INT12159

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Context Info
Confidence 0.72
First Reported 1985
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 46
Total Number 48
Disease Relevance 9.36
Pain Relevance 37.58

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extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
brain 8
spinal cord 4
frontal cortex 2
ventral 2
forebrain 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 396 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Somatostatin 9 100.00 Very High Very High Very High
Dopamine 9 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Bile 2 100.00 Very High Very High Very High
allodynia 9 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 8 100.00 Very High Very High Very High
Neuropathic Pain 26 99.82 Very High Very High Very High
Urological Neuroanatomy 14 99.52 Very High Very High Very High
Shock 6 99.48 Very High Very High Very High
Ganglion Cysts 2 98.80 Very High Very High Very High
Eating Disorder 3 98.48 Very High Very High Very High
Injury 3 98.42 Very High Very High Very High
Exocrine Pancreatic Insufficiency 1 97.16 Very High Very High Very High
Gallstones 7 96.50 Very High Very High Very High
Frailty 9 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholecystokinin (CCK) mRNA was detected by in situ hybridization at high magnification in some rat brain regions where CCK octapeptide (CCK-8) is thought to produce its pharmacological effects.
Transcription (detected) of CCK in brain associated with cholecystokinin
1) Confidence 0.72 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2812534 Disease Relevance 0.07 Pain Relevance 0.43
Distribution of CCK mRNA in particular regions (hippocampus, periaqueductal grey and thalamus) of the rat by in situ hybridization.
Transcription (Distribution) of CCK in hippocampus associated with thalamus, hippocampus and central grey
2) Confidence 0.72 Published 1989 Journal Neurosci. Lett. Section Title Doc Link 2812534 Disease Relevance 0.10 Pain Relevance 0.58
Cholecystokinin (CCK) mRNA was detected by in situ hybridization at high magnification in some rat brain regions where CCK octapeptide (CCK-8) is thought to produce its pharmacological effects.
Transcription (detected) of Cholecystokinin in brain associated with cholecystokinin
3) Confidence 0.72 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2812534 Disease Relevance 0.07 Pain Relevance 0.43
The expression of CCK-A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK-8 and camostate, whereas CCK-B receptor mRNA remained unaffected.
Transcription (mRNA) of CCK associated with cholecystokinin
4) Confidence 0.72 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.89 Pain Relevance 0.77
These data indicate that the previously reported modulatory action of opioids on central CCKergic systems could occur without affecting the preproCCK gene transcription and the tissue peptide concentrations.
Transcription (transcription) of CCK associated with opioid
5) Confidence 0.69 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0.09 Pain Relevance 1.07
The amount of mRNA expression of CCK-A and CCK-B receptors was determined by reverse transcription-polymerase chain reaction.
Transcription (expression) of CCK associated with cholecystokinin
6) Confidence 0.69 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12023057 Disease Relevance 0 Pain Relevance 0.69
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Transcription (levels) of cholecystokinin in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
7) Confidence 0.69 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.76
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Transcription (levels) of CCK mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
8) Confidence 0.69 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80
We examined the distribution of mRNA for the peptide cholecystokinin (CCK) with in situ hybridization in adult rat lumbar dorsal root ganglia following unilateral section of the sciatic nerve, as well as the effect of systemic CI 988, a selective antagonist of the CCK type B receptor, applied alone or in combination with intrathecal (i.t.) morphine, on the self-mutilating behavior of rats (autotomy) after axotomy, a sign of neuropathic pain and/or dysesthesia.
Spec (examined) Transcription (distribution) of peptide cholecystokinin in sciatic nerve associated with dysesthesia, antagonist, neuropathic pain, sciatic nerve, cholecystokinin, morphine and intrathecal
9) Confidence 0.69 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8515864 Disease Relevance 0.25 Pain Relevance 0.82
