INT12158

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2009
Negated 4
Speculated 8
Reported most in Abstract
Documents 5
Total Number 13
Disease Relevance 0.99
Pain Relevance 11.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
brain 12
spinal cord 4
spinal 2
juvenile 2
forebrain 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 116 100.00 Very High Very High Very High
Morphine 44 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
dopamine receptor 2 100.00 Very High Very High Very High
cocaine 6 99.24 Very High Very High Very High
Opioid 10 99.02 Very High Very High Very High
Spinal cord 20 98.52 Very High Very High Very High
tolerance 3 97.92 Very High Very High Very High
cerebral cortex 18 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 1 98.64 Very High Very High Very High
Urological Neuroanatomy 1 98.16 Very High Very High Very High
Neuropathic Pain 6 91.92 High High
Frailty 3 90.32 High High
Morphine Dependence 9 90.08 High High
Eating Disorder 1 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the previously reported modulatory action of opioids on central CCKergic systems could occur without affecting the preproCCK gene transcription and the tissue peptide concentrations.
Neg (without) Regulation (affecting) of Transcription (transcription) of CCK associated with opioid
1) Confidence 0.60 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0.09 Pain Relevance 1.08
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of Transcription (levels) of cholecystokinin in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
2) Confidence 0.45 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.76
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of Transcription (levels) of CCK mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
3) Confidence 0.45 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of Transcription (levels) of CCK in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
4) Confidence 0.44 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.79
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of Transcription (levels) of pro cholecystokinin mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
5) Confidence 0.40 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80
In the present animal model, cocaine exposure in utero had no significant effect on mRNA levels of the dopamine transporter, D1 or D2 dopamine receptors, enkephalin, tyrosine hydroxylase, or cholecystokinin in juvenile rats.
Neg (no) Regulation (effect) of Transcription (levels) of cholecystokinin in juvenile associated with dopamine, dopamine receptor, enkephalin, cholecystokinin and cocaine
6) Confidence 0.28 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7909578 Disease Relevance 0.08 Pain Relevance 0.74
Following spinal hemisection, CCK mRNA expression increased on the ipsilateral side at the spinal segments caudal to the injury and both sides of the spinal L4-5 segments without any significant changes in CCK(B) receptor mRNA levels.
Neg (without) Regulation (changes) of Transcription (levels) of CCK in spinal associated with injury and cholecystokinin
7) Confidence 0.27 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19619609 Disease Relevance 0.72 Pain Relevance 1.15
While increased enkephalin mRNA expression in the striatum ipsilateral to the lesion was detected, no change of cholecystokinin mRNA expression was observed in any forebrain on the lesioned side, suggesting that cholecystokinin expression in the forebrain is not under dopaminergic control.
Neg (no) Regulation (change) of Transcription (expression) of cholecystokinin in forebrain associated with enkephalin and cholecystokinin
8) Confidence 0.27 Published 1989 Journal Neuroscience Section Abstract Doc Link 2566954 Disease Relevance 0 Pain Relevance 0.68
Tolerance to the alkaloid after s.c. implantation of morphine pellets for three days was not associated with any change in the levels of both CCK like-material (CCKLM) and proCCK mRNA in the frontal cortex.
Regulation (change) of Transcription (levels) of CCK in frontal cortex associated with tolerance, urological neuroanatomy, cholecystokinin and morphine
9) Confidence 0.27 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10670411 Disease Relevance 0.10 Pain Relevance 1.10
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of in spinal cord Transcription (levels) of cholecystokinin in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
10) Confidence 0.15 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.76
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of in spinal cord Transcription (levels) of CCK mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
11) Confidence 0.15 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of in spinal cord Transcription (levels) of CCK in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
12) Confidence 0.15 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.79
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Spec (examined) Regulation (effects) of in spinal cord Transcription (levels) of pro cholecystokinin mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
13) Confidence 0.13 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80

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