INT121586

Context Info Confidence 0.23 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 0.86 Pain Relevance 0.20

cytosol (GSK3A) carbohydrate metabolic process (GSK3A)

GSK3A (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 3 75.00 cytokine 1 25.00 agonist 33 5.00 Dopamine 9 5.00 dopamine receptor 6 5.00 Clonidine 6 5.00 Neurotransmitter 3 5.00 Hippocampus 3 5.00 Potency 3 5.00

Disease Link Frequency Relevance Heat Shock 6 97.04 Stress 3 91.04 Apoptosis 14 88.52 Colon Cancer 1 76.12 INFLAMMATION 3 75.00 Cancer 10 54.96 Bordatella Infection 15 5.00 Exencephaly / Neural Tube Defects 9 5.00 Wound Healing 6 5.00 Neurodegenerative Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alternately, Gi/o pathways can also alter the cytoskeleton through activation of Glycogen synthase kinase-3 (GSK-3) [42] or Rac, which promotes cell spreading [43,44].

Positive_regulation (activation) of GSK-3

1) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.19 Pain Relevance 0

Alternately, Gi/o pathways can also alter the cytoskeleton through activation of Glycogen synthase kinase-3 (GSK-3) [42] or Rac, which promotes cell spreading [43,44].

Positive_regulation (activation) of Glycogen synthase kinase-3

2) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.19 Pain Relevance 0

This effect of Ptx may reflect inhibition of basal Gi/o mediated effects on GSK-3 or Rac as described above.

Positive_regulation (mediated) of GSK-3

3) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0

Furthermore, the down-regulation of GSK-3 gene using small interference RNA resulted in a decline of the NAG-1 expression in the presence of LY294002.

Positive_regulation (using) of GSK-3 gene

4) Confidence 0.13 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.48 Pain Relevance 0.20

General Comments

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