We examined the distribution of mRNA for the peptide cholecystokinin (CCK) with in situ hybridization in adult rat lumbar dorsal root ganglia following unilateral section of the sciatic nerve, as well as the effect of systemic CI 988, a selective antagonist of the CCK type B receptor, applied alone or in combination with intrathecal (i.t.) morphine, on the self-mutilating behavior of rats (autotomy) after axotomy, a sign of neuropathic pain and/or dysesthesia.
Spec (examined) Transcription (distribution) of CCK in sciatic nerve associated with dysesthesia, antagonist, neuropathic pain, sciatic nerve, cholecystokinin, morphine and intrathecal
10) Confidence 0.69 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8515864 Disease Relevance 0.25 Pain Relevance 0.82
Alternate brain sections were processed for CCK and preproenkephalin (PPE) mRNA in situ hybridization histochemistry.
Transcription (processed) of CCK in brain associated with cholecystokinin
11) Confidence 0.69 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.15 Pain Relevance 0.58
The difference in mRNA expressions of hypothalamic CCK and CCK-A and -B receptors between responder and non-responder rats to high frequency electroacupuncture analgesia.
Transcription (expressions) of CCK associated with electroacupuncture and analgesia
12) Confidence 0.68 Published 2006 Journal Peptides Section Title Doc Link 16472889 Disease Relevance 0 Pain Relevance 0.88
The mRNA expressions of CCK, and CCK-A and -B receptor were determined by real-time RT-PCR.
Transcription (expressions) of CCK associated with cholecystokinin
13) Confidence 0.68 Published 2006 Journal Peptides Section Abstract Doc Link 16472889 Disease Relevance 0 Pain Relevance 0.95
The difference in mRNA expressions of hypothalamic CCK and CCK-A and -B receptors between responder and non-responder rats to high frequency electroacupuncture analgesia.
Transcription (expressions) of CCK associated with electroacupuncture and analgesia
14) Confidence 0.68 Published 2006 Journal Peptides Section Title Doc Link 16472889 Disease Relevance 0 Pain Relevance 0.88
The mRNA expressions of CCK, and CCK-A and -B receptor were determined by real-time RT-PCR.
Transcription (expressions) of CCK associated with cholecystokinin
15) Confidence 0.68 Published 2006 Journal Peptides Section Abstract Doc Link 16472889 Disease Relevance 0 Pain Relevance 0.95
Isotopic in situ hybridization histochemistry revealed that within the limbic-hypothalamic nuclei, levels of CCK and preproenkephalin (PPE) mRNA levels were significantly higher in EB and EB + T4-treated animals compared with T4 or oil-treated animals.
Transcription (levels) of CCK associated with cholecystokinin
16) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9492057 Disease Relevance 0.08 Pain Relevance 0.36
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Transcription (levels) of CCK in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
17) Confidence 0.67 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.79
The effects of a single or repeated administrations of morphine on the tissue levels of cholecystokinin-like material (CCKLM) and pre pro cholecystokinin mRNA (CCK mRNA) were examined in various brain and spinal cord regions (cerebral cortex, cerebellum, hippocampus, septum, substantia nigra, lumbar enlargement) in adult rats using a specific radioimmunoassay and 'Northern blot' analysis, respectively.
Transcription (levels) of pro cholecystokinin mRNA in brain associated with substantia nigra, hippocampus, cerebral cortex, cholecystokinin, spinal cord and morphine
18) Confidence 0.60 Published 1992 Journal Neuropeptides Section Abstract Doc Link 1630603 Disease Relevance 0 Pain Relevance 0.80
Immunoreactive fibers to cholecystokinin-8, vasoactive intestinal polypeptide and glutamate decarboxylase (gamma-aminobutyrate-synthesizing enzyme, used as a marker of gamma-aminobutyrate) were widely distributed in the spinal cord, being particularly concentrated in the superficial dorsal horn, suggesting a close relationship to the pain transmission system.
Transcription (distributed) of cholecystokinin-8 in dorsal horn associated with pain, glutamate, dorsal horn, cholecystokinin and spinal cord
19) Confidence 0.59 Published 1985 Journal Neuroscience Section Abstract Doc Link 3887208 Disease Relevance 0.10 Pain Relevance 0.58
In situ hybridisation histochemistry revealed no difference in preproCCK mRNA levels within supraoptic neurones of (i.c.v.) morphine-treated compared with either i.c.v. vehicle-treated or untreated control animals.
Transcription (levels) of preproCCK associated with morphine
20) Confidence 0.53 Published 1998 Journal Brain Res. Section Abstract Doc Link 9507122 Disease Relevance 0 Pain Relevance 1.08

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