INT121589
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
However, pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) delayed and decreased the extent of AAP-induced apoptosis. | |||||||||||||||
| |||||||||||||||
|
However, pharmacological inhibition of glycogen synthase kinase-3 (GSK-3) delayed and decreased the extent of AAP-induced apoptosis. | |||||||||||||||
| |||||||||||||||
|
In comparison, endoplasmic reticulum stress-induced but not prooxidant-induced apoptosis of HuH7 cells was sensitive to GSK-3 inhibition. | |||||||||||||||
| |||||||||||||||
|
Furthermore, the down-regulation of GSK-3 gene using small interference RNA resulted in a decline of the NAG-1 expression in the presence of LY294002. | |||||||||||||||
| |||||||||||||||
|
Several small molecule inhibitors of GSK-3ß are available and demonstrate promising results both in vitro and in vivo as potential targeted therapies for the treatment of MTC. | |||||||||||||||
| |||||||||||||||
|
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo. | |||||||||||||||
| |||||||||||||||
|
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo. | |||||||||||||||
| |||||||||||||||
|
In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], dual-specificity, tyrosine phosphorylation regulated kinase 1A (DYRK1A) [3234], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases. | |||||||||||||||
| |||||||||||||||
|
In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], dual-specificity, tyrosine phosphorylation regulated kinase 1A (DYRK1A) [3234], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases. | |||||||||||||||
| |||||||||||||||
|
In addition, pigmented cells accumulated a large amount of glycogen in their cytoplasm which might be associated with inhibition of GSK3, which in case of melanoma has been linked to different modes of cell death. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.