INT121663

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2002
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 76
Total Number 79
Disease Relevance 50.96
Pain Relevance 30.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CXCR3) plasma membrane (CXCR3) cytoplasm (CXCR3)
signal transducer activity (CXCR3)
Anatomy Link Frequency
B cells 16
T cells 15
fibroblasts 2
memory T cells 2
blood 2
CXCR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 3584 100.00 Very High Very High Very High
Arthritis 902 100.00 Very High Very High Very High
Cannabinoid receptor 9 100.00 Very High Very High Very High
cytokine 650 99.90 Very High Very High Very High
Inflammation 1316 99.86 Very High Very High Very High
rheumatoid arthritis 2410 99.80 Very High Very High Very High
antagonist 96 98.16 Very High Very High Very High
interstitial cystitis 2 97.96 Very High Very High Very High
cINOD 100 95.24 Very High Very High Very High
Osteoarthritis 484 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Juvenile Chronic Polyarthritis 380 100.00 Very High Very High Very High
INFLAMMATION 1404 99.86 Very High Very High Very High
Rheumatoid Arthritis 2425 99.80 Very High Very High Very High
Pulmonary Disease 398 99.28 Very High Very High Very High
Systemic Lupus Erythematosus 1152 99.20 Very High Very High Very High
Cancer 475 99.16 Very High Very High Very High
Atherosclerosis 306 98.80 Very High Very High Very High
Melanoma 10 98.58 Very High Very High Very High
Hypersensitivity 28 98.52 Very High Very High Very High
Hepatocellular Cancer 5 98.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this chapter, we describe the collection, isolation and activation of human peripheral blood-derived T lymphocytes and methods to examine the expression of CXCR3 and its atypical variants at both mRNA and protein levels, as well as protocols for exploring the biochemical and functional responses of T lymphocytes to all known CXCR3 agonists.
Spec (examine) Gene_expression (expression) of CXCR3 in T lymphocytes associated with agonist
1) Confidence 0.77 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20379873 Disease Relevance 0.40 Pain Relevance 0.50
Analysis of CXCR3 and atypical variant expression and signalling in human T lymphocytes.
Gene_expression (expression) of CXCR3 in T lymphocytes
2) Confidence 0.77 Published 2010 Journal Methods Mol. Biol. Section Title Doc Link 20379873 Disease Relevance 0.40 Pain Relevance 0.52
Because CXCR3 expression may be influenced by the level of CXCL10, sera from healthy controls and from the different patient groups were tested for the presence of this chemokine.
Gene_expression (expression) of CXCR3 associated with chemokine
3) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.58 Pain Relevance 0.28
In comparison with healthy individuals, in patients with RA a significant fraction of B cells showed a decreased expression of CXCR5 and CCR6 and increased levels of CXCR3.
Gene_expression (expression) of CXCR3 in B cells associated with rheumatoid arthritis
4) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.05 Pain Relevance 0.60
We found that in healthy individuals most B cells are positive for CXCR3; however, the mean fluorescence intensity was rather low and only a few B cells expressed CXCR3, at a level comparable to that seen after staining with mAb specific for CXCR5 (Figs 1 and 7).
Gene_expression (expressed) of CXCR3 in B cells
5) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.82 Pain Relevance 0.41
Our results show that practically all B cells express CXCR3, although with a low mean fluorescence intensity.
Gene_expression (express) of CXCR3 in B cells
6) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.22 Pain Relevance 0.19
Using a transmigration assay we were able to show that low levels of CXCR3 expression are sufficient to permit a response to the migrational stimulus of the chemokine CXCL10.
Gene_expression (expression) of CXCR3 associated with chemokine
7) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.48 Pain Relevance 0.34
Similarly, it was shown for T lymphocytes that after activation with interleukin-2 the expression of CXCR3 is upregulated [32].
Gene_expression (expression) of CXCR3 in T lymphocytes
8) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.38 Pain Relevance 0.28
In line with this interpretation we observed CXCR3 expression on synovial tissue B cells.
Gene_expression (expression) of CXCR3 in B cells
9) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.29 Pain Relevance 0.23
The level of CXCL10 may influence CXCR3 expression
Gene_expression (expression) of CXCR3
10) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.44 Pain Relevance 0.33
Activation of human B cells using a culture system in vitro showed that after stimulation with cytokines the expression of CXCR3 is upregulated [31].
Gene_expression (expression) of CXCR3 in B cells associated with cytokine
11) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.45 Pain Relevance 0.28
There was therefore no evidence that CXCR3 expression is preferentially enhanced on CD5+ B cells.


Gene_expression (expression) of CXCR3 in B cells
12) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.45 Pain Relevance 0.31
After differentiation, the level of CXCR3 expression seems to be upregulated because the frequency of CXCR3hi B cells increases from naive to memory B cells.
Gene_expression (expression) of CXCR3 in memory B cells
13) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.27 Pain Relevance 0.21
Furthermore, we addressed the question of whether there is a significant correlation between the expression of CXCR5 with that of CXCR4, CCR6 and CXCR3.
Gene_expression (expression) of CXCR3
14) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.85 Pain Relevance 0.34
In contrast, in patients with RA a significant fraction of naive B cells showed high expression of CXCR3.
Gene_expression (expression) of CXCR3 in naive B cells associated with rheumatoid arthritis
15) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.87 Pain Relevance 0.38
To address the question of B cell migration into the inflamed synovial tissue of patients with rheumatoid arthritis (RA), peripheral blood naive B cells, memory B cells and plasma cells were analyzed for cell surface expression of the chemokine receptors CXCR3, CXCR4, CXCR5, CCR5, CCR6, CCR7 and CCR9.
Spec (analyzed) Gene_expression (expression) of CXCR3 in B cell associated with chemokine and rheumatoid arthritis
16) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 0.88 Pain Relevance 0.42
The analysis of CXCR3 expression on B cells revealed that in comparison with healthy individuals, untreated patients with RA had an increase in the frequency of CXCR3hi B cells.
Gene_expression (expression) of CXCR3 in B cells associated with rheumatoid arthritis
17) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.78 Pain Relevance 0.76
Furthermore, flagellin, loxoribine and unmethylated CpG oligonucleotide (TLR5, TLR7 and TLR9 ligands, respectively) did not enhance IFN-gamma-dependent CXCR3 ligand production in HMVEC.
Gene_expression (production) of CXCR3
18) Confidence 0.63 Published 2006 Journal Lab. Invest. Section Abstract Doc Link 16847431 Disease Relevance 0.34 Pain Relevance 0.31
The chemokine receptor CXCR3 is expressed mainly on activated T lymphocytes and binds three pro-inflammatory, interferon-gamma-inducible chemokines: monokine induced by IFN-gamma (Mig/CXCL9), IFN-gamma-induced protein-10 (IP-10/CXCL10) and IFN-gamma-inducible T-cell alpha-chemoattractant (I-TAC/CXCL11).
Gene_expression (expressed) of CXCR3 in T-cell associated with chemokine and inflammation
19) Confidence 0.60 Published 2010 Journal Methods Mol. Biol. Section Abstract Doc Link 20379873 Disease Relevance 0.39 Pain Relevance 0.48
Human T-lymphoid (CXCR4(+)) SupT1 cells and CXCR4-transfected, but not CCR5- or CXCR3-transfected, human astroglioma U87.CD4 cells specifically bound CXCL12(AF647) in a concentration-dependent manner.
Gene_expression (transfected) of CXCR3
20) Confidence 0.58 Published 2004 Journal Cytometry A Section Body Doc Link 15382150 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox