manner.
Positive_regulation (upregulation) of LAM-1 in neutrophils associated with lidocaine and local anesthetic
7) Confidence 0.44 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.24 Pain Relevance 0.66
Consistent with these findings, studies in humans and animals demonstrate upregulated cell-surface CD62L and CD11b expression on leukocytes following polytrauma and isolated head-injury [57].
Positive_regulation (upregulated) of CD62L in leukocytes associated with injury
8) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.13 Pain Relevance 0.14
Circulating sL-selectin levels were significantly elevated at 12 and 48, but not 24 h post-resuscitation with HSD.
Positive_regulation (elevated) of sL-selectin
9) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819256 Disease Relevance 0.66 Pain Relevance 0.11
Moreover, ropivacaine inhibited the tumor necrosis factor alpha-induced up-regulation of CD11b/CD18 and L-selectin shedding by human leukocytes in vitro.
Positive_regulation (up-regulation) of L-selectin in leukocytes associated with necrosis and cancer
10) Confidence 0.29 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9336308 Disease Relevance 0.86 Pain Relevance 0.16
In comparison with three groups of non-epileptic controls, these epileptic rats had an elevated level of the proenkephalin-derived peptide Met-enkephalin-Arg6-Gly7-Leu8 in the mesencephalon and striatum, while the level of the prodynorphin-derived peptide alpha-neoendorphin was increased in the striatum and hippocampus.
Positive_regulation (elevated) of Leu8 in striatum associated with epilepsy, hippocampus and enkephalin
11) Confidence 0.15 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630600 Disease Relevance 0.73 Pain Relevance 0.44
Our study indicates this activation by elevated sL-selectin level as an important discriminant parameter.
Positive_regulation (elevated) of sL-selectin
12) Confidence 0.10 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.73 Pain Relevance 0.21
We studied the effect of atrial pacing induced myocardial ischemia on levels of soluble L-selectin (sL-selectin) and generation of neutrophil derived reactive oxygen species (ROS) in 10 patients with coronary artery disease (CAD) and stable angina and in six individuals without CAD.
Positive_regulation (induced) of sL-selectin in neutrophil associated with angina, coronary artery disease and ischemia
13) Confidence 0.08 Published 2000 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 10750129 Disease Relevance 0.84 Pain Relevance 0.22
Neutralizing antibodies for ICAM-1, VCAM-1, and activated leukocyte-cell adhesion molecule, separately or together, inhibited attachment of human synovial MSCs to human cartilage defects (Figure 4d).
Positive_regulation (activated) of leukocyte-cell adhesion molecule in cartilage associated with adhesions
14) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.59 Pain Relevance 0
In this research, human synovial MSCs attached to the cartilage defect 10 minutes after plating already expressed ICAM-1 and VCAM-1, and neutralizing antibodies for ICAM-1, VCAM-1, or activated leukocyte-cell adhesion molecule inhibited the attachment.
Positive_regulation (activated) of leukocyte-cell adhesion molecule in leukocyte associated with focal cartilage defect and adhesions
15) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.56 Pain Relevance 0
g/ml neutralizing antibody for human ICAM-1, VCAM-1, activated leukocyte-cell adhesion molecule, or mouse IgG1 isotype control antibody (R&D Systems) for 30 minutes at 37°C with 5% humidified CO2 [26].
Positive_regulation (activated) of leukocyte-cell adhesion molecule in leukocyte associated with adhesions
16) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575632 Disease Relevance 0.41 Pain Relevance 0
Intercellular adhesion molecule 1-positive cells increased between 1 minute and 10 minutes, and neutralizing antibodies for intercellular adhesion molecule 1, vascular cell adhesion molecule 1 and activated leukocyte-cell adhesion molecule inhibited the attachment.


Positive_regulation (activated) of leukocyte-cell adhesion molecule in leukocyte associated with adhesions
17) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575632 Disease Relevance 0.69 Pain Relevance 0
Five parameters were unique to each classifier, while increased C5 and sL-selectin serum concentration, increased neutrophil percentage or count and elevated hematocrit were selected by both classification methods as discriminant factors.
Positive_regulation (increased) of sL-selectin in neutrophil
18) Confidence 0.04 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 0.57 Pain Relevance 0.03
The sL-selectin level was significantly increased in patients with restenosis early after PCI, whereas in patients without restenosis, sL-selectin remained unchanged.
Positive_regulation (increased) of sL-selectin associated with cardiovascular disease
19) Confidence 0.03 Published 2005 Journal Pathophysiol. Haemost. Thromb. Section Abstract Doc Link 16293980 Disease Relevance 1.79 Pain Relevance 0.44
A significant and time-dependent increase in sL-selectin was observed in the restenosis group.
Positive_regulation (increase) of sL-selectin associated with cardiovascular disease
20) Confidence 0.01 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 1.00 Pain Relevance 0.19

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