INT121599

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 9.28
Pain Relevance 8.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (RETNLB) extracellular region (RETNLB) molecular_function (RETNLB)
cellular_component (RETNLB)
Anatomy Link Frequency
joints 2
leukocytes 2
cortex 2
RETNLB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 100.00 Very High Very High Very High
cytokine 26 100.00 Very High Very High Very High
Inflammatory mediators 10 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
rheumatoid arthritis 5 100.00 Very High Very High Very High
Clonidine 6 99.98 Very High Very High Very High
Morphine 5 99.98 Very High Very High Very High
aspirin 4 99.68 Very High Very High Very High
cINOD 19 99.48 Very High Very High Very High
Pain 30 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 67 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 100.00 Very High Very High Very High
Adhesions 1 100.00 Very High Very High Very High
Peritonitis 1 99.78 Very High Very High Very High
Pain 28 98.98 Very High Very High Very High
Cv Unclassified Under Development 5 98.08 Very High Very High Very High
Cancer 3 97.68 Very High Very High Very High
Necrosis 3 97.44 Very High Very High Very High
Repression 1 96.44 Very High Very High Very High
Middle Cerebral Artery Infarction 1 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior PC significantly reduced the post-ischemic increased expression of many inflammatory genes including cytokines, chemokines, adhesion molecules and pro-inflammatory transcription factors, and prevented the infiltration of neutrophils and macrophages in the ipsilateral cortex of rats subjected to focal ischemia.
Negative_regulation (reduced) of Gene_expression (expression) of pro-inflammatory in cortex associated with chemokine, inflammation, ischemia, adhesions and cytokine
1) Confidence 0.21 Published 2006 Journal Neurochem. Int. Section Abstract Doc Link 16759752 Disease Relevance 1.26 Pain Relevance 0.74
It is still a common practice to prescribe non-steroidal anti-inflammatory drugs (NSAIDs) which primarily work by inhibiting the production of pro-inflammatory prostaglandins.
Negative_regulation (inhibiting) of Gene_expression (production) of pro-inflammatory associated with inflammation and cinod
2) Confidence 0.09 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2770552 Disease Relevance 1.31 Pain Relevance 0.98
Similarly, the relief of post-operative pain after abdominal surgery is also associated with a reduction in expression of pro-inflammatory mediators.
Negative_regulation (reduction) of Gene_expression (expression) of pro-inflammatory associated with pain and inflammatory mediators
3) Confidence 0.04 Published 2007 Journal J Pharm Pharm Sci Section Abstract Doc Link 18261375 Disease Relevance 2.11 Pain Relevance 2.04
High doses of acetylsalicylic acid were needed to inhibit pro-inflammatory cytokine production.
Negative_regulation (inhibit) of Gene_expression (production) of pro-inflammatory associated with aspirin, inflammation and cytokine
4) Confidence 0.03 Published 2004 Journal Scand. J. Immunol. Section Abstract Doc Link 15379866 Disease Relevance 0.76 Pain Relevance 0.80
The present in vitro study shows the ability of AMA, used at concentrations between 10(-7) to 10(-5) M, to reduce the production of the pro-inflammatory cytokines, specifically interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha).
Negative_regulation (reduce) of Gene_expression (production) of pro-inflammatory associated with necrosis, inflammation, cancer and cytokine
5) Confidence 0.03 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 20081246 Disease Relevance 1.01 Pain Relevance 0.84
Both in vitro and in vivo, during zymosan-induced peritonitis, morphine reduced gene expression of pro-inflammatory cytokines/chemokines and chemokine receptors.
Negative_regulation (reduced) of Gene_expression (expression) of pro-inflammatory associated with chemokine, inflammation, peritonitis, cytokine and morphine
6) Confidence 0.01 Published 2009 Journal Dev. Comp. Immunol. Section Abstract Doc Link 18760300 Disease Relevance 0.45 Pain Relevance 0.96
Additionally, clonidine reduced the capacity of leukocytes to express pro-inflammatory cytokines as assessed by treatment of cells ex vivo with lipopolysaccharide, whereas no repression of IL-10 production occurred.
Negative_regulation (reduced) of Gene_expression (express) of pro-inflammatory in leukocytes associated with inflammation, repression, cytokine and clonidine
7) Confidence 0.00 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192389 Disease Relevance 1.38 Pain Relevance 1.81
The objectives of this study were to determine whether LLLT decreased production of pro-inflammatory cytokines by cells from RA joints, and, if so, to identify cellular mechanisms.
Spec (whether) Negative_regulation (decreased) of Gene_expression (production) of pro-inflammatory in joints associated with inflammation, rheumatoid arthritis and cytokine
8) Confidence 0.00 Published 2009 Journal Lasers Surg Med Section Abstract Doc Link 19347944 Disease Relevance 1.00 Pain Relevance 0.63

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