INT121651

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 25
Disease Relevance 17.61
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CXCR4) signal transducer activity (CXCR4) extracellular space (CXCL12)
signal transduction (CXCL12) extracellular region (CXCL12) cell adhesion (CXCL12)
Anatomy Link Frequency
OC 316 2
OC 314 2
stromal cell 2
germ cell 2
OC 315 2
CXCL12 (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1609 100.00 Very High Very High Very High
Arthritis 58 99.20 Very High Very High Very High
rheumatoid arthritis 213 97.76 Very High Very High Very High
Central nervous system 52 97.48 Very High Very High Very High
cytokine 59 97.04 Very High Very High Very High
Inflammation 289 95.64 Very High Very High Very High
opiate 2 83.60 Quite High
Opioid 1 75.00 Quite High
antagonist 210 74.80 Quite High
metalloproteinase 15 73.84 Quite High
Disease Link Frequency Relevance Heat
Arthritis 60 99.20 Very High Very High Very High
Cancer 2636 98.96 Very High Very High Very High
Ovarian Cancer 1125 98.74 Very High Very High Very High
Reprotox - General 1 35 98.40 Very High Very High Very High
Rheumatoid Arthritis 213 97.76 Very High Very High Very High
Metastasis 451 97.64 Very High Very High Very High
Cervical Cancer 52 96.16 Very High Very High Very High
INFLAMMATION 335 95.64 Very High Very High Very High
Wound Healing 15 94.96 High High
Breast Cancer 255 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
the ER, and CXCR4 protein which binds to CXCL12 is also retained in the ER,
CXCL12 Binding (binds) of CXCR4 protein
1) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.42 Pain Relevance 0
Unlabeled CXCL12 and the well-known CXCR4 inhibitors, AMD3100 and T22, blocked the binding of CXCL12(AF647) to SupT1 cells with 50% inhibitory concentrations of 92, 13, and 8 ng/ml, respectively.
CXCL12 Binding (binding) of CXCR4
2) Confidence 0.41 Published 2004 Journal Cytometry A Section Body Doc Link 15382150 Disease Relevance 0.18 Pain Relevance 0
We have also used this method to evaluate CXCL12 binding and CXCR4 expression level in different subsets of human peripheral blood mononuclear cells.
CXCL12 Binding (binding) of CXCR4 in mononuclear cells
3) Confidence 0.41 Published 2004 Journal Cytometry A Section Body Doc Link 15382150 Disease Relevance 0.16 Pain Relevance 0
Until recently, CXCR4 was considered to be the only receptor for CXCL12, but
CXCL12 Binding (receptor) of CXCR4
4) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.17 Pain Relevance 0.07
Binding of CXCL12 to CXCR4 has been shown to
CXCL12 Binding (Binding) of CXCR4
5) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.09 Pain Relevance 0.04
CXCL12 binds principally to the receptor CXCR4, although
CXCL12 Binding (binds) of CXCR4
6) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.65 Pain Relevance 0.20
cells to bone [29] have shown that the interaction of CXCL12 with CXCR4 plays a
CXCL12 Binding (interaction) of CXCR4
7) Confidence 0.36 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.04 Pain Relevance 0
The interaction of CXCL12 with CXCR4 mainly affects chemotaxis, while the binding to CXCR7 mediates proliferation in tumor cells [35].
CXCL12 Binding (interaction) of CXCR4 associated with cancer
8) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.12 Pain Relevance 0.15
CXCL12 binding to CXCR4 induces cell movement, cytoskeleton reorganization, and gene activation, synergizing with hepatocyte growth factor.
