INT121586

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.86
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSK3A) carbohydrate metabolic process (GSK3A)
GSK3A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 75.00 Quite High
cytokine 1 25.00 Low Low
agonist 33 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
dopamine receptor 6 5.00 Very Low Very Low Very Low
Clonidine 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 6 97.04 Very High Very High Very High
Stress 3 91.04 High High
Apoptosis 14 88.52 High High
Colon Cancer 1 76.12 Quite High
INFLAMMATION 3 75.00 Quite High
Cancer 10 54.96 Quite High
Bordatella Infection 15 5.00 Very Low Very Low Very Low
Exencephaly /

Neural Tube Defects

9 5.00 Very Low Very Low Very Low
Wound Healing 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternately, Gi/o pathways can also alter the cytoskeleton through activation of Glycogen synthase kinase-3 (GSK-3) [42] or Rac, which promotes cell spreading [43,44].
Positive_regulation (activation) of GSK-3
1) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.19 Pain Relevance 0
Alternately, Gi/o pathways can also alter the cytoskeleton through activation of Glycogen synthase kinase-3 (GSK-3) [42] or Rac, which promotes cell spreading [43,44].
Positive_regulation (activation) of Glycogen synthase kinase-3
2) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.19 Pain Relevance 0
This effect of Ptx may reflect inhibition of basal Gi/o mediated effects on GSK-3 or Rac as described above.
Positive_regulation (mediated) of GSK-3
3) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Furthermore, the down-regulation of GSK-3 gene using small interference RNA resulted in a decline of the NAG-1 expression in the presence of LY294002.
Positive_regulation (using) of GSK-3 gene
4) Confidence 0.13 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.48 Pain Relevance 0.20

General Comments

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