INT12161

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 70
Total Number 75
Disease Relevance 34.22
Pain Relevance 34.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
neurons 8
nerve 4
sensory neurons 3
primary sensory neurons 3
spinal 2
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 133 100.00 Very High Very High Very High
nociceptor 49 100.00 Very High Very High Very High
agonist 269 99.98 Very High Very High Very High
Potency 114 99.96 Very High Very High Very High
Pain 353 99.92 Very High Very High Very High
Dorsal horn 112 99.92 Very High Very High Very High
adenocard 186 99.84 Very High Very High Very High
Analgesic 17 99.80 Very High Very High Very High
nMDA receptor 24 99.76 Very High Very High Very High
ischemia 70 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 197 100.00 Very High Very High Very High
Pain 444 99.92 Very High Very High Very High
Cv General 2 Under Development 33 99.92 Very High Very High Very High
Nociception 168 99.78 Very High Very High Very High
Coronary Artery Disease 4 99.74 Very High Very High Very High
Nervous System Injury 276 99.72 Very High Very High Very High
Neuropathic Pain 563 99.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

14 99.48 Very High Very High Very High
INFLAMMATION 307 99.42 Very High Very High Very High
Post Operative Pain 6 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, P2X receptor upregulation could account for neuronal hypersensitivity and contribute to abnormal pain responses associated with inflammatory injuries.
Positive_regulation (upregulation) of P2X in neuronal associated with pain, inflammation, injury and hypersensitivity
1) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11756492 Disease Relevance 1.07 Pain Relevance 0.70
The long-lasting allodynia was induced by activation of spinal P2X 2/3-receptors, and the induction and early phase of maintenance, but not the late phase, was mediated, at least in part, by the activation of spinal glial cells.
Positive_regulation (activation) of P2X 2 in spinal associated with allodynia
2) Confidence 0.67 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.44 Pain Relevance 0.53
We have been studying the role of ATP receptors in pain, and have already reported that activation of the P2X2/3 heteromeric channel/receptor in primary sensory neurons causes acutely tactile allodynia.
Positive_regulation (activation) of P2X2 in primary sensory neurons associated with brush evoked pain and pain
3) Confidence 0.67 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 0.94 Pain Relevance 0.78
In conclusion, P2-purinoceptor activation appears to depolarize locus coeruleus neurons by inhibiting a persistent potassium current, and at the same time opening calcium-sensitive sodium channels or calcium-sensitive non-selective cationic channels.
Positive_regulation (activation) of P2-purinoceptor in locus coeruleus associated with locus ceruleus and sodium channel
4) Confidence 0.60 Published 1992 Journal Neuroscience Section Abstract Doc Link 1630630 Disease Relevance 0 Pain Relevance 0.27
It was hypothesized that hypoxic chemotranduction with stabilization of HIF-1 and activation of P2X/P2Y purinoceptors stimulate the endogenous NO production in the rat carotid body.
Positive_regulation (activation) of P2X in carotid body associated with hypoxia
5) Confidence 0.55 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.48 Pain Relevance 0
Taken together with our previous finding that the alpha(beta)meATP-activated slow desensitizing current in DRG neurons is mediated by heteromeric P2X2/3 (P2X2 and P2X3) receptors, it is hypothesized that activation of heteromeric P2X2/3 receptors in peripheral terminals of capsaicin-insensitive primary afferent fibers leads to the induction of mechanical allodynia.
Spec (hypothesized) Positive_regulation (activation) of P2X2 in neurons associated with dorsal root ganglion, allodynia, qutenza and primary afferent fibers
6) Confidence 0.49 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10899177 Disease Relevance 0.69 Pain Relevance 1.07
These results provide evidence for alpha1-AR involvement in adrenergic augmentation of P2X3/P2X2/3 receptor-mediated responses on sensory nerve endings in the uninjured state in Sprague Dawley rats.
Positive_regulation (augmentation) of P2X2 in sensory nerve
7) Confidence 0.49 Published 2007 Journal J Pain Section Abstract Doc Link 17512257 Disease Relevance 0.35 Pain Relevance 0.85
Adenosine 5'-triphosphate (ATP) is implicated in peripheral pain signaling through activation of P2X receptors.
Positive_regulation (activation) of P2X associated with pain and adenocard
8) Confidence 0.42 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 0.66 Pain Relevance 0.40
Studies with various P2 receptor antagonists indicated that in this experimental model, activation of P2Y1 and P2X2 receptor subtypes might be particularly important for the detected effects.
Positive_regulation (activation) of P2X2 associated with antagonist
9) Confidence 0.41 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.45 Pain Relevance 0.14
As mentioned above, the highly specific functions of nucleotides are mediated by the activation of P2X and P2Y receptors on target cells.
Positive_regulation (activation) of P2X
10) Confidence 0.41 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.52 Pain Relevance 0.07
Extracellular nucleotides activate P2Y and P2X receptors either paracrinally (1) or autocrinally (2), leading to modulation of gene expression.
Positive_regulation (activate) of P2X
11) Confidence 0.41 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.34 Pain Relevance 0.32
The role of ATP in regard to extrinsic afferents in inflammatory tissues is primarily as a signalling molecule, directly activating sensory neurons via P2X and P2Y receptors.
Positive_regulation (activating) of P2X in sensory neurons associated with inflammation
12) Confidence 0.41 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0.62 Pain Relevance 0.26
After nerve injury, the mRNA of P2X(5) was increased, those of P2X(3) and P2X(6) were decreased, and those of P2X(2) and P2X(4) were unchanged.
Positive_regulation (increased) of P2X in nerve associated with nervous system injury
13) Confidence 0.37 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12527393 Disease Relevance 0.33 Pain Relevance 0.28
Note that phosphorylation of the P2X3 receptor or the EGFP-tagged P2X2 receptor is not detectable, whereas a positive control—the EGFP-tagged splicing factor SF3B1 (migration mass 97 kDa [23])—was detected by the antibody. b The same samples as in panel a were immunoblotted using peptide-specific P2X2 and P2X3 subunit polyclonal antibodies to verify the expression of the transfected genes

PMA-activated PKC does not drive the phosphorylation of P2X2 or P2X3 receptors

Positive_regulation (receptors) of P2X2 associated with kinase c
14) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0 Pain Relevance 0.12
-fibres (a total of 66%) were responsive to the P2Y receptor agonist, UTP and many of these were also responsive to the selective P2X agonist ?
Positive_regulation (selective) of P2X associated with agonist
15) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0 Pain Relevance 0.33
By example, the rat P2X2 receptor contains an inter-subunit zinc-binding site (rat P2X2 activity is enhanced by zinc), contributed to by the residues His120 and His231 (corresponding to Pro125 and His219 in zfP2X4.1) [31].
Positive_regulation (enhanced) of P2X2
16) Confidence 0.34 Published 2010 Journal Trends in Biochemical Sciences Section Body Doc Link PMC2824114 Disease Relevance 0 Pain Relevance 0.09
Despite these molecular differences, OtP2X was selectively activated by adenosine triphosphates in the micromolar range.
Positive_regulation (activated) of OtP2X associated with adenocard
17) Confidence 0.33 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0.09
In conclusion, extensive evidence demonstrates a postischemic time- and region-dependent upregulation of P2X2,4,7 and P2Y1 receptor subtypes in neurons and glial cells and suggests a direct role of P2 receptors in the pathophysiology of cerebral ischemia in vitro and in vivo.
Positive_regulation (upregulation) of P2X2 in neurons associated with cv general 4 under development and ischemia
18) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.78 Pain Relevance 0.37
ATP and UTP are the main purinergic agonists activating P2X or P2Y receptors.
Positive_regulation (activating) of P2X associated with agonist
19) Confidence 0.33 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.05 Pain Relevance 0.24
A peculiar phenotype is inherent to heteromeric P2X2/P2X3 (P2X2+3) receptors, which feature ??
Positive_regulation (inherent) of P2X2
20) Confidence 0.32 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.31 Pain Relevance 0.22

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