CXCL12 Binding (binding) of CXCR4 in hepatocyte
9) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.36 Pain Relevance 0.06
The chemokine CXCL12 and its receptor, CXCR4, regulate neuronal migration, differentiation, and survival.
chemokine CXCL12 Binding (receptor) of CXCR4 in neuronal associated with chemokine
10) Confidence 0.30 Published 2010 Journal J. Neuroimmunol. Section Abstract Doc Link 20627326 Disease Relevance 0.17 Pain Relevance 0.30
These included CXCL13, CXCL12, CXCL8, CXCL1-3 and CXCL5, which are ligands for the chemokine receptors CXCR5, CXCR4 and CXCR2.
CXCL12 Binding (ligands) of CXCR4 associated with chemokine
11) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.25 Pain Relevance 0.95
Different studies demonstrated that in mouse germ cell migration and survival requires the CXCL12/CXCR4 interaction [106, 107].
CXCL12 Binding (interaction) of CXCR4 in germ cell
12) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.36 Pain Relevance 0.03
Although for many years the interaction between CXCR4 and CXCL12 was thought to be unique, more recently, it was reported that CXCL12 binds also to another receptor, named CXCR7 [34].
CXCL12 Binding (interaction) of CXCR4
13) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.28 Pain Relevance 0.18
In three other ovarian cancer cell lines (OC 314, OC 315, OC 316), it was demonstrated that CXCL12/CXCR4 interaction induces a dose-dependent cell proliferation through ERK1/2 and Akt activation that was dependent on EGFR phosphorylation caused by a mechanism involving the activity of the cytosolic tyrosine kinase c-Src [40].
CXCL12 Binding (interaction) of CXCR4 in OC 316 associated with ovarian cancer
14) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.52 Pain Relevance 0.09
In three other ovarian cancer cell lines (OC 314, OC 315, OC 316), it was demonstrated that CXCL12/CXCR4 interaction induces a dose-dependent cell proliferation through ERK1/2 and Akt activation that was dependent on EGFR phosphorylation caused by a mechanism involving the activity of the cytosolic tyrosine kinase c-Src [40].
CXCL12 Binding (interaction) of CXCR4 in OC 316 associated with ovarian cancer
15) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.52 Pain Relevance 0.09
In particular, this notion is further supported by the different mechanisms resulting from CXCR4 inhibition: (a) the reversal of stromal cell interactions responsible of tumor cell survival; (b) the blockade of proangiogenic activity of CXCL12 and the reduction of the dissemination and migration ability of tumor cells; (c) the blockade of tumor growth through autocrine/paracrine signaling mediated by CXCL12/CXCR4 interaction; (d) the mobilization of tumor cells from tissues to increase their sensitivity to conventional chemoterapeutic agents.
CXCL12 Binding (interaction) of CXCR4 in stromal cell associated with cancer
16) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.78 Pain Relevance 0.10
Different studies demonstrated that in mouse germ cell migration and survival requires the CXCL12/CXCR4 interaction [106, 107].
CXCL12 Binding (interaction) of CXCR4 in germ cell
17) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.36 Pain Relevance 0.03
In particular, this notion is further supported by the different mechanisms resulting from CXCR4 inhibition: (a) the reversal of stromal cell interactions responsible of tumor cell survival; (b) the blockade of proangiogenic activity of CXCL12 and the reduction of the dissemination and migration ability of tumor cells; (c) the blockade of tumor growth through autocrine/paracrine signaling mediated by CXCL12/CXCR4 interaction; (d) the mobilization of tumor cells from tissues to increase their sensitivity to conventional chemoterapeutic agents.
CXCL12 Binding (interaction) of CXCR4 in stromal cell associated with cancer
18) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.78 Pain Relevance 0.10
The major chemoattractant that drives EPCs is the SDF-1/CXCL12 chemokine and its receptor, CXCR4 [29].
SDF-1 Binding (receptor) of CXCR4 associated with chemokine
19) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.84 Pain Relevance 0.38
The major chemoattractant that drives EPCs is the SDF-1/CXCL12 chemokine and its receptor, CXCR4 [29].
CXCL12 Binding (receptor) of CXCR4 associated with chemokine
20) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.84 Pain Relevance 0.38

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