INT121650

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CXCR4) signal transducer activity (CXCR4) extracellular space (CXCL12)
signal transduction (CXCL12) extracellular region (CXCL12) cell adhesion (CXCL12)
CXCL12 (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 18.88 Low Low
chemokine 26 10.00 Low Low
antagonist 11 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 89.84 High High
Infection 1 89.52 High High
Colon Cancer 21 87.04 High High
Metastasis 44 76.72 Quite High
Cancer 121 75.48 Quite High
Breast Cancer 25 73.16 Quite High
INFLAMMATION 12 61.88 Quite High
Disease 7 55.88 Quite High
Malignant Neoplastic Disease 3 47.56 Quite Low
Carcinoma 7 45.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlabeled CXCL12 and the well-known CXCR4 inhibitors, AMD3100 and T22, blocked the binding of CXCL12(AF647) to SupT1 cells with 50% inhibitory concentrations of 92, 13, and 8 ng/ml, respectively.
Negative_regulation (blocked) of CXCL12 Binding (binding) of CXCR4
1) Confidence 0.47 Published 2004 Journal Cytometry A Section Body Doc Link 15382150 Disease Relevance 0.18 Pain Relevance 0
the ER, and CXCR4 protein which binds to CXCL12 is also retained in the ER,
Negative_regulation (retained) of CXCL12 Binding (binds) of CXCR4 protein
2) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.43 Pain Relevance 0

General Comments

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